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Effect of Unfiltered Coffee on Carbon Tetrachloride-Induced Liver Injury in Rats

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Abstract

To assess the role of unfiltered coffee upon carbon tetrachloride (CCl4) induced hepatotoxicity in rats. All rats were randomly divided into control group, CCl4-treated, unfiltered coffee-treated and CCl4/unfiltered coffee-treated. Hepatic damage was induced by repeated intraperitoneal injections of CCl4 every other day. Unfiltered coffee was given as drinking fluid for 8 days starting the day before CCl4 administration. Liver enzymes, plasma and liver tissue malondialdehyde were analyzed. Histopathological evaluation of liver sections was performed. Serum aminotransferase level significantly increased in CCl4/unfiltered coffee-treated group compared to CCl4-treated group, as well as, lipid peroxidation products in the plasma and liver tissue. In addition, histopathological findings including inflammation and necrosis were significantly confirmed these findings. Unfiltered coffee potentiates acute liver injury in rats with CCl4-induced hepatotoxicity.

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Authors and Affiliations

  1. Division of Gastroenterology, School of Medicine, Firat University, Elazig, Turkey

    Orhan Kursat Poyrazoglu, Ibrahim Halil Bahcecioglu, Huseyin Ataseven & Mehmet Yalniz

  2. Department of Biochemistry, School of Medicine, Firat University, Elazig, Turkey

    Kerem Metin & Bilal Ustundag

  3. Department of Pathology, School of Medicine, Firat University, Elazig, Turkey

    Adile Ferda Dagli

  4. Firat Universitesi, Tip Fakultesi, Ic Hastaliklari AD, Gastroenteroloji BD, 23119, Elazig, Turkey

    Orhan Kursat Poyrazoglu

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  1. Orhan Kursat Poyrazoglu
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  2. Ibrahim Halil Bahcecioglu
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Correspondence to Orhan Kursat Poyrazoglu.

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Poyrazoglu, O.K., Bahcecioglu, I.H., Ataseven, H. et al. Effect of Unfiltered Coffee on Carbon Tetrachloride-Induced Liver Injury in Rats. Inflammation 31, 408–413 (2008). https://doi.org/10.1007/s10753-008-9092-0

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  • DOI: https://doi.org/10.1007/s10753-008-9092-0

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