Abstract
Glaucoma after penetrating keratoplasty is a frequently observed post-operative complication and is a risk factor for graft failure. Penetrating keratoplasty performed for aphakic and pseudophakic bullous keratopathy and inflammatory conditions are more likely to cause postoperative glaucoma compared with keratoconus and Fuchs’ endothelial dystrophy. The intraocular pressure elevation may occur immediately after surgery or in the early to late postoperative period. Early postoperative causes of glaucoma include pre-existing glaucoma, retained viscoelastic, hyphema, inflammation, pupillary block, aqueous misdirection, or suprachoroidal hemorrhage. Late causes include pre-existing glaucoma, angle-closure glaucoma, ghost cell glaucoma, suprachoroidal hemorrhage, and steroid-induced glaucoma. Determining the cause of IOP elevation can help guide therapeutic intervention. Treatments for refractory glaucoma include topical anti-glaucoma medications such as beta-adrenergic blockers. Topical carbonic anhydrase inhibitors, miotic agents, adrenergic agonists, and prostaglandin analogs should be used with caution in the post-keratoplasty patient, because of the possibility of corneal decompensation, cystoid macular edema, or persistent inflammation. Various glaucoma surgical treatments have reported success in post-keratoplasty glaucoma. Trabeculectomy with mitomycin C can be successful in controlling IOP without the corneal toxicity noted with 5-fluorouracil. Glaucoma drainage devices have successfully controlled intraocular pressure in post-keratoplasty glaucoma; this is, however, associated with increased risk of graft failure. Placement of the tube through the pars plana may improve graft success compared with implantation within the anterior chamber. In addition, cyclophotocoagulation remains a useful procedure for eyes that have refractory glaucoma despite multiple surgical interventions.
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References
Ramsay AS, Lee WR, Mohammed A (1997) Changing indications for penetrating keratoplasty in the west of Scotland from 1970 to 1995. Eye 11(Pt 3):357–360
Liu E, Slomovic AR (1997) Indications for penetrating keratoplasty in Canada, 1986–1995. Cornea 16(4):414–419
Lois N, Kowal VO, Cohen EJ, Rapuano CJ, Gault JA, Raber IM et al (1997) Indications for penetrating keratoplasty and associated procedures, 1989–1995. Cornea 16(6):623–629
Cursiefen C, Kuchle M, Naumann GO (1998) Changing indications for penetrating keratoplasty: histopathology of 1, 250 corneal buttons. Cornea 17(5):468–470
Patel NP, Kim T, Rapuano CJ, Cohen EJ, Laibson PR (2000) Indications for and outcomes of repeat penetrating keratoplasty, 1989–1995. Ophthalmology 107(4):719–724
Dobbins KR, Price FW Jr, Whitson WE (2000) Trends in the indications for penetrating keratoplasty in the midwestern United States. Cornea 19(6):813–816
Chen WL, Hu FR, Wang IJ (2001) Changing indications for penetrating keratoplasty in Taiwan from 1987 to 1999. Cornea 20(2):141–144
Cosar CB, Sridhar MS, Cohen EJ, Held EL, Alvim Pde T, Rapuano CJ et al (2002) Indications for penetrating keratoplasty and associated procedures, 1996–2000. Cornea 21(2):148–151
Edwards M, Clover GM, Brookes N, Pendergrast D, Chaulk J, McGhee CN (2002) Indications for corneal transplantation in New Zealand: 1991–1999. Cornea 21(2):152–155
Al-Towerki AE, Gonah el-S, Al-Rajhi A, Wagoner MD (2004) Changing indications for corneal transplantation at the King Khaled Eye Specialist Hospital (1983–2002). Cornea 23(6):584–588
Tabin GC, Gurung R, Paudyal G, Reddy HS, Hobbs CL, Wiedman MS et al (2004) Penetrating keratoplasty in Nepal. Cornea 23(6):589–596
Al-Yousuf N, Mavrikakis I, Mavrikakis E, Daya SM (2004) Penetrating keratoplasty: indications over a 10 year period. Br J Ophthalmol 88(8):998–1001
Yahalom C, Mechoulam H, Solomon A, Raiskup FD, Peer J, Frucht-Pery J (2005) Forty years of changing indications in penetrating keratoplasty in Israel. Cornea 24(3):256–258
Zhang C, Xu J (2005) Indications for penetrating keratoplasty in East China, 1994–2003. Graefes Arch Clin Exp Ophthalmol 243(10):1005–1009
Kang PC, Klintworth GK, Kim T, Carlson AN, Adelman R, Stinnett S et al (2005) Trends in the indications for penetrating keratoplasty, 1980–2001. Cornea 24(7):801–803
Sony P, Sharma N, Sen S, Vajpayee RB (2005) Indications of penetrating keratoplasty in northern India. Cornea 24(8):989–991
Sugar A, Meyer RF, Hood CI (1977) Epithelial downgrowth following penetrating keratoplasty in the aphake. Arch Ophthalmol 95(3):464–467
Boruchoff SA, Kenyon KR, Foulks GN, Green WR (1980) Epithelial cyst of the iris following penetrating keratoplasty. Br J Ophthalmol 64(6):440–445
Kramer SG (1987) Cystoid macular edema in keratoplasty. Trans New Orleans Acad Ophthalmol 35:219–228
Kramer SG (1981) Cystoid macular edema after aphakic penetrating keratoplasty. Ophthalmology 88(8):782–787
Karesh JW, Nirankari VS (1983) Factors associated with glaucoma after penetrating keratoplasty. Am J Ophthalmol 96(2):160–164
Guss RB, Koenig S, De La Pena W, Marx M, Kaufman HE (1983) Endophthalmitis after penetrating keratoplasty. Am J Ophthalmol 95(5):651–658
Ferry AP, Madge GE, Mayer W (1985) Epithelialization of the anterior chamber as a complication of penetrating keratoplasty. Ann Ophthalmol 17(7):414–417
Claoue C, Lewkowicz-Moss S, Easty D (1988) Epithelial cyst in the anterior chamber after penetrating keratoplasty: a rare complication. Br J Ophthalmol 72(1):36–40
Buxton JN, Seedor JA, Perry HD, Eagle RC, Pecego JA (1988) Donor failure after corneal transplantation surgery. Cornea 7(2):89–95
Simmons RB, Stern RA, Teekhasaenee C, Kenyon KR (1989) Elevated intraocular pressure following penetrating keratoplasty. Trans Am Ophthalmol Soc 87:79–91; discussion 91–93
Harris DJ Jr, Stulting RD, Waring GO 3rd, Wilson LA (1988) Late bacterial and fungal keratitis after corneal transplantation. Spectrum of pathogens, graft survival, and visual prognosis. Ophthalmology 95(10):1450–1457
Kirkness CM, Ficker LA (1992) Risk factors for the development of postkeratoplasty glaucoma. Cornea 11(5):427–432
Holland EJ, Daya SM, Evangelista A, Ketcham JM, Lubniewski AJ, Doughman DJ et al (1992) Penetrating keratoplasty and transscleral fixation of posterior chamber lens. Am J Ophthalmol 114(2):182–187
Chien AM, Schmidt CM, Cohen EJ, Rajpal RK, Sperber LT, Rapuano CJ et al (1993) Glaucoma in the immediate postoperative period after penetrating keratoplasty. Am J Ophthalmol 115(6):711–714
The Australian Corneal Graft Registry (1993) 1990 to 1992 report. Aust N Z J Ophthalmol 21(2 Suppl):1–48
Brunette I, Stulting RD, Rinne JR, Waring GO 3rd, Gemmil M (1994) Penetrating keratoplasty with anterior or posterior chamber intraocular lens implantation. Arch Ophthalmol 112(10):1311–1319
Menage MJ, Kaufman PL, Croft MA, Landay SP (1994) Intraocular pressure measurement after penetrating keratoplasty: minified Goldmann applanation tonometer, pneumatonometer, and Tono-Pen versus manometry. Br J Ophthalmol 78(9):671–676
Reinhard T, Kallmann C, Cepin A, Godehardt E, Sundmacher R (1997) The influence of glaucoma history on graft survival after penetrating keratoplasty. Graefes Arch Clin Exp Ophthalmol 235(9):553–557
Sihota R, Sharma N, Panda A, Aggarwal HC, Singh R (1998) Post-penetrating keratoplasty glaucoma: risk factors, management and visual outcome. Aust N Z J Ophthalmol 26(4):305–309
Design and methods of The Collaborative Corneal Transplantation Studies. The Collaborative Corneal Transplantation Studies Research Group (1993) Cornea 12(2):93–103
Boisjoly HM, Tourigny R, Bazin R, Laughrea PA, Dube I, Chamberland G et al (1993) Risk factors of corneal graft failure. Ophthalmology 100(11):1728–1735
Yamagami S, Suzuki Y, Tsuru T (1996) Risk factors for graft failure in penetrating keratoplasty. Acta Ophthalmol Scand 74(6):584–588
Ing JJ, Ing HH, Nelson LR, Hodge DO, Bourne WM (1998) Ten-year postoperative results of penetrating keratoplasty. Ophthalmology 105(10):1855–1865
Coster DJ (1989) Mechanisms of corneal graft failure: the erosion of corneal privilege. Eye 3(Pt 3):251–262
Tragakis MP, Brown SI (1972) The significance of anterior synechiae after corneal transplantation. Am J Ophthalmol 74(3):532–533
Chipman ML, Basu PK, Willett PJ, Cherry PM, Slomovic AR (1990) The effects of donor age and cause of death on corneal graft survival. Acta Ophthalmol (Copenh) 68(5):537–542
Kirkness CM, Ezra E, Rice NS, Steele AD (1990) The success and survival of repeat corneal grafts. Eye 4(Pt 1):58–64
Cherry PM, Pashby RC, Tadros ML, Wolf A, Chipman ML, Basu PK et al (1979) An analysis of corneal transplantation: I-graft clarity. Ann Ophthalmol 11(3):461–469
Franca ET, Arcieri ES, Arcieri RS, Rocha FJ (2002) A study of glaucoma after penetrating keratoplasty. Cornea 21(3):284–288
Ayyala RS (2000) Penetrating keratoplasty and glaucoma. Surv Ophthalmol 45(2):91–105
Foulks GN (1987) Glaucoma associated with penetrating keratoplasty. Ophthalmology 94(7):871–874
Sekhar GC, Vyas P, Nagarajan R, Mandal AK, Gupta S (1993) Post-penetrating keratoplasty glaucoma. Indian J Ophthalmol 41(4):181–184
Goldberg DB, Schanzlin DJ, Brown SI (1981) Incidence of increased intraocular pressure after keratoplasty. Am J Ophthalmol 92(3):372–377
Polack FM (1988) Glaucoma in keratoplasty. Cornea 7(1):67–70
Wood TO, West C, Kaufman HE (1972) Control of intraocular pressure in penetrating keratoplasty. Am J Ophthalmol 74(4):724–728
Doughty MJ, Zaman ML (2000) Human corneal thickness and its impact on intraocular pressure measures: a review and meta-analysis approach. Surv Ophthalmol 44(5):367–408
Hansen FK (1971) A clinical study of the normal human central corneal thickness. Acta Ophthalmol (Copenh) 49(1):82–9
Hansen FK, Ehlers N (1971) Elevated tonometer readings caused by a thick cornea. Acta Ophthalmol (Copenh) 49(5):775–778
Stodtmeister R (1998) Applanation tonometry and correction according to corneal thickness. Acta Ophthalmol Scand 76(3):319–24
Argus WA (1995) Ocular hypertension and central corneal thickness. Ophthalmology 102(12):1810–1812
Ehlers N, Bramsen T, Sperling S (1975) Applanation tonometry and central corneal thickness. Acta Ophthalmol (Copenh) 53(1):34–43
Graf M (1991) Significance of the corneal thickness in non-contact tonometry. Klin Monatsbl Augenheilkd 199(3):183–186
Johnson M, Kass MA, Moses RA, Grodzki WJ (1978) Increased corneal thickness simulating elevated intraocular pressure. Arch Ophthalmol 96(4):664–665
Herndon LW, Choudhri SA, Cox T, Damji KF, Shields MB, Allingham RR (1997) Central corneal thickness in normal, glaucomatous, and ocular hypertensive eyes. Arch Ophthalmol 115(9):1137–1141
Moses RA (1961) Repeated applanation tonometry. Ophthalmologica 142:663–668
Moses RA (1958) The Goldmann applanation tonometer. Am J Ophthalmol 46(6):865–869
Sudesh S, Moseley MJ, Thompson JR (1993) Accuracy of Goldmann tonometry in clinical practice. Acta Ophthalmol (Copenh) 71(2):185–188
Whitacre MM, Stein R (1993) Sources of error with use of Goldmann-type tonometers. Surv Ophthalmol 38(1):1–30
Kaufman HE (1972) Pressure measurement: which tonometer? Invest Ophthalmol 11(2):80–85
McMillan F, Forster RK (1975) Comparison of MacKay–Marg, Goldmann, and Perkins tonometers in abnormal corneas. Arch Ophthalmol 93(6):420–424
Copt RP, Thomas R, Mermoud A (1999) Corneal thickness in ocular hypertension, primary open-angle glaucoma, and normal tension glaucoma. Arch Ophthalmol 117(1):14–16
Ehlers N, Hansen FK, Aasved H (1975) Biometric correlations of corneal thickness. Acta Ophthalmol (Copenh) 53(4):652–659
Korey M, Gieser D, Kass MA, Waltman SR, Gordon M, Becker B (1982) Central corneal endothelial cell density and central corneal thickness in ocular hypertension and primary open-angle glaucoma. Am J Ophthalmol 94(5):610–616
Wolfs RC, Klaver CC, Vingerling JR, Grobbee DE, Hofman A, de Jong PT (1997) Distribution of central corneal thickness and its association with intraocular pressure: The Rotterdam Study. Am J Ophthalmol 123(6):767–772
Bron AM, Creuzot-Garcher C, Goudeau_Boutillon S, d’Athis P (1999) Falsely elevated intraocular pressure due to increased central corneal thickness. Graefes Arch Clin Exp Ophthalmol 237(3):220–224
Ehlers N, Hansen FK (1974) Central corneal thickness in low-tension glaucoma. Acta Ophthalmol (Copenh) 52(5):740–746
Tomlinson A, Leighton DA (1972) Ocular dimensions in low tension glaucoma compared with open-angle glaucoma and the normal. Br J Ophthalmol 56(2):97–105
Aghaian E, Choe JE, Lin S, Stamper RL (2004) Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic. Ophthalmology 111(12):2211–2219
Kniestedt C, Lin S, Choe J, Nee M, Bostrom A, Sturmer J et al (2006) Correlation between intraocular pressure, central corneal thickness, stage of glaucoma, and demographic patient data: prospective analysis of biophysical parameters in tertiary glaucoma practice populations. J Glaucoma 15(2):91–97
Racette L, Boden C, Kleinhandler SL, Girkin CA, Liebmann JM, Zangwill LM et al (2005) Differences in visual function and optic nerve structure between healthy eyes of blacks and whites. Arch Ophthalmol 123(11):1547–1553
Yo C, Ariyasu RG (2005) Racial differences in central corneal thickness and refraction among refractive surgery candidates. J Refract Surg 21(2):194–197
Hanna CL, Roberts RT, Hwang SJ, Wilhelmus KR (2004) Pachymetry of donor corneas: effect of ethnicity and gender on central corneal thickness. Cornea 23(7):701–703
Herndon LW, Weizer JS, Stinnett SS (2004) Central corneal thickness as a risk factor for advanced glaucoma damage. Arch Ophthalmol 122(1):17–21
Shimmyo M, Ross AJ, Moy A, Mostafavi R (2003) Intraocular pressure, Goldmann applanation tension, corneal thickness, and corneal curvature in Caucasians, Asians, Hispanics, and African Americans. Am J Ophthalmol 136(4):603–613
Brandt JD, Beiser JA, Kass MA, Gordon MO (2001) Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS). Ophthalmology 108(10):1779–1788
La Rosa FA, Gross RL, Orengo-Nania S (2001) Central corneal thickness of Caucasians and African Americans in glaucomatous and nonglaucomatous populations. Arch Ophthalmol 119(1):23–27
Nemesure B, Wu SY, Hennis A, Leske MC, Barbados Eye Study Group (2003) Corneal thickness and intraocular pressure in the Barbados eye studies. Arch Ophthalmol 121(2):240–244
Holladay JT, Allison ME, Prager TC (1983) Goldmann applanation tonometry in patients with regular corneal astigmatism. Am J Ophthalmol 96(1):90–93
Kaufman HE, Wind CA, Waltman SR (1970) Validity of MacKay–Marg electronic applanation tonometer in patients with scarred irregular corneas. Am J Ophthalmol 69(6):1003–1007
Wind CA, Kaufman HE (1971) Validity of MacKay–Marg applanation tonometry following penetrating keratoplasty in man. Am J Ophthalmol 72(1):117–118
Rootman DS, Insler MS, Thompson HW, Parelman J, Poland D, Unterman SR (1988) Accuracy and precision of the Tono-Pen in measuring intraocular pressure after keratoplasty and epikeratophakia and in scarred corneas. Arch Ophthalmol 106(12):1697–1700
Geyer O, Mayron Y, Loewenstein A, Neudorfer M, Rothkoff L, Lazar M (1992) Tono-Pen tonometry in normal and in post-keratoplasty eyes. Br J Ophthalmol 76(9):538–540
Jain AK, Saini JS, Gupta R (2000) Tonometry in normal and scarred corneas, and in postkeratoplasty eyes: a comparative study of the Goldmann, the ProTon and the Schiotz tonometers. Indian J Ophthalmol 48(1):25–32
Pandav SS, Sharma A, Gupta A, Sharma SK, Gupta A (2002) Reliability of proton and goldmann applanation tonometers in normal and postkeratoplasty eyes. Ophthalmology 109(5):979–984
Browning AC, Bhan A, Rotchford AP, Shah S, Dua HS (2004) The effect of corneal thickness on intraocular pressure measurement in patients with corneal pathology. Br J Ophthalmol 88(11):1395–1399
Lisle C, Ehlers N (2000) A clinical comparison of the Xpert non-contact tonometer with the Goldmann applanation tonometer after penetrating keratoplasty. Acta Ophthalmol Scand 78(2):211–215
Amm M, Hedderich J (2005) Transpalpebral tonometry with a digital tonometer in healthy eyes and after penetrating keratoplasty. Ophthalmologe 102(1):70–76
Irvine AR, Kaufman HE (1969) Intraocular pressure following penetrating keratoplasty. Am J Ophthalmol 68(5):835–844
Aldave AJ, Rudd JC, Cohen EJ, Rapuano CJ, Laibson PR (2000) The role of glaucoma therapy in the need for repeat penetrating keratoplasty. Cornea 19(6):772–776
Price FW Jr, Whitson WE, Johns S, Gonzales JS (1996) Risk factors for corneal graft failure. J Refract Surg 12(1):134–143; discussion 143–147
Price MO, Thompson RW Jr, Price FW Jr (2003) Risk factors for various causes of failure in initial corneal grafts. Arch Ophthalmol 121(8):1087–1092
Malaise-Stals J, Collignon-Brach J, Weekers JF (1984) Corneal endothelial cell density in acute angle-closure glaucoma. Ophthalmologica 189(3):104–109
Setala K (1979) Corneal endothelial cell density after an attack of acute glaucoma. Acta Ophthalmol (Copenh) 57(6):1004–1013
Hong C, Kandori T, Kitazawa Y, Tanishima T (1982) The corneal endothelial cells in ocular hypertension. Jpn J Ophthalmol 26(2):183–189
Vannas A, Setala K, Ruusuvaara P (1977) Endothelial cells in capsular glaucoma. Acta Ophthalmol (Copenh) 55(6):951–958
Wenzel M, Reinhard T, Reim M, Grotepass J (1988) Glaucoma and the endothelium. Fortschr Ophthalmol 85(5):474–477
Sherwood MB, Grierson I, Millar L, Hitchings RA (1989) Long-term morphologic effects of antiglaucoma drugs on the conjunctiva and Tenon’s capsule in glaucomatous patients. Ophthalmology 96(3):327–335
Baudouin C, Pisella PJ, Fillacier K, Goldschild M, Becquet F, De Saint Jean M et al (1999) Ocular surface inflammatory changes induced by topical antiglaucoma drugs: human and animal studies. Ophthalmology 106(3):556–563
Burstein NL (1980) Corneal cytotoxicity of topically applied drugs, vehicles and preservatives. Surv Ophthalmol 25(1):15–30
Baudouin C (1996) Side effects of antiglaucomatous drugs on the ocular surface. Curr Opin Ophthalmol 7(2):80–86
Liu GS, Trope GE, Basu PK (1989) Ultrastructural effects of topical betoptic, betagan, and timoptic on the rabbit corneal endothelium. J Ocul Pharmacol 5(4):329–342
Brubaker RF, Coakes RL, Bourne WM (1979) Effect of timolol on the permeability of corneal endothelium. Ophthalmology 86(1):108–111
Konowal A, Morrison JC, Brown SV, Cooke DL, Maguire LJ, Verdier DV et al (1999) Irreversible corneal decompensation in patients treated with topical dorzolamide. Am J Ophthalmol 127(4):403–406
Domingo Gordo B, Urcelay Segura JL, Conejero Arroyo J, Balado Vazquez P, Rodriguez Austin P (2002) Corneal descompensation in patients with endothelial compromise treated with topical dorzolamide. Arch Soc Esp Oftalmol 77(3):139–144
Ficker LA, Kirkness CM, Steele AD, Rice NS, Gilvarry AM (1990) Intraocular surgery following penetrating keratoplasty: the risks and advantages. Eye 4(Pt 5):693–697
Abbott RL, Forster RK (1979) Clinical specular microscopy and intraocular surgery. Arch Ophthalmol 97(8):1476–1479
Dreyer EB, Chaturvedi N, Zurakowski D (1995) Effect of mitomycin C and fluorouracil-supplemented trabeculectomies on the anterior segment. Arch Ophthalmol 113(5):578–580
Mattox C (1995) Glaucoma filtration surgery and antimetabolites. Ophthalmic Surg Lasers 26(5):473–480
Chen CW, Huang HT, Bair JS, Lee CC (1990) Trabeculectomy with simultaneous topical application of mitomycin-C in refractory glaucoma. J Ocul Pharmacol 6(3):175–182
Nguyen NX, Kuchle M, Martus P, Naumann GO (1999) Quantification of blood–aqueous barrier breakdown after trabeculectomy: pseudoexfoliation versus primary open-angle glaucoma. J Glaucoma 8(1):18–23
McDonnell PJ, Robin JB, Schanzlin DJ, Minckler D, Baerveldt G, Smith RE et al (1988) Molteno implant for control of glaucoma in eyes after penetrating keratoplasty. Ophthalmology 95(3):364–369
Topouzis F, Coleman AL, Choplin N, Bethlem MM, Hill R, Yu F et al (1999) Follow-up of the original cohort with the Ahmed glaucoma valve implant. Am J Ophthalmol 128(2):198–204
Kirkness CM, Ling Y, Rice NS (1988) The use of silicone drainage tubing to control post-keratoplasty glaucoma. Eye 2(Pt 5):583–590
Thoft RA, Gordon JM, Dohlman CH (1974) Glaucoma following keratoplasty. Trans Am Acad Ophthalmol Otolaryngol 78(2):OP352–64
Redbrake C, Arend O (2000) Corneal transplantation and glaucoma. Ophthalmologe 97(8):552–556
Kirkness CM, Moshegov C (1988) Post-keratoplasty glaucoma. Eye 2(Suppl):S19–26
Muenzler WS, Harms WK (1981) Visual prognosis in aphakic bullous keratopathy treated by penetrating keratoplasty: a retrospective study of 73 cases. Ophthalmic Surg 12(3):210–212
Schanzlin DJ, Robin JB, Gomez DS, Gindi JJ, Smith RE (1984) Results of penetrating keratoplasty for aphakic and pseudophakic bullous keratopathy. Am J Ophthalmol 98(3):302–312
Wilson SE, Kaufman HE (1990) Graft failure after penetrating keratoplasty. Surv Ophthalmol 34(5):325–356
Jonas JB, Rank RM, Hayler JK, Budde WM (2001) Intraocular pressure after homologous penetrating keratoplasty. J Glaucoma 10(1):32–37
Seitz B, Langenbucher A, Nguyen NX, Kuchle M, Naumann GO (2002) Long-term follow-up of intraocular pressure after penetrating keratoplasty for keratoconus and Fuchs’ dystrophy: comparison of mechanical and Excimer laser trephination. Cornea 21(4):368–373
Olson RJ, Kaufman HE (1977) A mathematical description of causative factors and prevention of elevated intraocular pressure after keratoplasty. Invest Ophthalmol Vis Sci 16(12):1085–1092
Zimmerman TJ, Krupin T, Grodzki W, Waltman SR (1978) The effect of suture depth on outflow facility in penetrating keratoplasty. Arch Ophthalmol 96(3):505–506
Foulks GN, Perry HD, Dohlman CH (1979) Oversize corneal donor grafts in penetrating keratoplasty. Ophthalmology 86(3):490–494
Olson RJ (1978) Aphakic keratoplasty. Determining donor tissue size to avoid elevated intraocular pressure. Arch Ophthalmol 96(12):2274–2276
Bourne WM, Davison JA, O’Fallon WM (1982) The effects of oversize donor buttons on postoperative intraocular pressure and corneal curvature in aphakic penetrating keratoplasty. Ophthalmology 89(3):242–246
Zimmerman T, Olson R, Waltman S, Kaufman H (1978) Transplant size and elevated intraocular pressure. Postkeratoplasty. Arch Ophthalmol 96(12):2231–2233
Perl T, Charlton KH, Binder PS (1981) Disparate diameter grafting. Astigmatism, intraocular pressure, and visual acuity. Ophthalmology 88(8):774–781
Lindstrom RL, Harris WS, Doughman DJ (1981) Combined penetrating keratoplasty, extracapsular cataract extraction, and posterior chamber lens implantation. J Am Intraocul Implant Soc 7(2):130–132
Tuberville A, Nissenkorn I, Tomoda T, Wood TO (1983) Postsurgical intraocular pressure elevation. J Am Intraocul Implant Soc 9(3):309–312
Olson RJ, Kaufman HE (1978) Prognostic factors of intraocular pressure after aphakic keratoplasty. Am J Ophthalmol 86(4):510–515
Lass JH, Pavan-Langston D (1979) Timolol therapy in secondary angle-closure glaucoma post penetrating keratoplasty. Ophthalmology 86(1):51–59
Cohen EJ, Kenyon KR, Dohlman CH (1982) Iridoplasty for prevention of post-keratoplasty angle closure and glaucoma. Ophthalmic Surg 13(12):994–996
Tripathi RC, Parapuram SK, Tripathi BJ, Zhong Y, Chalam KV (1999) Corticosteroids and glaucoma risk. Drugs Aging 15(6):439–450
Graupner M, Seitz B, Langenbucher A, Martus P, Bluthner K, Nguyen NX et al (2000) Interim results from the prospective “Erlanger Non-high-risk Penetrating Keratoplasty Study” in 207 patients. Klin Monatsbl Augenheilkd 217(3):163–170
Kus MM, Kuchle M, Langenbucher A, Seitz B, Nguyen NX, Bluthner K et al (1998) Design and preliminary results of the Erlanger non-high-risk penetrating-keratoplasty study. Klin Monatsbl Augenheilkd 213(4):207–212
Stewart RH, Kimbrough RL (1979) Intraocular pressure response to topically administered fluorometholone. Arch Ophthalmol 97(11):2139–2140
Stewart R, Horowitz B, Howes J, Novack GD, Hart K (1998) Double-masked, placebo-controlled evaluation of loteprednol etabonate 0.5% for postoperative inflammation. Loteprednol Etabonate Post-operative Inflammation Study Group 1. J Cataract Refract Surg 24(11):1480–1489
Leibowitz HM, Bartlett JD, Rich R, McQuirter H, Stewart R, Assil K (1996) Intraocular pressure-raising potential of 1.0% rimexolone in patients responding to corticosteroids. Arch Ophthalmol 114(8):933–937
Perry HD, Donnefeld ED, Kanellopoulos AJ, Grossman GA (1997) Topical cyclosporin A in the management of postkeratoplasty glaucoma. Cornea 16(3):284–288
Bigar F, Witmer R (1982) Corneal endothelial changes in primary acute angle-closure glaucoma. Ophthalmology 89(6):596–599
Mortensen AC, Sperling S (1982) Human corneal endothelial cell density after an in vitro imitation of elevated intraocular pressure. Acta Ophthalmol (Copenh) 60(3):475–479
Olsen T (1980) The endothelial cell damage in acute glaucoma. On the corneal thickness response to intraocular pressure. Acta Ophthalmol (Copenh) 58(2):257–266
Svedbergh B (1975) Effects of artificial intraocular pressure elevation on the corneal endothelium in the vervet monkey (Cercopithecus ethiops). Acta Ophthalmol (Copenh) 53(6):839–855
Knorr HL, Handel A, Naumann GO (1991) Morphometric and qualitative changes in corneal endothelium in primary chronic open angle glaucoma. Fortschr Ophthalmol 88(2):118–120
Gagnon MM, Boisjoly HM, Brunette I, Charest M, Amyot M (1997) Corneal endothelial cell density in glaucoma. Cornea 16(3):314–318
Ohtsuki M, Yokoi N, Mori K, Matsumoto Y, Adachi W, Ishibashi K et al (2001) Adverse effects of beta-blocker eye drops on the ocular surface. Nippon Ganka Gakkai Zasshi 105(3):149–154
Niiya A, Yokoi N, Matsumoto Y, Komuro A, Ishibashi T, Tomii S et al (2000) Effect of beta-blocker eyedrops on corneal epithelial barrier function. Ophthalmologica 214(5):332–336
Mackool RJ, Muldoon T, Fortier A, Nelson D (1977) Epinephrine-induced cystoid macular edema in aphakic eyes. Arch Ophthalmol 95(5):791–793
West CE, Fitzgerald CR, Sewell JH (1973) Cystoid macular edema following aphakic keratoplasty. Am J Ophthalmol 75(1):77–81
Michels RG, Maumenee AE (1975) Cystoid macular edema associated with topically applied epinephrine in aphakic eyes. Am J Ophthalmol 80((3 Pt 1)):379–388
Mori M, Araie M, Sakurai M, Oshika T (1992) Effects of pilocarpine and tropicamide on blood–aqueous barrier permeability in man. Invest Ophthalmol Vis Sci 33(2):416–423
Fechtner RD, Khouri AS, Zimmerman TJ, Bullock J, Feldman R, Kulkarni P et al (1998) Anterior uveitis associated with latanoprost. Am J Ophthalmol 126(1):37–41
Warwar RE, Bullock JD (1999) Latanoprost-induced uveitis. Surv Ophthalmol 43(5):466–468
Warwar RE, Bullock JD, Ballal D (1998) Cystoid macular edema and anterior uveitis associated with latanoprost use. Experience and incidence in a retrospective review of 94 patients. Ophthalmology 105(2):263–268
Wand M, Gilbert CM, Liesegang TJ (1999) Latanoprost and herpes simplex keratitis. Am J Ophthalmol 127(5):602–604
Schumer RA, Camras CB, Mandahl AK (2002) Putative side effects of prostaglandin analogs. Surv Ophthalmol 47(Suppl 1):S219
Ekatomatis P (2001) Herpes simplex dendritic keratitis after treatment with latanoprost for primary open angle glaucoma. Br J Ophthalmol 85(8):1008–1009
Morales J, Shihab ZM, Brown SM, Hodges MR (2001) Herpes simplex virus dermatitis in patients using latanoprost. Am J Ophthalmol 132(1):114–116
Dios Castro E, Maquet Dusart JA (2000) Latanoprost-associated recurrent herpes simplex keratitis. Arch Soc Esp Oftalmol 75(11):775–778
Camras CB (2000) Latanoprost increases the severity and recurrence of herpetic keratitis in the rabbit; latanoprost and herpes simplex keratitis. Am J Ophthalmol 129(2):271–272; author reply 272–273
Asensio Sanchez VM (2001) Recurrent corneal keratitis associated with the use of latanoprost. Arch Soc Esp Oftalmol 76(5):277
Fraunfelder FT (1989) Drugs used primarily in ophthalmology. In: Meyer SM (ed) Drug-induced ocular side effects and drug interactions. Lea & Febiger, Philadelphia, pp 476–477
Walker TD (2004) Benzalkonium toxicity. Clin Exp Ophthalmol 32(6):657
Tripathi BJ, Tripathi RC, Kolli SP (1992) Cytotoxicity of ophthalmic preservatives on human corneal epithelium. Lens Eye Toxic Res 9(3–4):361–375
Tripathi BJ, Tripathi RC (1989) Cytotoxic effects of benzalkonium chloride and chlorobutanol on human corneal epithelial cells in vitro. Lens Eye Toxic Res 6(3):395–403
Epstein DL, Grant WM (1977) Carbonic anhydrase inhibitor side effects. Serum chemical analysis. Arch Ophthalmol 95(8):1378–1382
Reyes E, Izquierdo NJ, Blasini M (1997) Adverse drugs reactions associated with glaucoma medications. Bol Asoc Med P R 89(4–6):51–55
Everitt DE, Avorn J (1990) Systemic effects of medications used to treat glaucoma. Ann Intern Med 112(2):120–125
Schwartz AL, Wilson MC, Schwartz LW (1997) Efficacy of argon laser trabeculoplasty in aphakic and pseudophakic eyes. Ophthalmic Surg Lasers 28(3):215–218
Van Meter WS, Allen RC, Waring GO 3rd, Stulting RD (1988) Laser trabeculoplasty for glaucoma in aphakic and pseudophakic eyes after penetrating keratoplasty. Arch Ophthalmol 106(2):185–188
Goldmann DB, Mellin KB (1987) Argon laser trabeculoplasty in special forms of open-angle glaucoma. Klin Monatsbl Augenheilkd 191(1):13–15
Goldberg I (1985) Argon laser trabeculoplasty and the open-angle glaucomas. Aust N Z J Ophthalmol 13(3):243–248
Brooks AM, Gillies WE (1984) Do any factors predict a favourable response to laser trabeculoplasty? Aust J Ophthalmol 12(2):149–153
Horns DJ, Bellows AR, Hutchinson BT, Allen RC (1983) Argon laser trabeculoplasty for open angle glaucoma. A retrospective study of 380 eyes. Trans Ophthalmol Soc U K 103(Pt 3):288–296
Shingleton BJ, Richter CU, Bellows AR, Hutchinson BT, Glynn RJ (1987) Long-term efficacy of argon laser trabeculoplasty. Ophthalmology 94(12):1513–1518
Gilvarry AM, Kirkness CM, Steele AD, Rice NS, Ficker LA (1989) The management of post-keratoplasty glaucoma by trabeculectomy. Eye 3(Pt 6):713–718
Insler MS, Cooper HD, Kastl PR, Caldwell DR (1985) Penetrating keratoplasty with trabeculectomy. Am J Ophthalmol 100(4):593–595
Fluorouracil Filtering Surgery Study one-year follow-up. The Fluorouracil Filtering Surgery Study Group (1989) Am J Ophthalmol 108(6):625–635
Joos KM, Bueche MJ, Palmberg PF, Feuer WJ, Grajewski AL (1995) One-year follow-up results of combined mitomycin C trabeculectomy and extracapsular cataract extraction. Ophthalmology 102(1):76–83
Skuta GL, Beeson CC, Higginbotham EJ, Lichter PR, Musch DC, Bergstrom TJ et al (1992) Intraoperative mitomycin versus postoperative 5-fluorouracil in high-risk glaucoma filtering surgery. Ophthalmology 99(3):438–444
Ayyala RS, Pieroth L, Vinals AF, Goldstein MH, Schuman JS, Netland PA et al (1998) Comparison of mitomycin C trabeculectomy, glaucoma drainage device implantation, and laser neodymium:YAG cyclophotocoagulation in the management of intractable glaucoma after penetrating keratoplasty. Ophthalmology 105(8):1550–1556
Figueiredo RS, Araujo SV, Cohen EJ, Rapuano CJ, Katz LJ, Wilson RP (1996) Management of coexisting corneal disease and glaucoma by combined penetrating keratoplasty and trabeculectomy with mitomycin-C. Ophthalmic Surg Lasers 27(11):903–909
Chowers I, Ticho U (1999) Mitomycin-C in combined or two-stage procedure trabeculectomy followed by penetrating keratoplasty. J Glaucoma 8(3):184–187
WuDunn D, Alfonso E, Palmberg PF (1999) Combined penetrating keratoplasty and trabeculectomy with mitomycin C. Ophthalmology 106(2):396–400
Ishioka M, Shimazaki J, Yamagami J, Fujishima H, Shimmura S, Tsubota K (2000) Trabeculectomy with mitomycin C for post-keratoplasty glaucoma. Br J Ophthalmol 84(7):714–717
Beebe WE, Starita RJ, Fellman RL, Lynn JR, Gelender H (1990) The use of Molteno implant and anterior chamber tube shunt to encircling band for the treatment of glaucoma in keratoplasty patients. Ophthalmology 97(11):1414–1422
Cohen EJ, Schwartz LW, Luskind RD, Parker AV, Spaeth GL, Katz LJ et al (1989) Neodymium: YAG laser transscleral cyclophotocoagulation for glaucoma after penetrating keratoplasty. Ophthalmic Surg 20(10):713–716
Rapuano CJ, Schmidt CM, Cohen EJ, Rajpal RK, Raber IM, Katz LJ et al (1995) Results of alloplastic tube shunt procedures before, during, or after penetrating keratoplasty. Cornea 14(1):26–32
Threlkeld AB, Shields MB (1995) Noncontact transscleral Nd:YAG cyclophotocoagulation for glaucoma after penetrating keratoplasty. Am J Ophthalmol 120(5):569–576
Wheatcroft S, Singh A, Casey T, McAllister J (1992) Treatment of glaucoma following penetrating keratoplasty with transscleral YAG cyclophotocoagulation. Int Ophthalmol 16(4–5):397–400
Zalloum JN, Ahuja RM, Shin D, Weiss JS (1999) Assessment of corneal decompensation in eyes having undergone molteno shunt procedures compared to eyes having undergone trabeculectomy. CLAO J 25(1):57–60
Kirkness CM (1987) Penetrating keratoplasty, glaucoma and silicone drainage tubing. Dev Ophthalmol 14:161–165
Sherwood MB, Smith MF, Driebe WT Jr, Stern GA, Beneke JA, Zam ZS (1993) Drainage tube implants in the treatment of glaucoma following penetrating keratoplasty. Ophthalmic Surg 24(3):185–189
Kwon YH, Taylor JM, Hong S, Honkanen RA, Zimmerman MB, Alward WL et al (2001) Long-term results of eyes with penetrating keratoplasty and glaucoma drainage tube implant. Ophthalmology 108(2):272–278
Lim KS (2003) Corneal endothelial cell damage from glaucoma drainage device materials. Cornea 22(4):352–354
Alvarenga LS, Mannis MJ, Brandt JD, Lee WB, Schwab IR, Lim MC (2004) The long-term results of keratoplasty in eyes with a glaucoma drainage device. Am J Ophthalmol 138(2):200–205
Assaad MH, Baerveldt G, Rockwood EJ (1999) Glaucoma drainage devices: pros and cons. Curr Opin Ophthalmol 10(2):147–153
Al-Torbak A (2003) Graft survival and glaucoma outcome after simultaneous penetrating keratoplasty and ahmed glaucoma valve implant. Cornea 22(3):194–197
Arroyave CP, Scott IU, Fantes FE, Feuer WJ, Murray TG (2001) Corneal graft survival and intraocular pressure control after penetrating keratoplasty and glaucoma drainage device implantation. Ophthalmology 108(11):1978–1985
Hodkin MJ, Goldblatt WS, Burgoyne CF, Ball SF, Insler MS (1995) Early clinical experience with the Baerveldt implant in complicated glaucomas. Am J Ophthalmol 120(1):32–40
Coleman AL, Mondino BJ, Wilson MR, Casey R (1997) Clinical experience with the Ahmed Glaucoma Valve implant in eyes with prior or concurrent penetrating keratoplasties. Am J Ophthalmol 123(1):54–61
Johnston RH, Nguyen R, Jongsareejit A, Lee BR, Patel S, Chong LP (1999) Clinical study of combined penetrating keratoplasty, pars plana vitrectomy with temporary keratoprosthesis, and pars plana seton implant. Retina 19(2):116–121
Sidoti PA, Mosny AY, Ritterband DC, Seedor JA (2001) Pars plana tube insertion of glaucoma drainage implants and penetrating keratoplasty in patients with coexisting glaucoma and corneal disease. Ophthalmology 108(6):1050–1058
Binder PS, Abel R Jr, Kaufman HE (1975) Cyclocryotherapy for glaucoma after penetrating keratoplasty. Am J Ophthalmol 79(3):489–492
West CE, Wood TO, Kaufman HE (1973) Cyclocryotherapy for glaucoma pre- or postpenetrating keratoplasty. Am J Ophthalmol 76(4):485–489
Hardten DR, Brown JD, Holland EJ (1993) Results of Neodymium: YAG laser transscleral cyclophotocoagulation for postkeratoplasty glaucoma. J Glaucoma 2:241–245
Levy NS, Bonney RC (1989) Transscleral YAG cyclocoagulation of the ciliary body for persistently high intraocular pressure following penetrating keratoplasty. Cornea 8(3):178–181
Beiran I, Rootman DS, Trope GE, Buys YM (2000) Long-term results of transscleral Nd:YAG cyclophotocoagulation for refractory glaucoma postpenetrating keratoplasty. J Glaucoma 9(3):268–272
Ocakoglu O, Arslan OS, Kayiran A (2005) Diode laser transscleral cyclophotocoagulation for the treatment of refractory glaucoma after penetrating keratoplasty. Curr Eye Res 30(7):569–574
Shah P, Lee GA, Kirwan JK, Bunce C, Bloom PA, Ficker LA et al (2001) Cyclodiode photocoagulation for refractory glaucoma after penetrating keratoplasty. Ophthalmology 108(11):1986–1991
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Greenlee, E.C., Kwon, Y.H. Graft failure: III. Glaucoma escalation after penetrating keratoplasty. Int Ophthalmol 28, 191–207 (2008). https://doi.org/10.1007/s10792-008-9223-5
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DOI: https://doi.org/10.1007/s10792-008-9223-5