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Roles of Junglas nigra husk extract microelements as radioprotectors: an in vivo model using 99mTc-radiopharmaceuticals

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Abstract

The aim of this work was to analyze the multi-elemental composition of the extracts of J. nigra husk, with an assessment of the possible influence of their microelements on biochemical, toxicological and radioprotective effects of in rats exposed to radiation from 99mTc-radiopharmaceuticals. The elements in extract were quantified: microelements (Zn>Al>Se>Cu>Sr>Cr>Ni>Mn>Ba>I>V) and toxic-elements (Pb>Hg>Cd>As). The use of extract in rats showed no clinical evidence of toxicity in terms of biochemical parameters. The results showed significant alteration in the organs accumulation of 99mTc-radiopharmaceuticals. The results showed that extract of J. nigra husk may act as a potential radioprotector of organ system.

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Data availability

The authors declare that the data supporting the findings of this study are available within the paper. Should any raw data files be needed in another format they are available from the corresponding author upon reasonable request. Source data are provided with this paper.

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Acknowledgements

This study was supported by the Ministry of Education, Science and Technology Development of the Republic of Serbia (Grant Nos. 451-03-66/2024-03/200017). We thank Zoran Paunovic and Miomir-Misa Rajkovic for kindly providing us fruit and leaves sample.

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Authors and Affiliations

  1. The Academy of Applied Preschool Teaching and Health Studies, Kosančićeva 36, 37000, Kruševac, Serbia

    Katarina M. Rajković

  2. “VINČA” Institute of Nuclear Sciences—National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia

    Mirjana Đurašević, Zorana Milanović, Sanja Vranješ-Đurić, Drina Janković, Marija Mirković & Zorica Obradović

  3. Department of Radiotherapy Physics, Institute for Oncology and Radiology of Serbia (IORS), Pasterova 14, 11000, Belgrade, Serbia

    Milan Markićević

  4. Faculty of Chemistry, University of Belgrade, Belgrade, Serbia

    Jelena Mutić

Authors
  1. Katarina M. Rajković
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  2. Mirjana Đurašević
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Correspondence to Katarina M. Rajković.

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Rajković, K.M., Đurašević, M., Markićević, M. et al. Roles of Junglas nigra husk extract microelements as radioprotectors: an in vivo model using 99mTc-radiopharmaceuticals. J Radioanal Nucl Chem 333, 2297–2305 (2024). https://doi.org/10.1007/s10967-024-09464-z

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