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Fabrication of a Sensitive Biosensing System for Cu2+ ion Detection by Gold-Decorated Graphene Oxide Functionalized with Gly-Gly-His

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Abstract

Incorporation of nanomaterials and nanostructures into sensors causes remarkable advances in device operation due to sensitivity, selectivity, multiplexed detection capability, and portability. In this study, a nanographene sensor coated with gold nanoparticles and tripeptide Gly–Gly–His was designed for Cu2+ ion detection at low concentrations. Graphene oxide synthesized by the modified Hummer’s method and analyzed by UV–Vis spectrometry, x-ray diffraction (XRD), and transmission electron microscopy (TEM). The optimum conditions based on the maximum gold loading were evaluated 71 min for incubation time and 1 for HAuCl4/HEPES concentration ratio. Gold-coating on graphene oxide was approved by TEM, UV–vis spectrometry, XRD, and FTIR. The EDC/Sulfo-NHS method was used to stabilize Gly-Gly-His to graphene oxide-gold, which has a high affinity toward Cu. The performance mechanism of this nanosystem was based on the localized surface plasmon resonance (LSPR) property of gold nanoparticles. The sensor was extremely selective and sensitive to Cu2+ with the detection limit of 8.83 nM without cross-binding to other metal ions. The response time was evaluated about 9 min. The GO-Au-GGH biosensor was also very stable and easily reused, which further confirms it as an efficient and sensitive Cu2+ ion detection device.

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Fig. 1

modified by MUA (dotted line), GO–AuNPs–MUA activated by EDC/NHS (dashed line), GO–AuNPs–GGH (double solid line)

Fig. 2

modified by MUA (dotted line), and final NP: GO-AuNPs-GGH (dashed line)

Fig. 3
Fig. 4

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Authors and Affiliations

  1. School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran

    Farnoosh Ostadakbari & Hamid Rashedi

  2. Department of Life Science Engineering, Faculty of New Science and Technologies, University of Tehran, Tehran, Iran

    Fatemeh Yazdian & Amirhossein Ghaemi

  3. Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Bibi Fatemeh Haghirosadat

  4. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran

    Marzieh Azizi

Authors
  1. Farnoosh Ostadakbari
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  2. Fatemeh Yazdian
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  3. Hamid Rashedi
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  4. Amirhossein Ghaemi
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  5. Bibi Fatemeh Haghirosadat
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  6. Marzieh Azizi
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Correspondence to Fatemeh Yazdian or Hamid Rashedi.

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Ostadakbari, F., Yazdian, F., Rashedi, H. et al. Fabrication of a Sensitive Biosensing System for Cu2+ ion Detection by Gold-Decorated Graphene Oxide Functionalized with Gly-Gly-His. J Clust Sci 33, 2617–2624 (2022). https://doi.org/10.1007/s10876-021-02169-3

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  • DOI: https://doi.org/10.1007/s10876-021-02169-3

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