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Synthesis and Antimicrobial Activity of 5-Aryl-4-Acyl-3-Hydroxy-1-[2-(2-Hydroxyethoxy)-Ethyl]-3-Pyrrolin-2-Ones

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Pharmaceutical Chemistry Journal Aims and scope

Interaction of 2-(2-aminoethoxy)ethanol with a mixture of an aromatic aldehyde and the methyl esters of acetylpyruvic acids yielded 5-aryl-4-acyl-3-hydroxy-1-[2-(2-hydroxyethoxy)ethyl]-3-pyrrolin-2-ones. The antimicrobial activity of the compounds synthesized here was studied.

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References

  1. V. L. Gein, V. N. Vychegzhanina, E. B. Levandovskaya, et al., Khim.-Farm. Zh., 44(7), 30 – 33 (2010); Pharm. Chem. J., 44(7), 370 – 373 (2010).

  2. V. L. Gein, Tetrahydropyrrol- and Tetrahydrofuran-2,3-diones [in Russian], PGFA, Perm (2004).

  3. M. D. Mashkovskii, Medicines: A Handbook for Doctors [in Russian], Novaya Volna, Moscow (2005).

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Russian Ministry of Health, Perm, Russia

    V. L. Gein, T. F. Odegova, S. N. Rogachev & A. A. Bobyleva

  2. Academician E. A. Vagner Perm State Medical Academy, Russian Ministry of Health, Perm, Russia

    L. F. Gein

Authors
  1. V. L. Gein
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  2. T. F. Odegova
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  3. S. N. Rogachev
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  4. A. A. Bobyleva
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  5. L. F. Gein
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Corresponding author

Correspondence to V. L. Gein.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 3, pp. 32 – 34, March, 2015.

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Gein, V.L., Odegova, T.F., Rogachev, S.N. et al. Synthesis and Antimicrobial Activity of 5-Aryl-4-Acyl-3-Hydroxy-1-[2-(2-Hydroxyethoxy)-Ethyl]-3-Pyrrolin-2-Ones. Pharm Chem J 49, 175–177 (2015). https://doi.org/10.1007/s11094-015-1248-2

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  • DOI: https://doi.org/10.1007/s11094-015-1248-2

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