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Neonatal outcomes among twins stratified by method of conception: secondary analysis of maternal fetal medicine (MFMU) network database

  • Assisted Reproduction Technologies
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Abstract

Purpose

To investigate whether twin pregnancies conceived by different forms of fertility treatments are associated with adverse neonatal outcomes and to examine the difference in maternal and obstetrical characteristics between patients.

Methods

Our study was a retrospective analysis of twin pregnancies conceived by fertility treatments from a prospectively collected database. Treatments were stratified into two groups: group 1 (ART) consisted of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), and group 2 (non-ART) included intrauterine insemination (IUI) and ovulation induction (OI). Composite neonatal morbidity included respiratory distress syndrome, intraventricular hemorrhage, leukomalacia, chronic lung disease, and death prior to discharge.

Results

There were 460 neonates in our study; among them, 67% (n = 310) were in group 1, and 33% (n = 150) in group 2. Group 1 patients were more likely to be older (p = 0.004), nulliparous (p = 0.01), delivered twins with lower birth weights (2278 g ± 605 vs. 2427 ± 519, p = 0.009), and had more deliveries < 32 weeks gestation (p = 0.001). In multivariable Poisson regression model, only neonatal intensive care unit admission rate was increased for group 1 twins (aRR = 1.27, 95% CI 1.003–1.60).

Conclusions

After adjusting for confounders, twins conceived via ART compared to non-ART had similar neonatal outcomes. These data can help when counseling this patient population and assist in planning larger prospective cohorts.

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Authors and Affiliations

  1. Department of Obstetrics & Gynecology, McGovern Medical School at the University of Texas Health Science Center, 6431 Fannin St, Suite 3.214, Houston, TX, 77030, USA

    Jaimin S. Shah, Susan Hosseini Nasab & Han-Yang Chen

  2. Department of Reproductive Endocrinology and Infertility, Baylor College of Medicine, Houston, TX, USA

    Neil Chappell & Amy Schutt

  3. Department of Maternal & Fetal Medicine, McGovern Medical School at the University of Texas Health Science Center, Houston, TX, USA

    Hector Mendez-Figueroa

Authors
  1. Jaimin S. Shah
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  2. Susan Hosseini Nasab
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  3. Neil Chappell
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  4. Han-Yang Chen
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  5. Amy Schutt
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  6. Hector Mendez-Figueroa
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Corresponding author

Correspondence to Jaimin S. Shah.

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The authors declare that they have no conflict of interest.

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Shah, J.S., Nasab, S.H., Chappell, N. et al. Neonatal outcomes among twins stratified by method of conception: secondary analysis of maternal fetal medicine (MFMU) network database. J Assist Reprod Genet 35, 1011–1017 (2018). https://doi.org/10.1007/s10815-018-1149-x

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  • DOI: https://doi.org/10.1007/s10815-018-1149-x

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