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Anti-diabetic potential of selected Malaysian seaweeds

  • 5th Congress of the International Society for Applied Phycology
  • Published:
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Abstract

The emergence of type 2 diabetes mellitus (T2DM) as the pre-eminent global non-infectious disease has driven the search for new anti-diabetic strategies including utilising traditional food and herbs. In this investigation, we describe the anti-diabetic potential of six selected Malaysian seaweed species against recognised pharmacological targets. Specifically, we measured their ability to inhibit α-glucosidase and dipeptidyl-peptidase-4 (DPP-4) and also their ability to stimulate incretin hormone secretion in vitro. Crude water extracts of Halimeda macroloba, Padina sulcata, Sargassum binderi and Turbinaria conoides possessed potent inhibitory activities against α-glucosidase and DPP-4. The highest inhibitory activity against α-glucosidase was found in water extracts of the green seaweed species H. macroloba with an IC50 value of 6.388 mg mL−1. Crude water extracts of the brown seaweeds studied namely P. sulcata, S. binderi and T. conoides, exhibited potent DPP-4 inhibition compared with the green seaweed H. macroloba. The brown seaweed also stimulates secretion of glucose-dependent insulinotrophic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) from pGIP neo STC-1 cells in vitro. H. macroloba stimulated GLP-1 secretion but not secretion of GIP.

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Acknowledgements

This study was funded by the University of Malaya via RG109-11SUS and UMQUB2A-2011 research grants. Funding and support from Queen’s University Belfast is also acknowledged. Yao Xian Chin is a recipient of MyPhD Scholarship under the MyBrain15 Programme, Malaysian Ministry of Education.

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Authors and Affiliations

  1. Institute of Ocean and Earth Sciences, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Yao Xian Chin, Phaik Eem Lim, Siew Moi Phang & Yusrizam Sharifuddin

  2. Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Yao Xian Chin, Phaik Eem Lim, Siew Moi Phang & Yusrizam Sharifuddin

  3. School of Biological Sciences, Medical Biology Centre, Queen’s University Belfast, Belfast, BT9 7AE, UK

    Christine A. Maggs

  4. Institute for Global Food Security, School of Biological Sciences, Queen’s University Belfast, Belfast, BT9 5AG, UK

    Brian D. Green

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  1. Yao Xian Chin
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  2. Phaik Eem Lim
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  3. Christine A. Maggs
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  4. Siew Moi Phang
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Correspondence to Yusrizam Sharifuddin.

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Chin, Y.X., Lim, P.E., Maggs, C.A. et al. Anti-diabetic potential of selected Malaysian seaweeds. J Appl Phycol 27, 2137–2148 (2015). https://doi.org/10.1007/s10811-014-0462-8

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