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Corneal biomechanics and their association with severity of lens dislocation in Marfan syndrome

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Abstract

Purpose

To investigate corneal biomechanical properties and its associations with the severity of lens dislocation in patients with Marfan syndrome.

Methods

A total of 30 patients with Marfan syndrome and 30 age-, sex- and axial length (AL)—matched controls were recruited. Corneal biomechanical parameters of both groups were measured by CorVis ST and were compared between groups. Potential associations between corneal biomechanical parameters and severity of lens dislocation were also investigated.

Results

Lower applanation 1 velocity (A1V) (0.13 ± 0.004 vs. 0.15 ± 0.003, P = 0.016), shorter applanation 2 time (A2T)(22.64 ± 0.11 vs. 22.94 ± 0.11, P = 0.013), longer peak distance (PD) (5.03 ± 0.07 vs. 4.81 ± 0.05, P = 0.008), longer radius (R) of highest concavity (7.44 ± 0.16 vs. 6.93 ± 0.14, P = 0.012), greater Ambrosio relational thickness horizontal (ARTh) (603 ± 20 vs. 498 ± 12, P < 0.001), and integrated radius (IR) (8.32 ± 0.25 vs. 8.95 ± 0.21, P = 0.033) were detected among Marfan eyes compared with controls (all P < 0.05). Marfan individuals with more severe lens dislocation tended to have increased stiffness parameter as longer A1T, slower A1V, shorter A2T, slower application 2 velocity (A2V), smaller PD and smaller Distance Amplitude (DA) (P < 0.05).

Conclusion

Marfan patients were detected to have increased corneal stiffness compared with normal subjects. Corneal biomechanical parameters were significantly associated with the severity of lens dislocation in Marfan patients.

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Data availability

Data are available upon reasonable request. Data are available upon reasonable request to email jingm@mail2.sysu.edu.cn.

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Funding

This work was supported by National Natural Science Foundation of China (81873673, 81900841) and Guangdong Basic and Applied Basic Research Foundation (2022A1515011181).

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Author notes

  1. Guangming Jin, Minjie Zou and Longhui Li share first authorship.

Authors and Affiliations

  1. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China

    Guangming Jin, Minjie Zou, Longhui Li, Zhenzhen Liu, Haotian Qi & Danying Zheng

  2. Albany Medical College, 49 New Scotland Ave, Albany, NY, USA

    Charlotte Young

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  1. Guangming Jin
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Contributions

Designed the study, initiated the collaborative project, revised the paper (DY Zheng); Monitored data collection, wrote the statistical analysis plan and drafted the paper (GM Jin, LH Li and MJ Zou); Cleaned and analyzed the data (ZZ Liu, Charlotte Young and HT Qi); administrative, technical or logistic support (DY Zheng).

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Correspondence to Danying Zheng.

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The authors declare no competing interests.

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Patients or the public were not involved in the design, or conduct, or reporting, or dissemination plans of our research.

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This study was conducted in accordance with the Declaration of Helsinki and approved by Zhongshan Ophthalmic Center Institutional Review Board (2019KYPJ183).

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Jin, G., Zou, M., Li, L. et al. Corneal biomechanics and their association with severity of lens dislocation in Marfan syndrome. Int Ophthalmol 44, 148 (2024). https://doi.org/10.1007/s10792-024-03079-9

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