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Immunoregulation and antioxidant activities of a novel acidic polysaccharide from Radix Paeoniae Alba

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Abstract

Radix Paeoniae Alba is widely used in Chinese traditional medicine to treat various diseases such as gastrointestinal disorders, immunomodulatory, cancer, and other diseases. In this paper, a novel acidic polysaccharide RPAPS purified from Radix Paeoniae Alba was evaluated for its structural features and potential of immunomodulatory and antioxidant activities. RPAPS (molecular weight: 1.0× 105 Da) was mainly composed of α-(1 → 4)-Glcp, α-Arap, α-Galp, α-Rhap, β-D-Glcp, α-(1 → 6)-linked Glcp and GalA. Immunological tests indicated that RPAPS could improve RAW264.7 phagocytic activity and LPS-induced splenocyte proliferation. For antioxidant activities, RPAPS showed reducing power and DPPH scavenging activity in dose dependent. Moreover, RPAPS could significantly protect the PC12 cells from H2O2 damage. These data implied polysaccharides RPAPS had the potential to be novel natural antioxidative and immunopotentiating agents for using in functional foods or medicine.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No.31800678, No.81703945), Science and Technology Innovation Fund of Shanxi Agricultural University (No.2017YJ40, No.2016YJ17), and Science and Technology Innovation Project of Colleges and Universities in Shanxi Province (No.2019 L0365, No.2019 L0360).

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Authors and Affiliations

  1. College of arts and sciences, Shanxi Agricultural University, Taigu, 030801, Shanxi, China

    Wuxia Zhang, Yihua Hu, Jinzhong Zhao, Yongpo Zhang, Dongdong Guo, Chunyan Gao & Peng Li

  2. College of chemistry and pharmacy, Northwest Agricultural and Forestry University, Yangling, 712100, Shaanxi, China

    Jinyou Duan

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  1. Wuxia Zhang
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  2. Yihua Hu
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  3. Jinzhong Zhao
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Zhang, W., Hu, Y., Zhao, J. et al. Immunoregulation and antioxidant activities of a novel acidic polysaccharide from Radix Paeoniae Alba. Glycoconj J 37, 361–371 (2020). https://doi.org/10.1007/s10719-020-09916-0

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