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Treatment outcomes of single-fraction stereotactic radiosurgery for adenoid cystic carcinoma: a case series of 55 patients

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Abstract

Purpose

This study aimed to analyze the treatment outcomes of single-fraction stereotactic radiosurgery (SRS) for adenoid cystic carcinoma patients.

Methods

Retrospective analysis was conducted for 55 patients with 66 lesions. SRS intentions were categorized as definitive, adjuvant, salvage, and palliative. Tumor control was defined as local (within 50% isodose line), marginal (outside 50% isodose line), and distant (metastasis outside head/neck).

Results

The median age was 60 years (range 21–85), with 53% males. Tumor origin was head/neck for 88% and trachea/lung for 12%. 61% were recurrent lesions. Median interval from diagnosis to SRS was 14 months. Preceding surgery was performed in 30%. SRS was administered as definitive (30 lesions), adjuvant (13), salvage (19), and palliative (4). SRS was used as a boost to external beam radiation therapy (EBRT) in 39%. Concurrent chemotherapy was administered in 26%. 5-, 10-, and 15-year local control rates were 60%, 33%, and 27%, respectively; local/marginal control rates were 29%, 13%, and 10%. For recurrent lesions treated with SRS without EBRT, 5-year local control rate was 14%, and local/marginal control rate was 5%. For recurrent lesions treated with SRS and EBRT, 5-year local control rate was 100%, and local/marginal control rate was 40%. The rate of distant failure after SRS was 40%. Older age and distant metastasis before SRS were negative factors for overall survival.

Conclusion

SRS provided a high rate of local tumor control, but marginal failure was frequent. Integrating SRS with added EBRT exhibits potential for enhancing local and local/marginal tumor control, particularly in recurrent cases.

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Data availability

No datasets were generated or analysed during the current study.

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Acknowledgements

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Neurological Surgery, Mayo Clinic, 200 First Street Southwest, 55905, Rochester, Minnesota, USA

    Sukwoo Hong, Yuki Shinya, Ian F. Parney, Michael J. Link & Bruce E. Pollock

  2. Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA

    Yolanda I. Garces

  3. Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA

    Katharine A. Price

Authors
  1. Sukwoo Hong
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  2. Yolanda I. Garces
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  3. Katharine A. Price
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  4. Yuki Shinya
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  6. Michael J. Link
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  7. Bruce E. Pollock
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by SH. The first draft of the manuscript was written by SH and all authors commented and critically revised the previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Bruce E. Pollock.

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Ethics approval and consent to participate

This study was performed in line with the principles of the Declaration of Helsinki. Approval from the institutional review board was obtained (ID: 15-001684). Informed consent was waived per institutional review board criteria.

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The authors declare no competing interests.

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Hong, S., Garces, Y.I., Price, K.A. et al. Treatment outcomes of single-fraction stereotactic radiosurgery for adenoid cystic carcinoma: a case series of 55 patients. J Neurooncol 166, 369–376 (2024). https://doi.org/10.1007/s11060-024-04561-1

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  • DOI: https://doi.org/10.1007/s11060-024-04561-1

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