Abstract
Aims
Hypertensive disorders of pregnancy (HDP) is a unique disease during gestational period, which is detrimental to pregnancy outcome. This study examined the clinical significance of long non-coding RNA GAS5 in gestational hypertension (GH) and preeclampsia (PE), aiming to explore potential biomarkers for the disease detection.
Methods
180 pregnant women with HPD including 90 cases with GH and 90 cases with PE, and another 100 healthy pregnant women were enrolled. Serum GAS5 levels were measured by RT-qPCR method. The diagnostic performance of GAS5 was assessed in GH and PE through plotting receiver operating characteristic (ROC) curve. Logistic regression was applied for the identification of independent factors.
Results
Elevated serum GAS5 was identified in GH patients, and its diagnostic performance in discriminating GH cases from healthy people was determined by ROC curve. Serum GAS5 was positively associated with SBP, DBP, LDL-C and CRP values. Cases with PE had an increased serum GAS5 level relative to those with GH. Serum GAS5 was identified to be an independent predictor for PE, and can differentiate PE cases from GH ones. with a good diagnositc performance. Cases with high levels of serum GAS5 had a high risk of poor pregnancy outcomes.
Conclusion
Elevated serum GAS5 could serve as an effective diagnostic biomarker in discriminating GH patients from healthy people by first trimester screening. Detection of serum GAS5 level has a certain predictive value for PE.
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Data availability
The data used and analyzed can be obtained from the corresponding author under a reasonable request.
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The experimental procedures were all in accordance with the guideline of the Ethics Committee of Shengli Oilfield Central Hospital and has approved by the Ethics Committee of Shengli Oilfield Central Hospital. This study complies with the Declaration of Helsinki.
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Wang, L., Chen, J., Li, H. et al. Expression of long non-coding RNA GAS5 by first trimester screening predicts the occurrence of gestational hypertension and pre-eclampsia. J Assist Reprod Genet (2024). https://doi.org/10.1007/s10815-024-03093-x
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DOI: https://doi.org/10.1007/s10815-024-03093-x