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Manifestation of meibomian gland dysfunction in patients with Sjögren’s syndrome, non-Sjögren’s dry eye, and non-dry eye controls

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Abstract

Purpose

To evaluate the manifestation of meibomian gland dysfunction in patients with Sjögren’s syndrome (SS), non-Sjögren’s syndrome dry eye (non-SS) patients, and non-dry eye controls.

Methods

We recruited 31 participants with SS dry eye, 30 participants with non-SS dry eye, and 35 healthy controls without dry eye symptoms. Noninvasive tear breakup time (NITBUT) and meibomian gland dropout score (meiboscore) were measured using the Oculus Keratograph 5 M. Meibomian gland expressibility and secretion quality were evaluated via slit lamp biomicroscopy. The correlation between measurements was analyzed.

Results

NITBUT was lower, and the meiboscore, meibomian gland expressibility, and secretion quality scores were significantly higher in the SS and non-SS groups than in the control group (p < 0.001). NITBUT was lower, and the meiboscore and meibomian gland expressibility were higher in the SS group than in the non-SS group. NITBUT correlated negatively with the meiboscore in both SS and non-SS groups and with meibomian gland expressibility in the SS group. A positive correlation was obtained between meiboscore and meibomian gland expressibility in both the SS and the non-SS groups.

Conclusion

Patients in both SS and non-SS groups exhibited greater impairment in meibomian gland function than the non-dry eye controls. SS patients had more severe meibomian gland dysfunction with poorer mean meiboscore and meibomian gland expressibility than non-SS patients.

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Acknowledgements

This study was partially supported by the CNUH Biomedical Research Institute (CRI 13906-22).

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Authors and Affiliations

  1. Department of Ophthalmology, Chonnam National University Medical School and Hospital, 42 Jebong-ro, Dong-gu, Gwangju, 501-757, South Korea

    Yeon Soo Kang, Hyo Seok Lee, Ying Li, Won Choi & Kyung Chul Yoon

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  1. Yeon Soo Kang
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  2. Hyo Seok Lee
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  3. Ying Li
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  5. Kyung Chul Yoon
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Correspondence to Kyung Chul Yoon.

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Kang, Y.S., Lee, H.S., Li, Y. et al. Manifestation of meibomian gland dysfunction in patients with Sjögren’s syndrome, non-Sjögren’s dry eye, and non-dry eye controls. Int Ophthalmol 38, 1161–1167 (2018). https://doi.org/10.1007/s10792-017-0577-4

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  • DOI: https://doi.org/10.1007/s10792-017-0577-4

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