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The Role of Knowledge on Genetic Counseling and Testing in Black Cancer Survivors at Increased Risk of Carrying a BRCA1/2 Mutation

  • Original Research
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Journal of Genetic Counseling

Abstract

Genetic counseling and testing (GCT) for hereditary breast and ovarian cancers (HBOC) can inform treatment decisions in survivors. Black women at risk of HBOC have lower GCT engagement. There is limited data about Black survivors’ experiences. The goals of this study were to: 1) examine the factors associated with HBOC knowledge and 2) assess the impact of knowledge on GCT engagement in a sample of Black survivors at risk of HBOC. Fifty Black at-risk breast/ovarian cancer survivors participated in a telephone-based survey. GCT use was measured across a continuum (awareness, referral, and use). The primary predictor variable was HBOC knowledge. Other clinical, socio-demographic, and psychosocial variables were included. Multiple linear and ordinal regression models (knowledge as the outcome and GCT as the outcome) assessed the predictors of knowledge and GCT engagement. Less than half (48 %) of survivors were referred to or used GCT services. Knowledge was moderate (M = 7.78, SD = 1.61). In the multivariable analysis, lower age (β = −.34, p = .01) and lower stage (β = −.318, p = .017) were associated with higher knowledge. Higher knowledge (β = .567, p = .006) and higher self-efficacy (β = .406, p = .001) were significantly associated with GCT engagement. Future interventions directed at increasing knowledge, self-efficacy, and improving the referral process are warranted.

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Acknowledgments

This study was funded by the Jess and Mildred Fisher Center for Familial Cancer Research (award # 2007-01, PI: Dr. Sheppard), the National Cancer Institute (award # R01CA154848, PI: Dr. Sheppard) and the Cancer Center Support Grant (P30CA051008).

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Authors and Affiliations

  1. Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3300 Whitehaven St. NW, Suite 4100, Washington, DC, 20007, USA

    Alejandra Hurtado-de-Mendoza & Vanessa B. Sheppard

  2. Department of Mathematics and Statistics, American University, Washington, DC, USA

    Monica C. Jackson

  3. Capital Breast Care Center, MedStar Georgetown University Hospital/Lombardi Comprehensive Cancer Center, Washington, DC, USA

    Lyndsay Anderson

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  1. Alejandra Hurtado-de-Mendoza
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  2. Monica C. Jackson
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  3. Lyndsay Anderson
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  4. Vanessa B. Sheppard
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Correspondence to Alejandra Hurtado-de-Mendoza.

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Alejandra Hurtado-de-Mendoza, Monica C. Jackson, Lyndsay Anderson and Vanessa B. Sheppard declare that they have no conflict of interest.

Human Studies and Informed Consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 (5). Informed consent was obtained from all patients for being included in the study.

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Hurtado-de-Mendoza, A., Jackson, M.C., Anderson, L. et al. The Role of Knowledge on Genetic Counseling and Testing in Black Cancer Survivors at Increased Risk of Carrying a BRCA1/2 Mutation. J Genet Counsel 26, 113–121 (2017). https://doi.org/10.1007/s10897-016-9986-1

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