Skip to main content

Advertisement

Log in

Periorbital necrobiosis lipoidica diabeticorum: case report

  • Case Report
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Necrobiosis lipoidica diabeticorum (NLD) is a relatively common manifestation of diabetes mellitus that is thought to be related to immune-complex vasculitis. The legs are the most common site for NLD, but other locations, such as the forearms or hands, have been reported. We describe a case of periorbital NLD that was diagnosed on the basis of histopathology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

References

  1. Quimby SR, Muller SA, Schroeter AL (1988) The cutaneous immunopathology of necrobiosis lipoidica diabeticorum. Arch Dermatol 124:1364–1371

    Article  PubMed  CAS  Google Scholar 

  2. Imakado S, Satomi H, Iskikawa M, Iwata M et al (1998) Diffuse necrobiosis lipoidica diabeticorum associated with non-insulin dependent diabetes mellitus. Clin Exp Dermatol 23(6):271–272

    Article  PubMed  CAS  Google Scholar 

  3. Gaethe G (1964) Necrobiosis lipoidica diabeticorum of the scalp. Arch Dermatol 89:865–866

    Article  PubMed  CAS  Google Scholar 

  4. Mackey JP (1975) Necrobiosis lipoidica diabeticorum involving scalp and face. Br J Dermatol 93(6):729–730

    Article  PubMed  CAS  Google Scholar 

  5. Macaron NC, Cohen C, Chen SC, Arbiser JL (2005) gli-1 oncogene is highly expressed in granulomatous skin disorders, including sarcoidosis, granuloma annulare, and necrobiosis lipoidica diabeticorum. Arch Dermatol 141:259–262

    Article  PubMed  CAS  Google Scholar 

  6. McNutt NS, Smoller BR, Contreras F (1996) Skin. In: Damjanov I, Linder J (eds) Anderson’s pathology. Mosby, St. Louis, pp 2389–2479

    Google Scholar 

  7. Shapiro PE (1997): Noninfectious granulomas. In: Elder D (ed) Lever’s histopathology of the skin. Lippincott-Raven, Philadelphia, 317–340

    Google Scholar 

  8. Burnstine MA, Headington JT, Reifler DM, Oestreicher JH, Elner VM (1994) Periocular granuloma annulare, nodular type; occurence in late middle age. Arch Ophthalmol 112:1590–1593

    PubMed  CAS  Google Scholar 

  9. Alegre VA, Winkelmann RK (1998) A new histopathologic feature of the necrobiosis lipoidica diabeticorum: Lymphoid nodules. J Cutan Pathol 15:75

    Article  Google Scholar 

  10. Mehregan AH, Pinkus H (1961) Necrobiosis lipoidica with sarcoid reaction. Arch Dermatol 83:143

    PubMed  CAS  Google Scholar 

  11. Remes K, Rönnemaa T (1999) Healing of chronic leg ulcers in diabetic necrobiosis lipoidica with local granulocyte-macrophage colony-stimulating factor treatment. J. Diabetes Complicat 13:115–118

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Selcuk Sizmaz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sizmaz, S., Pelit, A., Bolat, F. et al. Periorbital necrobiosis lipoidica diabeticorum: case report. Int Ophthalmol 28, 307–309 (2008). https://doi.org/10.1007/s10792-007-9133-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-007-9133-y

Keywords

Navigation