Abstract
Purpose
To investigate the effects of a carrier’s sex and age on the segregation patterns of the trivalent of Robertsonian translocations.
Methods
This retrospective study was designed to analyze the segregation patterns of the trivalent and euploidy rates of blastocysts. Data were collected from 154 couples with Robertsonian translocation (77 with a female carrier and 77 with a male carrier). Embryos were diagnosed via array comparative genomic hybridization between January 2013 and July 2017. The segregation patterns of the trivalent of 604 blastocysts were analyzed according to the carrier’s sex and age.
Results
The proportion of alternate segregation was significantly higher (82.9% vs. 55.2%) in the male carriers than in the female carriers of Robertsonian translocation, and the proportion of adjacent segregation was significantly lower (16.8% vs. 42.6%), with no difference in 3:0 segregation. The segregation patterns were similar in same-sex carriers when analyzed according to the type of translocation. The carrier’s age had no influence on the segregation patterns of the trivalent.
Conclusions
The proportions of the trivalent’s meiotic segregation pattern differ significantly according to the carrier’s sex in Robertsonian translocations and are independent of the carrier’s age. A significantly higher proportion of alternate segregation for normal or balanced chromosome contents was observed in the blastocysts of the male carriers than in those of the female carriers.
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Funding
This study received financial support from the National Key Research and Development Program of China (2016YFC1000202); the National Natural Science Foundation of China (81671522); and the Innovative Fund of Reproductive Hospital Affiliated to Shandong University (20171114, 20171111).
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Zhang, L., Jiang, W., Zhu, Y. et al. Effects of a carrier’s sex and age on the segregation patterns of the trivalent of Robertsonian translocations. J Assist Reprod Genet 36, 1963–1969 (2019). https://doi.org/10.1007/s10815-019-01534-6
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DOI: https://doi.org/10.1007/s10815-019-01534-6