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Changes in asphericity of anterior and posterior corneal surfaces for mild–moderate and high myopia after topography-guided FS-LASIK

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Abstract

Purpose

To compare changes in asphericity of anterior and posterior corneal surfaces for different myopia patients after corneal topography-guided femtosecond-assisted laser in situ keratomileuses (FS-LASIK), and to analyze correlations between asphericity of corneal surfaces and preoperative spherical equivalence (SEQ).

Methods

In this prospective study, 59 patients who underwent corneal topography-guided FS-LASIK surgery were enrolled and divided into the mild–moderate myopia group (67 eyes) and the high myopia group (44 eyes). Postoperative follow-ups were performed at 1, 3, and 6 months. Postoperative changes in aspherical coefficient (Q values), corneal higher-order aberrations (HOAs), and spherical aberrations (Z40) were compared between the two groups. Relevance between Q value changes and SEQ, HOAs, and Z40 as well as between SEQ and changes of HOAs and Z40 was analyzed.

Results

There was a significant increase in Q values of the anterior (each diameter) and posterior (6–8 mm) corneal surface in both groups than before surgery (P < 0.001). Q values of corneal anterior (each diameter) and posterior (7–9 mm) surface in the high group were considerably larger than the mild–moderate group (P < 0.05). Corneal anterior surface HOAs and Z40 values in the high group largely exceeded those of the mild–moderate group (P < 0.001). The preoperative SEQ was linearly correlated with postoperative anterior Q change (ΔQ), HOAs change (ΔHOAs), and spherical aberration change (ΔZ40).

Conclusion

The changes of corneal asphericity in patients with high myopia were greater than mild–moderate myopia, with more corneal HOAs and Z40 introduced when corneal topography-guided FS-LASIK was conducted.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on request.

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Funding

This work is supported by the Tianjin Key Clinical Disciplines (Specialties) Construction Project (TJLCZDXKM013).

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Author notes

  1. Yuan Wu and Shengshu Sun contributed equally to this work. Yuan Wu and Shengshu Sun have contributed equally as first authors.

Authors and Affiliations

  1. Tianjin Medical University Eye Hospital, College of Optometry, Institute of Ophthalmology, National Clinical Medical Research Center for Eye, Ear, Nose and Throat Diseases, Tianjin Branch, Tianjin Key Laboratory of Retinal Function and Diseases, Tianjin, 300384, China

    Yuan Wu, Shengshu Sun, Zhanglin Liu, Shuhan Wang, Guiqin Wang, Shaozhen Zhao, Ruihua Wei & Yue Huang

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  1. Yuan Wu
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Contributions

YW and SSS have equal first authors. Study design (WY, HY, WSH); data collecting (WY, LZL, WGQ); data and statistical analysis (SSS, WY); writing the manuscript (SSS, WY); revision of the manuscript (HY, ZSZ, WRH).

Corresponding author

Correspondence to Yue Huang.

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Conflict of interest

The authors declare no competing financial interest.

Ethical approval

This study was performed in full compliance with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Tianjin Medical University (No. ChiCTR2100045632).

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Full and informed consent was given by each subject for these experiments.

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Wu, Y., Sun, S., Liu, Z. et al. Changes in asphericity of anterior and posterior corneal surfaces for mild–moderate and high myopia after topography-guided FS-LASIK. Int Ophthalmol 42, 3555–3565 (2022). https://doi.org/10.1007/s10792-022-02356-9

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