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Evaluation of systemic immune-inflammation index level as a novel marker for severity of noninfectious uveitis

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Abstract

Purpose

To evaluate the association of systemic immune-inflammation index (SII) levels, neutrophil/lymphocyte ratio (NLR), and platelet/lymphocyte ratio (PLR) with severity of noninfectious uveitis.

Methods

This retrospective study included 46 patients with noninfectious uveitis (uveitis group) and 46 age- and sex-matched healthy subjects (control group). The demographic and ocular findings, localization, and activity of uveitis were recorded at the time of onset evaluation. SII, NLR, and PLR levels of patients were compared between the groups.

Results

SII, NLR, and PLR levels were significantly higher in uveitis group when compared to control group (p < 0.001, p = 0.005, and p = 0.001, respectively). While SII and NLR were significantly higher in severe anterior uveitis than mild anterior uveitis (p = 0.006 and p = 0.021, respectively), only SII was significantly higher in severe posterior and panuveitis than mild ones (p = 0.038).

Conclusion

SII, as a novel inflammation index, may be more significant tool than NLR and PLR in determining the severity of the uveitis. Furthermore, SII may be a potential useful index in clinical practice to follow-up and manage these patients by monitoring response to anti-inflammatory treatment modalities.

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Data availability

All data are included in this paper.

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Funding

The authors declared that this study received no funding.

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Authors and Affiliations

  1. Department of Ophthalmology, Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Antakya, Hatay, Turkey

    Bengi Ece Kurtul, Ayse Idil Cakmak, Ahmet Elbeyli, Sait Coskun Ozcan & Deniz Ozarslan Ozcan

  2. Department of Rheumatology, Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Antakya, Hatay, Turkey

    Gezmis Kimyon

Authors
  1. Bengi Ece Kurtul
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  2. Ayse Idil Cakmak
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  3. Ahmet Elbeyli
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  4. Sait Coskun Ozcan
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  5. Deniz Ozarslan Ozcan
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Contributions

BEK, AIC, AE, SCO, DOO, and GK contributed to conception or design of the work, the acquisition, analysis, and interpretation of data; BEK drafted the work or revised it critically for important intellectual content. BEK, AIC, AE, SCO, DOO, and GK agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Correspondence to Bengi Ece Kurtul.

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No conflict of interest was declared by the authors.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors. All authors approved the version to be published.

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Informed consent was obtained from all individual participants included into the study.

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Kurtul, B.E., Cakmak, A.I., Elbeyli, A. et al. Evaluation of systemic immune-inflammation index level as a novel marker for severity of noninfectious uveitis. Int Ophthalmol 41, 3615–3622 (2021). https://doi.org/10.1007/s10792-021-01924-9

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