Abstract
A convenient and efficient synthesis of multi-substituted dihydropyrano[2,3-c]pyrazole derivatives is reported. The four-component reaction of 4-hydrazinobenzoic acid, \(\beta \)-keto esters, aromatic aldehydes, and malononitrile using 10 mol% CAN catalyst in water under ultrasound irradiation produced the target compounds in good-to-excellent yields. This method has advantages over conventional methods in being economic, non-toxic, and environmentally compatible due to its use of efficient and eco-friendly CAN catalyst and water solvent.
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Acknowledgments
This work was supported by the Natural Science Foundation of China (No. 21162028) and the Natural Science Foundation of the Xinjiang Science Technology Agency (No. 2009 211A02).
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Ablajan, K., Liju, W., Kelimu, Y. et al. Cerium ammonium nitrate (CAN)-catalyzed four-component one-pot synthesis of multi-substituted pyrano[2,3-\(\varvec{c}\)]pyrazoles under ultrasound irradiation. Mol Divers 17, 693–700 (2013). https://doi.org/10.1007/s11030-013-9465-7
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DOI: https://doi.org/10.1007/s11030-013-9465-7