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Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab

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Abstract

Purpose

This study searched for early predictive vascular biomarkers for visual outcomes in eyes with macular edema caused by branch retinal vein occlusion (BRVOME).

Methods

Twenty-four eyes of 24 subjects with BRVOME were treated with the intravitreal injection of ranibizumab (IVR) for at least 6 months. We measured mean blur rate (MBR) in the optic nerve head (ONH) and vessel density (VD) in the macula with laser speckle flowgraphy and optical coherence tomography angiography, respectively.

Results

Six-month post-IVR best-corrected visual acuity (BCVA) was correlated positively with age, pre-IVR BCVA, 1-month post-IVR BCVA, 3-month post-IVR BCVA and pre-IVR systolic blood pressure (P < 0.001, P < 0.001, P < 0.001, P < 0.001 and P = 0.02, respectively) and negatively with pre-IVR overall MBR, 1-month post-IVR overall MBR, 6-month post-IVR overall MBR, 3-month post-IVR deep retinal capillary plexus (DCP) VD and 6-month post-IVR DCP VD (P = 0.03, P = 0.03, P = 0.02, P = 0.01 and P = 0.005, respectively). Furthermore, a multiple regression analysis showed that pre-IVR overall MBR (β =  − 0.67, P = 0.009) was among independent prognostic factors predicting 6-month post-IVR BCVA. Six-month post-IVR DCP VD was also correlated with overall MBR at all time points.

Conclusion

ONH blood flow may be a pre-IVR biomarker of both visual outcomes and post-IVR deep macular microcirculation in eyes with BRVOME.

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Acknowledgements

The principal investigator, Dr. Toshifumi Asano, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the analysis. No authors have any potential conflicts of interest to disclose. This paper was supported by JST grants from JSPS KAKENHI Grants-in-Aid for Scientific Research (C) (H.K.40361092). The funders had no role in the design or conduct of the study; collection, management, analysis or interpretation of the data; preparation, review or approval of the manuscript; or the decision to submit the manuscript for publication.

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Authors and Affiliations

  1. Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan

    Toshifumi Asano, Hiroshi Kunikata, Masayuki Yasuda & Toru Nakazawa

  2. Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Hiroshi Kunikata & Toru Nakazawa

  3. Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Koji M. Nishiguchi & Toru Nakazawa

  4. Division of Clinical Cell Therapy, United Centers for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Toshiaki Abe

  5. Department of Ophthalmic Imaging and Information Analytics, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Toru Nakazawa

Authors
  1. Toshifumi Asano
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  2. Hiroshi Kunikata
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  3. Masayuki Yasuda
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  4. Koji M. Nishiguchi
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  5. Toshiaki Abe
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Contributions

TA, HK and TN were involved in design and conduct of the study. TA, HK, MY, KN, TA and TN were involved in preparation, collection, management, analysis and interpretation of the data. TN approved the manuscript. HK wrote the main manuscript text. TA and HK prepared all tables and all figures, and all authors reviewed the manuscript.

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Correspondence to Hiroshi Kunikata.

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Asano, T., Kunikata, H., Yasuda, M. et al. Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab. Int Ophthalmol 41, 151–162 (2021). https://doi.org/10.1007/s10792-020-01562-7

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