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Does the Mouse Mammary Gland Arise from Unipotent or Multipotent Mammary Stem/Progenitor Cells?

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

The presence of long-lived lineage restricted progenitor and multipotent progenitor cells in adult mouse mammary gland for cancer development is compelling. Mammary cancers are phenotypically diverse This might be explained by transformation of long-lived, lineage-limited progenitor subpopulations. Mammary multipotent epithelial stem cells and their environmental niches must be considered, since their niche(s), once empty might be occupied by lineage-limited progenitors that are proximal. The existence of premalignant mammary populationst that manifest characteristics of lineage limitation argues strongly for this proposition.

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Authors and Affiliations

  1. Mammary Stem Cell Biology, BRL,CCR, NCI, NIH, Bethesda, MD, 20892, USA

    Gilbert H. Smith

  2. Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA

    Daniel Medina

Authors
  1. Gilbert H. Smith
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  2. Daniel Medina
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Correspondence to Gilbert H. Smith.

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Smith, G.H., Medina, D. Does the Mouse Mammary Gland Arise from Unipotent or Multipotent Mammary Stem/Progenitor Cells?. J Mammary Gland Biol Neoplasia 23, 1–3 (2018). https://doi.org/10.1007/s10911-018-9394-2

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  • DOI: https://doi.org/10.1007/s10911-018-9394-2

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