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Anti-VEGF treatment switch in neovascular age-related macular degeneration: a comparison of aflibercept versus ranibizumab after a single-dose switch

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Abstract

Purpose

To determine the effect achieved from a single dose of anti-VEGF treatment switch, in patients with nAMD previously treated with bevacizumab, switched to either aflibercept or ranibizumab, and to compare the response between aflibercept and ranibizumab.

Methods

In retrospective, observational, and comparative study, patients were divided into two groups: Group 1, patients switched to aflibercept; Group 2, patients switched to ranibizumab. Paired samples t test was performed to measure differences in central macular thickness (CMT). To compare whether there were differences between groups mixed-design ANOVA was used.

Results

In Group 1, CMT changed from 360.51 to 260.16 µm, presenting a significant mean difference from PreSwitch to PostSwitch of 100.34 µm (p = 0.002, paired samples t test). In Group 2, CMT changed from 366.33 to 260.72 µm, showing a significant difference from PreSwitch to PostSwitch of 105.61 µm (p ≤ 0.000, paired samples t test). The mixed-design ANOVA compared both groups and resulted in a nonsignificant value of 0.90.

Conclusion

The effect achieved from a single dose in patients switched to aflibercept or ranibizumab reduced significantly CMT measurements. Comparing aflibercept and ranibizumab, the effect appears to be similar in both drugs, in terms of reduction of CMT.

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Authors and Affiliations

  1. Retina Department, Asociación Para Evitar la Ceguera en México, Hospital Dr. Luis Sánchez Bulnes, Vicente García Torres # 46, San Lucas Coyoacán, 04030, Mexico City, Mexico

    Guillermo Salcedo-Villanueva, Estephania Feria-Anzaldo, Juan C. Romo-Aguas, Andrés Lisker-Cervantes, Alejandra González-Dibildox, Edel Moreno-Paramo, Abraham A. Medina-Andrade, Raúl Velez-Montoya, Gerardo García-Aguirre & Virgilio Morales-Cantón

  2. Research Department, Asociación Para Evitar la Ceguera en México, Hospital Dr. Luis Sánchez Bulnes, Vicente García Torres # 46, San Lucas Coyoacán, 04030, Mexico City, Mexico

    Hugo Quiroz-Mercado

Authors
  1. Guillermo Salcedo-Villanueva
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  2. Estephania Feria-Anzaldo
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  3. Juan C. Romo-Aguas
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  4. Andrés Lisker-Cervantes
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  5. Alejandra González-Dibildox
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  6. Edel Moreno-Paramo
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  7. Abraham A. Medina-Andrade
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  8. Raúl Velez-Montoya
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  9. Gerardo García-Aguirre
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Corresponding author

Correspondence to Guillermo Salcedo-Villanueva.

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Salcedo-Villanueva, G., Feria-Anzaldo, E., Romo-Aguas, J.C. et al. Anti-VEGF treatment switch in neovascular age-related macular degeneration: a comparison of aflibercept versus ranibizumab after a single-dose switch. Int Ophthalmol 39, 2023–2031 (2019). https://doi.org/10.1007/s10792-018-1038-4

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  • DOI: https://doi.org/10.1007/s10792-018-1038-4

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