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Phosphoinositides in Ca2+ signaling and excitation–contraction coupling in skeletal muscle: an old player and newcomers

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Abstract

Since the postulate, 30 years ago, that phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P 2) as the precursor of inositol 1,4,5-trisphosphate (Ins(1,4,5)P 3) would be critical for skeletal muscle excitation–contraction (EC) coupling, the issue of whether phosphoinositides (PtdInsPs) may have something to do with Ca2+ signaling in muscle raised limited interest, if any. In recent years however, the PtdInsP world has expanded considerably with new functions for PtdIns(4,5)P 2 but also with functions for the other members of the PtdInsP family. In this context, the discovery that genetic deficiency in a PtdInsP phosphatase has dramatic consequences on Ca2+ homeostasis in skeletal muscle came unanticipated and opened up new perspectives in regards to how PtdInsPs modulate muscle Ca2+ signaling under normal and disease conditions. This review intends to make an update of the established, the questioned, and the unknown regarding the role of PtdInsPs in skeletal muscle Ca2+ homeostasis and EC coupling, with very specific emphasis given to Ca2+ signals in differentiated skeletal muscle fibers.

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Acknowledgments

This work was supported by grants from Centre National de la Recherche Scientifique (CNRS) and Université Lyon 1 to Centre de Génétique et de Physiologie Moléculaire et Cellulaire, by a grant from Association Française contre les Myopathies to V.J. (AFM # 18648), by the Hungarian National Science Fund (NN-107765) to L.C. and by the European Union, co-financed by the European Social Fund (TÁMOP-4.1.2.E-13/1/KONV-2013-0010).

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  1. Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary

    Laszlo Csernoch

  2. UMR CNRS 5534, Centre de Génétique et de Physiologie Moléculaire et Cellulaire, Université Lyon 1, Bât. Raphaël Dubois, 43 boulevard du 11 novembre 1918, 69622, Villeurbanne, France

    Vincent Jacquemond

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Csernoch, L., Jacquemond, V. Phosphoinositides in Ca2+ signaling and excitation–contraction coupling in skeletal muscle: an old player and newcomers. J Muscle Res Cell Motil 36, 491–499 (2015). https://doi.org/10.1007/s10974-015-9422-4

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  • DOI: https://doi.org/10.1007/s10974-015-9422-4

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