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MAGT1 Gene Mutation is Associated with Myositis and CD127 Expression Downregulation

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Fig. 1

Data Availability

Data are available upon reasonable request to the corresponding author.

Abbreviations

CK:

Creatine kinase

CyTOF:

Time-of-flight mass cytometry

EBER:

Epstein-Barr virus-encoded RNA

EBV:

Epstein-Barr virus

EEG:

Electroencephalogram

EMG:

Electromyography

FDG:

Fluorodeoxyglucose

IVIG:

Intravenous immunoglobulin

LEV:

Levetiracetam

MAGT1:

Magnesium transporter protein 1

PET-CT:

Positron Emission Tomography-Computed Tomography

TCS:

Tonic-clonic seizures

VPA:

Sodium valproate

XMEN:

X-linked immunodeficiency with Magnesium defect, Epstein-Barr virus (EBV) infection, and Neoplasia

References

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Acknowledgements

We would like to thank all the participants for their cooperation in this study.

Funding

This study was supported by Shanghai Municipal Science and Technology Major Project (No.2018SHZDZX01) and ZJLab.

Author information

Author notes

  1. Sheng Chen and Xuan Wang contributed equally to this study.

Authors and Affiliations

  1. Department of Neurology, Huashan Hospital Fudan University, No.12 Middle Wulumuqi Road, Shanghai, China

    Sheng Chen, Chong Sun, Chong-Bo Zhao & Jie Lin

  2. Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China

    Sheng Chen

  3. Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China

    Sheng Chen

  4. Department of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China

    Xuan Wang

Authors
  1. Sheng Chen
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  2. Xuan Wang
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  3. Chong Sun
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  4. Chong-Bo Zhao
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  5. Jie Lin
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Contributions

S.C. and X.W. performed experiments, analyzed results, and drafted the manuscript; X.W., C.S., C.B.Z., and J.L. were responsible for data collection and interpretation; J.L. designed the study and revised the manuscript.

Corresponding author

Correspondence to Jie Lin.

Ethics declarations

Ethics Approval

This study was approved by the Ethics Committee of Huashan Hospital Fudan University.

Consent to Participate

Written informed consent was signed by each participant before inclusion in the study.

Consent for Publication

Informed consent was obtained from the study subjects prior to publication.

Conflict of Interest

The authors declare no conmpeting interests.

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Chen, S., Wang, X., Sun, C. et al. MAGT1 Gene Mutation is Associated with Myositis and CD127 Expression Downregulation. J Clin Immunol 43, 315–318 (2023). https://doi.org/10.1007/s10875-022-01384-5

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  • DOI: https://doi.org/10.1007/s10875-022-01384-5

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