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Investigation of optic nerve function in Behçet’s patients with optic disc hyperfluorescence in fundus fluorescein angiography

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Abstract

Purpose

The aim was to investigate the changes in optic nerve function that may help in the diagnosis of subclinical optic nerve involvement in patients with Behçet’s disease (BD) and isolated optic disc (OD) hyperfluorescence in fluorescein angiography (FA).

Materials and methods

Three groups were formed; BD patients with isolated OD hyperfluorescence in FA, BD patients without ocular involvement (normal FA) and control group. A total of 88 eyes of 45 patients were included. The groups were compared in terms of OCT-RNFL, contrast sensitivity and VEP latency.

Results

When the OCT-RNFL values were compared, there was a significant difference between the control group and Behçet’s patients with normal FA. Contrast sensitivity values differed significantly among the groups, and the lowest mean contrast sensitivity was observed in the group with OD hyperfluorescence (p < 0.05).

Conclusion

As far as we know, this is the first publication that investigates optic nerve function in BD patients with isolated OD hyperfluorescence in FA. Assessment with FA of asymptomatic BD patients with visual complaints and low contrast sensitivity may be helpful at early detection of inflammatory optic neuropathy by close follow-up in patients with OD hyperfluorescence.

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Data availability

All data generated or analyzed during this study are included in this published article.

Code availability

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Funding

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Bezmialem Vakıf University, Istanbul, Turkey

    Atilla Şahin

  2. Department of Ophthalmology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, 34098, Istanbul, Turkey

    Bilge Batu Oto & Didar Uçar

  3. Department of Neurology, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul, Turkey

    Nurten Uzun Adatepe

Authors
  1. Atilla Şahin
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  2. Bilge Batu Oto
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  3. Nurten Uzun Adatepe
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  4. Didar Uçar
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Contributions

The authors contribution to the paper as follows: study conception and design were developed by AŞ and DU; data collection was collected by AŞ and BBO; analysis and interpretation of results was performed by AŞ, NUA and DU; prepared figures and tables were prepared by AŞ and BBO; draft manuscript preparation was done by DU, AŞ and BBO. All authors reviewed the results and approved the final version of the manuscript.

Corresponding author

Correspondence to Didar Uçar.

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The authors declare no competing interests.

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The authors declare that they have no conflict of interest.

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The study protocol was approved by the local ethical committee.

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Written informed consent was obtained from all participants in accordance with the Declaration of Helsinki.

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Şahin, A., Batu Oto, B., Uzun Adatepe, N. et al. Investigation of optic nerve function in Behçet’s patients with optic disc hyperfluorescence in fundus fluorescein angiography. Int Ophthalmol 44, 76 (2024). https://doi.org/10.1007/s10792-024-02927-y

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  • DOI: https://doi.org/10.1007/s10792-024-02927-y

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