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Spontaneous alternans in Brugada ECG morphology

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Abstract

A 23-year-old man presented with sick sinus syndrome and Brugada-like ECG pattern. Coved type ECG (type 1) converted to saddleback configuration (type 2) when R-R interval decreased and it changed to coved type pattern with increasing R-R cycle length. During stable heart rate, there was no change in Brugada ECG pattern. The R-R interval effect on these patterns can be explained by intensity or kinetics of ion currents and autonomic tone.

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References

  1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 1992;20:1391–1396.

    Article  PubMed  CAS  Google Scholar 

  2. Morita H, Kusano-Fukushima K, Nagase S, Fujimoto Y, Hisamatsu K, Fujio H, Haraoka K, Kobayashi M, Morita ST, Nakamura K, Emori T, Matsubara H, Hina K, Kita T, Fukatani M, Ohe T. Atrial fibrillation and atrial vulnerability in patients with Brugada syndrome. J Am Call Cardiol 2002;40:1437–1444.

    Article  Google Scholar 

  3. Takehara N, Makita N, Kawabe J, Sato N, Kawamura Y, Kitabatake A, Kikuchi K. A cardiac sodium channel mutation identified in Brugada syndrome associated with atrial standstill. J Intern Med 2004;255:137–142.

    Article  PubMed  CAS  Google Scholar 

  4. Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, Corrado D, Hauer RN, Kass RS, Nademanee K, Periori SG, Towbin JA. Study group on the molecular basis of arrhythmias of the European Society of Cardiology: Proposed diagnostic criteria for the Brugada syndrome. Eur Heart J 2002;23:1648–1654.

    PubMed  CAS  Google Scholar 

  5. Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, Corrado D, Hauer RN, Kass RS, Nademanee K, Periori SG, Towbin JA. Study group on the molecular basis of arrhythmias of the european society of cardiology: Proposed diagnostic criteria for the Brugada syndrome: Consensus report. Circulation 2002;106:2514–2519.

    Article  PubMed  Google Scholar 

  6. Antzelevitch C, Brugada P, Borggrefe M, Brugada J, Brugada R, Corrado D, Gussak I, LeMarec H, Nademanee K, Perez Riera AR, Shimizu W, Schulze-Bahr E, Tan H, Wilde A. Brugada syndrome, Report of the second consensus conference, Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation 2005;111:659–670.

    Article  PubMed  Google Scholar 

  7. Nishizaki M, Sakurada H, Ashikaga T, Yamawake N, Fujii H, Arita M, Isobe M, Hiraoka M. Effects of glucose–induced insulin secretion on ST segment elevation in the Brugada syndrome. J Cardiovasc Electrophysiol 2003;14:243–249.

    Article  PubMed  Google Scholar 

  8. Nishizaki M, Fujii H, Sakurada H, Kimura A, Hiraoka M. Spontaneous T wave alternans in a patient with Brugada syndrome-responses to intravenous administration of class 1 antiarrhythmic drug, glucose tolerance test and atrial pacing. J Cardiovasc Electrophysiol 2005;16:217–220.

    Article  PubMed  Google Scholar 

  9. Antzelevitch C. The Brugada syndrome: Ionic basis and arrhythmia mechanism. J Cardiovasc Electrophysiol 2001;12:268–272.

    Article  PubMed  CAS  Google Scholar 

  10. Yan GX, Antzelevitch C. Cellular basis for the Brugada syndrome and other mechanisms of arrhythmogenesis associated with ST-segment elevation. Circulation 1999;10:1660–1666.

    Google Scholar 

  11. Grant AO. Electrophysiological basis and genetics of Brugada syndrome. J Cardiovasc Electrophysiol 2005;16:S3–S7.

    Article  PubMed  Google Scholar 

  12. Alings M, Wilde A. Brugada syndrome, clinical data and suggested pathophysiological mechanism. Circulation 1999;99:666–673.

    PubMed  CAS  Google Scholar 

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Correspondence to Amir Farjam Fazelifar.

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Fazelifar, A.F., Haghjoo, M., Arya, A. et al. Spontaneous alternans in Brugada ECG morphology. J Interv Card Electrophysiol 15, 131–134 (2006). https://doi.org/10.1007/s10840-006-8263-x

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  • DOI: https://doi.org/10.1007/s10840-006-8263-x

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