Abstract
The psychopathological structure and prognostic significance of mild cognitive impairment syndrome (MCI) were studied in a two-year prospective study of randomized cohorts of elderly subjects whose mental state corresponded to the criteria for MCI. A total of 40 patients aged from 50 to 80 years were studied. Patients underwent clinical history-taking, neuropsychological, psychometric, and genetic investigations (genotyping for ApoE), as well as brain imaging studies. The psychopathological structure and psychometric characteristics of MCI syndrome are presented. Clinical and genetic factors with prognostic significance are identified.
Similar content being viewed by others
References
S. I. Gavrilova, The Pharmacotherapy of Alzheimer’s Disease [in Russian], Pul’s, Moscow (2003).
Ya. B. Kalyn, Clinical Features of the Initial Manifestations and Subsequent Course of Senile Dementia [in Russian], Author’s Abstract of Doctoral Thesis in Medical Sciences, Moscow (1990).
G. I. Korovaitseva, T. V. Shcherbatykh, N. D. Selezneva, et al., “Genetic association between alleles of the apolipoprotein E (ApoE) gene and different types of Alzheimer’s disease,” Genetika, 37, No. 4, 529–535 (2001).
A. Kurts, “Mild cognitive dysfunction syndrome,” in: Proceedings of the Second Russian Conference “Alzheimer’s Disease and Aging: from Neurobiology to Therapy [in Russian], Moscow (1999).
A. R. Luriya, Basic Neuropsychology [in Russian], Moscow State University, Moscow (1973).
A. R. Luriya, Higher Cortical Functions in Humans and their Impairments in Local Brain Damage [in Russian], Moscow State University, Moscow, Vol. 1 (1969); Akadem Proekt, Moscow, Vol. 2 (2000).
I. F. Roshchina and G. A. Zharikov, “A neuropsychological approach to the diagnosis of mild dementia in the elderly and aged,” Zh. Nevrol. Psikhiat., 2, 34–40 (1998).
Handbook of Psychiatry [in Russian], A. S. Tiganov (ed.), Meditsina, Moscow (1999), Vol. 1, pp. 246–247.
N. D. Selezneva, Comparative Age-Related Characteristics of the Clinical Features and Course of Alzheimer’s Disease [in Russian], Author’s Abstract of Doctoral Thesis in Medical Sciences, Moscow (1990).
B. Dubois, A. Slachevsky, I. Litvan, and B. Pillon, “A frontal assessment battery at bedside,” Neurology, 55, 1621–1626 (2000).
B. Dubois and M. L. Albert, “Amnestic MCI or prodromal Alzheimer’s disease,” Lancet Neurology, 3, 246–248 (2004).
M. F. Folstein, S. E. Folstein, and P. R. McHugh, “Mini-Mental State. A practical method for grading the cognitive state of patients for the clinician,” J. Psychiat. Res., 2, 189–198 (1975).
J. Golomb, A. Kluger, P. Garrad, and S. Ferris, Clinician’s Manual on Mild Cognitive Impairment, Science Press Ltd., London (2001).
E. H. Kaplan, H. Goodglass, and S. Weintraub, The Boston Naming Test, Philadelphia (1983).
J. C. Morris, “The clinical dementia rating (CDR). Current version and scoring rules,” Neurology, 43, 2412–2414 (1993).
R. C. Petersen, J. C. Stevens, M. Ganguli, et al., “Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review), Report of the Quality Standards Subcommittee of the American Academy of Neurology,” Neurology, 56, No. 9, 1133–1142 (2001).
R. C. Petersen, “Aging, mild cognitive impairment, and Alzheimer’s disease,” Neurol. Clin., 18, No. 4, 789–806 (2000).
R. C. Petersen, D. S. Knopman, B. F. Boeve, et al., Mild Cognitive Impairment. Alzheimer’s Disease and Related Disorders: Research Advances, Ana Aslas International Academy of Aging, Bucharest (2002), p. 111.
R. C. Peterson, G. E. Smith, S. C. Waring, et al., “Mild cognitive impairment: Clinical characterization and outcome,” Arch. Neurol., 56, 303–308 (1999).
R. C. Petersen, J. C. Stevens, M. Ganguli, et al., “Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology,” Neurology, 56, No. 9, 1133–1142 (2001).
R. C. Petersen, “Mild cognitive impairment as a diagnostic entity,” J. Intern. Med., 256, 183–194.
R. C. Petersen and J. Touchon, “Consensus on mild cognitive impairment. Research and Practice in Alzheimer’s Disease,” in: Proceedings of Joint Meeting, Serdi Publ., Paris (2005), No. 10, pp. 24–32.
B. Reisberg, S. H. Ferris, M. J. der Leon, et al., “The global deterioration scale (CDS). An instrument for the assessment of primary degenerative dementia,” Amer. J. Psychiat., 139, 1136–1139 (1982).
K. I. Shulman, R. Shedletsky, and I. Silver, “The challenge of time: clock drawing and cognitive function in the elderly,” Int. J. Geriat. Psychiat., 1, 135–140 (1986).
D. Wechsler, Wechsler Memory Scale Manual, Psychological Corporation, San Antonio (1974).
J. A. Yesavage, T. L. Brink, T. L. Rose, et al., “Development and validation of a geriatric depression screening scale: A preliminary report,” J. Psychiat. Res., 17, 37–49 (1983).
Author information
Authors and Affiliations
Additional information
__________
Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 107, No. 1, pp. 4–10, January, 2007.
Rights and permissions
About this article
Cite this article
Gavrilova, S.I., Fedorova, Y.B., Roshchina, I.F. et al. Prognosis of mild cognitive impairment syndrome: Data from a two-year clinical follow-up study. Neurosci Behav Physi 38, 129–134 (2008). https://doi.org/10.1007/s11055-008-0018-y
Issue Date:
DOI: https://doi.org/10.1007/s11055-008-0018-y