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Redirecting Normal and Cancer Stem Cells to a Mammary Epithelial Cell Fate

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

Tissue microenvironments, also known as stem cell niches, influence not only resident cells but also cells in surrounding tissues. Physical and biochemical intercellular signals originating from resident stem cells or non-stem cells participate in the homeostasis of the tissue regulating cell proliferation, differentiation, wound healing, tissue remodeling, and tumorigenesis. In recent publications it has been demonstrated that the normal mouse mammary microenvironment can provide development and differentiation guidance to not only resident mammary cells but also cells of non-mammary origin including tumor-derived cells. When placed in reforming mammary stem cell niches the non-mammary cells proliferate and differentiate along mammary epithelial cell lineages and contribute progeny to reforming mammary gland outgrowths. The tumor-derived cells that are redirected to assume mammary epithelial phenotypes lose their cancer-forming capacity and shift their gene expression profiles from a cancer profile towards a normal mammary epithelial expression profile. This review summarizes the recent discoveries regarding the ability of the normal mouse mammary microenvironment to dictate the cell fates of non-mammary cells introduced into mammary stem cell niches.

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Abbreviations

BMSC:

Bone marrow-derived stem cell

CMDS:

Classic multidimensional scaling

CNS:

Central nervous system

ECM:

Extracellular matrix

EMT:

Epithelial-mesenchymal transition

ER:

Estrogen receptor

ESC:

Embryonic stem cell

HER:

Human epidermal growth factor receptor

K:

keratin

LTR:

Long terminal repeat

MEC:

mammary epithelial cell

MMP:

Matrix metalloproteinase

MMTV:

Mouse mammary tumor virus

NSC:

Neural stem cell

NT2:

NTERA-2 cl

TEB:

Terminal endbud

TDLU:

Terminal ductal lobular unit

TGF:

Transforming growth factor

TNBC:

Triple negative breast cancer

TSC:

Testicular-derived stem cell

WAP:

Whey acidic protein promoter

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Authors and Affiliations

  1. Department of Bioengineering, Clemson University, 401-1 Rhodes Engineering Research Center, Clemson, SC, 29634, USA

    Anastasia Frank-Kamenetskii & Brian W. Booth

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  1. Anastasia Frank-Kamenetskii
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  2. Brian W. Booth
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Correspondence to Brian W. Booth.

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Frank-Kamenetskii, A., Booth, B.W. Redirecting Normal and Cancer Stem Cells to a Mammary Epithelial Cell Fate. J Mammary Gland Biol Neoplasia 24, 285–292 (2019). https://doi.org/10.1007/s10911-019-09439-x

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  • DOI: https://doi.org/10.1007/s10911-019-09439-x

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