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Garcinol Suppresses IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via Inhibition of the NF-κB Signaling Pathway

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Abstract

Osteoarthritis (OA), which is characterized as a common degenerative joint disease, is presently the most prevalent chronic degenerative joint disease. Accumulating evidence has shown a biological function for Garcinol in a variety of diseases; however, whether it could be used to treat OA remains unclear. In this study, we explored the protective effects of garcinol on the progression of OA and explored the underlying mechanism. In vitro, garcinol reduced the expression of pro-inflammatory cytokines, such as IL-6 and tumor necrosis factor alpha (TNF-α). It also decreased the expression of inducible nitric oxide synthase (iNOS), as well as cyclooxygenase-2 (COX-2). Furthermore, garcinol inhibited the expression of thrombospondin motifs 5(ADAMTS5) and metalloproteinase (MMPs), both of which regulate extracellular matrix degradation. These changes could be attributed to garcinol-related suppression of the IL-1β-induced NF-κB signaling pathway. Moreover, we investigated the protective effects of garcinol on the surgical destabilization of the medial meniscus (DMM) of the mouse, an in vivo model of OA. Taken together, our data suggest garcinol as a potential future agent for the treatment of OA.

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  • 15 June 2020

    The original version of this article contained mistakes, and the authors would like to correct them.

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Funding

This study was funded by the National Natural Science Foundation of China (grant nos. 81572126 and 81871801) and the Natural Science Foundation of Zhejiang Province (grant nos. LY15H060005 and LQ16H160013).

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Authors and Affiliations

  1. Department of Orthopaedics, Shaoxing People’s Hospital, Zhejiang University School of Medicine, Shaoxing, 312000, Zhejiang, China

    Yewei Jia, Kangxian Zhao, Jiawei Jiang, Tan Zhang, Peng Sun & Yu Qian

  2. Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

    Yewei Jia & Jiawei Jiang

  3. The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China

    Cong Pang, Kangxian Zhao, Tan Zhang & Peng Sun

  4. Guangxi Key Laboratory of Regenerative Medicine, Guangxi Medical University, Guangxi, 530021, China

    Jiaxuan Peng

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  1. Yewei Jia
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  2. Cong Pang
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  3. Kangxian Zhao
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Jia, Y., Pang, C., Zhao, K. et al. Garcinol Suppresses IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via Inhibition of the NF-κB Signaling Pathway. Inflammation 42, 1754–1766 (2019). https://doi.org/10.1007/s10753-019-01037-7

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