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Lapatinib Ameliorates Experimental Arthritis in Rats

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Abstract

Epidermal growth factor receptor (EGFR) and its ligands are commonly expressed by synovial cells. The aim of the present study was to detect the potential effect of lapatinib an inhibitor of EGFR tyrosine kinases on collagen-induced arthritis. Thirty Wistar albino female rats were randomized into three groups. Arthritis was induced by intradermal injection of chicken type II collagen with incomplete Freund’s adjuvant. Serum TNF-α, IL-17, and malondialdehyde (MDA) levels were analyzed. Tissue superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) activities, and nuclear factor erythroid 2-related factor-2 (Nrf2) and heme oxgenase-1 (HO-1) expressions were determined. TNF-α, IL-17 and MDA levels, and Nrf2 and HO-1 expressions were lower in lapatinib-treated (30 mg/kg/day) group compared to sham group, while SOD, catalase, and GPx activities were higher (p < 0.05). Moreover, lapatinib ameliorated perisynovial inflammation and cartilage–bone destruction (p < 0.001). In conclusion, EGFR may have prominent pathogenic role and lapatinib may be an effective therapeutic option for arthritis.

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Approval was obtained from the Ethics Committee of Firat University.

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Authors and Affiliations

  1. Department of Rheumatology, Faculty of Medicine, 19 Mayis University, Samsun, Turkey

    Metin Ozgen

  2. Department of Rheumatology, Faculty of Medicine, Firat University, Elazig, Turkey

    Suleyman Serdar Koca, Ahmet Karatas, Baris Gundogdu & Ahmet Isik

  3. Department of Pathology, Faculty of Medicine, Firat University, Elazig, Turkey

    Adile Ferda Dagli

  4. School of Health Sciences, Firat University, Elazig, Turkey

    Fazilet Erman

  5. Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, Turkey

    Kazim Sahin

  6. Firat Universitesi, Tip Fakultesi, Romatoloji BD., 23119, Elazig, Turkey

    Suleyman Serdar Koca

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  1. Metin Ozgen
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Correspondence to Suleyman Serdar Koca.

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Ozgen, M., Koca, S.S., Karatas, A. et al. Lapatinib Ameliorates Experimental Arthritis in Rats. Inflammation 38, 252–259 (2015). https://doi.org/10.1007/s10753-014-0028-6

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  • DOI: https://doi.org/10.1007/s10753-014-0028-6

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