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A multi-institutional analysis of clinical outcomes and patterns of care of 1p/19q codeleted oligodendrogliomas treated with adjuvant or salvage radiation therapy

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Abstract

Purpose

Practice patterns vary for adjuvant treatment of 1p/19q-codeleted oligodendroglioma patients. This study evaluates the outcomes of adjuvant (aRT) versus salvage radiation therapy (sRT) in a multi-institutional cohort.

Methods

Oligodendroglioma patients with confirmed 1p/19q codeletion who were treated with RT with or without chemotherapy from 2000 to 2017 at four tertiary centers were retrospectively reviewed. Overall survival (OS), post-RT progression-free survival (PFS), freedom-from-RT (FFRT), and radiation necrosis (RN) rates were determined using Kaplan–Meier analyses. OS1/PFS1 were defined from the initial surgery. OS2/PFS2 were defined from the RT start-date. Multivariable analyses (MVAs) of prognostic factors for OS and PFS were performed with Cox regression.

Results

One hundred eighty-six patients were identified: 124(67%) received aRT and 62(33%) received sRT; of sRT patients, 58% were observed after surgery while 42% received chemotherapy without aRT. The median time from initial diagnosis to sRT was 61 months, and 74% had reoperations before sRT. sRT had longer OS1 than aRT (94% vs. 69% at 10 years, p = 0.03) and PFS1 (10-year PFS of 80% vs. 68%, p = 0.03), though sRT was not associated with significantly different OS1/PFS1 on MVAs. Chemotherapy did not delay sRT compared to observation and had worse PFS2 (42% vs. 79% at 5 years, p = 0.08). Higher RT dose was not associated with improved clinical outcomes but was associated with higher symptomatic RN rate (15% vs. 0% at 2 years, p = 0.003).

Conclusions

Delaying RT for selected oligodendroglioma patients appears safe. Adjuvant chemotherapy does not delay sRT longer than observation and may be associated with worse PFS after RT.

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Funding

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Authors and Affiliations

  1. Department of Radiation Oncology, Center for Advanced Medicine, Washington University School of Medicine, 4921 Parkview Place, Campus Box #8224, St. Louis, MO, 63110, USA

    Alexander J. Lin, Shahed N. Badiyan & Jiayi Huang

  2. Department of Radiation Oncology, Northwestern University, Chicago, IL, USA

    Liam T. Kane & Tim J. Kruser

  3. Department of Radiation Oncology, University of Maryland, Baltimore, MD, USA

    Jason K. Molitoris

  4. Department of Radiation Oncology, Columbia University, New York, NY, USA

    Deborah R. Smith & Tony J. C. Wang

  5. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

    Sonika Dahiya

Authors
  1. Alexander J. Lin
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  2. Liam T. Kane
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  4. Deborah R. Smith
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  6. Shahed N. Badiyan
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  7. Tony J. C. Wang
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  8. Tim J. Kruser
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  9. Jiayi Huang
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Contributions

All authors contributed to the experimental design, analysis, and interpretation of the data. All authors were involved in the writing of the manuscript at draft and revision stages, and have read and approved the final version.

Corresponding author

Correspondence to Jiayi Huang.

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Conflict of interest

S.B. had speaker's honoraria from Varian Medical Systems for topics outside this work. T.W. reports personal fees and non-financial support from AbbVie, non-financial support from Merck, personal fees from AstraZeneca, personal fees from Doximity, non-financial support from Novocure, personal fees and non-financial support from Elekta and personal fees from Wolters Kluwer, outside the submitted work. T.K. reports personal fees from AbbVie, AstraZeneca, and Varian Medical Systems, all outside the submitted work. J.H. reports research support from Pfizer and Cantex, personal fees from Viewray, outside the submitted work.

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Lin, A.J., Kane, L.T., Molitoris, J.K. et al. A multi-institutional analysis of clinical outcomes and patterns of care of 1p/19q codeleted oligodendrogliomas treated with adjuvant or salvage radiation therapy. J Neurooncol 146, 121–130 (2020). https://doi.org/10.1007/s11060-019-03344-3

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  • DOI: https://doi.org/10.1007/s11060-019-03344-3

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