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The predictive potential of hyponatremia for glioblastoma patient survival

  • Clinical Study
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Abstract

Glioblastoma is a devastating malignancy with a dismal survival rate. Currently, there are limited prognostic markers of glioblastoma including IDH1, ATRX, MGMT, PTEN, EGFRvIII, and others. Although these biomarkers for tumor prognosis are available, a surgical biopsy must be performed for these analyses, which has morbidity involved. A non-invasive and readily available biomarker is sought after which provides clinicians prognostic information. Sodium is an electrolyte that is easily and quickly obtained through analysis of a patient’s serum. Hyponatremia has been shown to have a predictive and negative prognostic indication in multiple cancer types, but the role of glioblastoma patients’ serum sodium at the time of diagnosis in predicting glioblastoma patient survival has not been determined. We assessed whether hyponatremia at the time of glioblastoma diagnosis correlates to patient survival and show that in our cohort of 200 glioblastoma patients, sodium, at any level, did not significantly correlate to glioblastoma survival, unlike what is seen in multiple other cancer types. We further demonstrate that inducing hyponatremia in an orthotopic murine model of glioblastoma has no effects on tumor progression and survival.

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Authors and Affiliations

  1. Department of Neurosurgery, Penn State Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA

    Oliver D. Mrowczynski, Alexandre J. Bourcier, Sara T. Langan & Elias B. Rizk

  2. Department of Public Health Sciences, Penn State Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA

    Jason Liao

  3. Department of Pathology, Penn State Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA, 17033, USA

    Charles S. Specht

Authors
  1. Oliver D. Mrowczynski
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  2. Alexandre J. Bourcier
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  3. Jason Liao
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  4. Sara T. Langan
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Corresponding author

Correspondence to Oliver D. Mrowczynski.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Data availability statement The datasets generated during and/or analysed during the current study are not publicly available due to the security of our patient data but are available from the corresponding author on reasonable request. All datasets are kept in REDCap (Research Electronic Data Capture), a secure web application for building and managing online surveys and databases. REDcap is HIPAA compliant, all data is stored on a secure server, and encrypted, access to the database requires user authentication with password, and data access is based on individual’s role in the project.

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Mrowczynski, O.D., Bourcier, A.J., Liao, J. et al. The predictive potential of hyponatremia for glioblastoma patient survival. J Neurooncol 138, 99–104 (2018). https://doi.org/10.1007/s11060-018-2774-z

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  • DOI: https://doi.org/10.1007/s11060-018-2774-z

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