Abstract
Background In pseudotumor cerebri (PTC), elevated intracranial pressure (ICP) results in papilledema and, rarely, choroidal neovascularization (CNV). Pseudotumor cerebri-induced CNV often regresses following medical or surgical ICP reduction, but additional treatments, such as photocoagulation, photodynamic therapy, peri-ocular steroid injections and/or subretinal surgery, may be necessary. Anti-angiogenic intravitreal injections have been shown to cause regression of both CNV and optic nerve edema. Case report We describe a patient with PTC and CNV whose CNV regressed and vision normalized after a single intravitreal injection of bevacizumab (Avastin; Genentech, San Francisco, CA).
This is a preview of subscription content, log in via an institution to check access.
References
Durcan FJ, Corbett JJ, Wall M (1988) The incidence of pseudotumor cerebri. Population studies in Iowa and Louisiana. Arch Neurol 45:875–877
Wendel L, Lee AG, Boldt HC et al. (2006) Subretinal neovascular membrane in idiopathic intracranial hypertension. Am J Opthalmol 141:573–574
Castellarin AA, Sugino IK, Nasir M et al. (1997) Clinicopathological correlation of an excised choroidal neovascular membrane in pseudotumour cerebri. Br J Ophthalmol 81:994–1000
Avery RL, Pieramici DJ, Rabena MD et al. (2006) Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmology 113:363–372
Finger PT (2007) Anti-VEGF bevacizumab (Avastin) for radiation optic neuropathy. Am J Ophthalmol 143:335–338
Morse PH, Leville AS, Antel JP et al (1981) Bilateral juxtapapillary subretinal neovascularization associated with pseudotumor cerebri. Am J Ophthalmol 91:312–317
Jamison RR (1978) Subretinal neovascularization and papilledema associated with pseudotumor cerebri. Am J Ophthalmol 85:78–81
Sathornsumetee B, Webb A, Hill DH et al. (2006) Subretinal hemorrhage from a peripapillary choroidal neovascular membrane in papilledema caused by idiopathic intracranial hypertension. J Neuroophthalmol 26:197–199
Akova YA, Kansu T, Yazar Z et al. (1994) Macular subretinal neovascular membrane associated with pseudotumor cerebri. J Neuroophthalmol 14:193–195
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jamerson, S.C., Arunagiri, G., Ellis, B.D. et al. Intravitreal bevacizumab for the treatment of choroidal neovascularization secondary to pseudotumor cerebri. Int Ophthalmol 29, 183–185 (2009). https://doi.org/10.1007/s10792-007-9186-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10792-007-9186-y