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Soluble Urokinase Plasminogen Activator Receptor (suPAR) is Associated with Metabolic Changes in HIV-1-Infected Africans: A Prospective Study

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Abstract

Soluble urokinase plasminogen activator receptor (suPAR) is associated with inflammation and may predict lipodystrophy and dysmetabolism in human immunodeficiency virus (HIV)-infected individuals on antiretroviral therapy. We aimed to assess firstly, whether suPAR levels are elevated in treated and untreated HIV-1-infected Africans compared to uninfected controls at baseline and at a 3-year follow-up, and secondly whether suPAR levels are correlated with cardiovascular and/or metabolic changes. SuPAR, cardiovascular, and metabolic variables were assessed and the percentage change was determined. HIV-1-infected black South Africans had significantly higher suPAR levels than uninfected controls at baseline and at follow-up 3 years later. However, only the treated HIV-1-infected participants showed an increase in suPAR levels at follow-up. The treated group also showed signs of lipodystrophy and their baseline suPAR levels correlated positively with an increased waist circumference. This study indicates that suPAR levels increase and that baseline suPAR is associated with an increase in abdominal fat distribution in HIV-infected black Africans on antiretroviral therapy.

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ACKNOWLEDGMENTS

We thank the PURE-SA research team, the field workers and office staff in the Africa Unit for Transdisciplinary Health Research (AUTHeR), North-West University, South Africa, as well as Dr. S. Yusuf (PURE-International) and the PURE project staff at the PHRI, Hamilton Health Sciences and McMaster University, ON, Canada. This work was financially supported by SANPAD (South Africa - Netherlands Research Programme on Alternatives in Development), South African National Research Foundation (NRF GUN numbers 2069139 and FA2006040700010), North-West University, Population Health Research Institute (PHRI), and the Medical Research Council (MRC) of South Africa.

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This manuscript has not been published and is not being considered for publication elsewhere. There are no conflicts of interest.

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Authors and Affiliations

  1. Hypertension in Africa Research Team (HART), School for Physiology, Nutrition and Consumer Sciences, North-West University (Potchefstroom Campus), Private Bag X6001, Potchefstroom, 2520, South Africa

    Carla M. T. Fourie, Johannes M. Van Rooyen, Rudolph Schutte & Aletta E. Schutte

  2. Africa Unit for Transdisciplinary Health Research (AUTHeR), Faculty of Health Science, North-West University, Potchefstroom, 2520, South Africa

    Annamarie Kruger

  3. Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark

    Michael H. Olsen

  4. Clinical Research Centre, Copenhagen University, Hvidovre Hospital, Copenhagen, Denmark

    Jesper Eugen-Olsen

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  1. Carla M. T. Fourie
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  2. Johannes M. Van Rooyen
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  3. Annamarie Kruger
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  4. Michael H. Olsen
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Correspondence to Carla M. T. Fourie.

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Fourie, C.M.T., Van Rooyen, J.M., Kruger, A. et al. Soluble Urokinase Plasminogen Activator Receptor (suPAR) is Associated with Metabolic Changes in HIV-1-Infected Africans: A Prospective Study. Inflammation 35, 221–229 (2012). https://doi.org/10.1007/s10753-011-9308-6

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