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Mechanistic insight into the adjuvant effect of co-exposure to ultrafine carbon black and high humidity on allergic asthma

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Abstract

Respiratory diseases continue to be a major global concern, with allergies and asthma often discussed as critical areas of study. While the role of environmental risk factors, such as non-allergenic pollutants and high humidity, in asthma induction is often mentioned, there is still a lack of thorough research on their co-exposure. This study aims to investigate the adjuvant effect of ultrafine carbon black (30–50 nm) and high humidity (70% relative humidity) on the induction of allergic asthma. A mouse model of asthma was established using ovalbumin, and airway hyperresponsiveness, remodeling, and inflammation were measured as the endpoint effects of asthma. The mediating role of the oxidative stress pathway and the transient receptor potential vanilloid 1 pathway in asthma induction was validated using pathway inhibitors vitamin E and capsaicin, respectively. Co-exposure to ultrafine carbon black and high humidity had a significant impact on metabolic pathways in the lung, including aminoacyl-tRNA biosynthesis, glycerophospholipid metabolism, and ATP-binding cassette transporters. However, administering vitamin E and capsaicin altered the effects of co-exposure on the lung metabolome. These results offer new insights into the health risk assessment of co-exposure to environmental risk factors and provide an important reference point for the prevention and treatment of allergic asthma.

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References

  • Akdis, M., Aab, A., Altunbulakli, C., Azkur, K., Costa, R. A., Crameri, R., Duan, S., Eiwegger, T., Eljaszewicz, A., Ferstl, R., Frei, R., Garbani, M., Globinska, A., Hess, L., Huitema, C., Kubo, T., Komlosi, Z., Konieczna, P., Kovacs, N., … Akdis, C. A. (2016). Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases. Journal of Allergy and Clinical Immunology, 138(4), 984–1010. https://doi.org/10.1016/j.jaci.2016.06.033

    Article  CAS  Google Scholar 

  • Ali, M. U., Lin, S., Yousaf, B., Abbas, Q., Munir, M. A. M., Rashid, A., Zheng, C., Kuang, X., & Wong, M. H. (2022). Pollution characteristics, mechanism of toxicity and health effects of the ultrafine particles in the indoor environment: Current status and future perspectives. Critical Reviews in Environmental Science and Technology, 52(3), 436–473. https://doi.org/10.1080/10643389.2020.1831359

    Article  CAS  Google Scholar 

  • Aumiller, V., Balsara, N., Wilhelm, J., Guenther, A., & Koenigshoff, M. (2013). WNT/beta-catenin signaling induces IL-1 beta expression by alveolar epithelial cells in pulmonary fibrosis. American Journal of Respiratory Cell and Molecular Biology, 49(1), 96–104. https://doi.org/10.1165/rcmb.2012-0524OC

    Article  CAS  Google Scholar 

  • Barreto, E., Serra, M. F., dos Santos, R. V., Alves dos Santos, C. E., Hickmann, J., Cotias, A. C., Rodrigues Pao, C. R., Trindade, S. G., Schimidt, V., Giacomelli, C., Carvalho, V. F., Rodrigues e Silva, P. M., Balao Cordeiro, R. S., & Martins, M. A. (2015). Local administration of gold nanoparticles prevents pivotal pathological changes in murine models of atopic asthma. Journal of Biomedical Nanotechnology, 11(6), 1038–1050. https://doi.org/10.1166/jbn.2015.2024

    Article  CAS  Google Scholar 

  • Chamitava, L., Cazzoletti, L., Ferrari, M., Garcia-Larsen, V., Jalil, A., Degan, P., Fois, A. G., Zinellu, E., Fois, S. S., Pasini, A. M. F., Nicolis, M., Olivieri, M., Corsico, A., Bono, R., Pirina, P., & Zanolin, M. E. (2020). Biomarkers of oxidative stress and inflammation in chronic airway diseases. International Journal of Molecular Sciences, 21(12), 4339. https://doi.org/10.3390/ijms21124339

    Article  CAS  Google Scholar 

  • Cherrie, M. P. C., Sarran, C., & Osborne, N. J. (2021). Climatic factors are associated with asthma prevalence: An ecological study using English quality outcomes framework general practitioner practice data. Science of the Total Environment, 779, 146478. https://doi.org/10.1016/j.scitotenv.2021.146478

    Article  CAS  Google Scholar 

  • Cook, D. N. (2020). Role of environmental adjuvants in asthma development. Current Allergy and Asthma Reports, 20(9), 42. https://doi.org/10.1007/s11882-020-00935-3

    Article  CAS  Google Scholar 

  • Cook, Q., Argenio, K., & Lovinsky-Desir, S. (2021). The impact of environmental injustice and social determinants of health on the role of air pollution in asthma and allergic disease in the United States. Journal of Allergy and Clinical Immunology, 148(5), 1089–1101. https://doi.org/10.1016/j.jaci.2021.09.018

    Article  CAS  Google Scholar 

  • Cui, H., Huang, J., Lu, M., Zhang, Q., Qin, W., Zhao, Y., Lu, X., Zhang, J., Xi, Z., & Li, R. (2019). Antagonistic effect of vitamin E on nAl(2)O(3)-induced exacerbation of Th2 and Th17-mediated allergic asthma via oxidative stress. Environmental Pollution, 252, 1519–1531. https://doi.org/10.1016/j.envpol.2019.06.092

    Article  CAS  Google Scholar 

  • Deng, L., Ma, P., Wu, Y., Ma, Y., Yang, X., Li, Y., & Deng, Q. (2020a). High and low temperatures aggravate airway inflammation of asthma: Evidence in a mouse model. Environmental Pollution, 256, 113433. https://doi.org/10.1016/j.envpol.2019.113433

    Article  CAS  Google Scholar 

  • Deng, R., Gao, X., Hou, J., & Lin, D. (2020b). Multi-omics analyses reveal molecular mechanisms for the antagonistic toxicity of carbon nanotubes and ciprofloxacin to Escherichia coli. Science of the Total Environment, 726, 138288. https://doi.org/10.1016/j.scitotenv.2020.138288

    Article  CAS  Google Scholar 

  • Deng, R., Lin, D., Zhu, L., Majumdar, S., White, J. C., Gardea-Torresdey, J. L., & Xing, B. (2017). Nanoparticle interactions with co-existing contaminants: Joint toxicity, bioaccumulation and risk. Nanotoxicology, 11(5), 591–612. https://doi.org/10.1080/17435390.2017.1343404

    Article  CAS  Google Scholar 

  • Deng, R., Ma, P., Li, B., Wu, Y., & Yang, X. (2022). Development of allergic asthma and changes of intestinal microbiota in mice under high humidity and/or carbon black nanoparticles. Ecotoxicology and Environmental Safety, 241, 113786. https://doi.org/10.1016/j.ecoenv.2022.113786

    Article  CAS  Google Scholar 

  • Deng, R., Yang, K., & Lin, D. (2021). Pentachlorophenol and ciprofloxacin present dissimilar joint toxicities with carbon nanotubes to Bacillus subtilis. Environmental Pollution. https://doi.org/10.1016/j.envpol.2020.116071

    Article  Google Scholar 

  • Deng, R., Zhu, Y., Hou, J., White, J. C., Gardea-Torresdey, J. L., & Lin, D. (2019). Antagonistic toxicity of carbon nanotubes and pentachlorophenol to Escherichia coli: Physiological and transcriptional responses. Carbon, 145, 658–667. https://doi.org/10.1016/j.carbon.2019.01.077

    Article  CAS  Google Scholar 

  • Deng, R., Zhu, Y., Wu, X. Y., & Wang, M. P. (2023). Toxicity and mechanisms of engineered nanoparticles in animals with established allergic asthma. International Journal of Nanomedicine, 18, 3489–3508. https://doi.org/10.2147/IJN.S411804

    Article  CAS  Google Scholar 

  • Du, C., Zhang, Q., Wang, L., Wang, M., Li, J., & Zhao, Q. (2021). Effect of montelukast sodium and graphene oxide nanomaterials on mouse asthma model. Journal of Nanoscience and Nanotechnology, 21(2), 1161–1168. https://doi.org/10.1166/jnn.2021.18705

    Article  CAS  Google Scholar 

  • Duan, J., Wang, X., Zhao, D., Wang, S., Bai, L., Cheng, Q., Gao, J., Xu, Z., Zhang, Y., Zhang, H., & Su, H. (2019). Risk effects of high and low relative humidity on allergic rhinitis: Time series study. Environmental Research, 173, 373–378. https://doi.org/10.1016/j.envres.2019.03.040

    Article  CAS  Google Scholar 

  • Duan, J., Xie, J., Deng, T., Xie, X., Liu, H., Li, B., & Chen, M. (2020). Exposure to both formaldehyde and high relative humidity exacerbates allergic asthma by activating the TRPV4-p38 MAPK pathway in Balb/c mice. Environmental Pollution, 256, 113375. https://doi.org/10.1016/j.envpol.2019.113375

    Article  CAS  Google Scholar 

  • Fitzpatrick, A. M., Jones, D. P., & Brown, L. A. S. (2012). Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities. Antioxidants and Redox Signaling, 17(2), 375–408. https://doi.org/10.1089/ars.2011.4198

    Article  CAS  Google Scholar 

  • Guijas, C., Montenegro-Burke, J. R., Warth, B., Spilker, M. E., & Siuzdak, G. (2018). Metabolomics activity screening for identifying metabolites that modulate phenotype. Nature Biotechnology, 36(4), 316–320. https://doi.org/10.1038/nbt.4101

    Article  CAS  Google Scholar 

  • Harter, H. (1960). Critical values for Duncan new multiple range test. Biometrics, 16(4), 671–685. https://doi.org/10.2307/2527770

    Article  Google Scholar 

  • Ho, W. E., Xu, Y.-J., Xu, F., Cheng, C., Peh, H. Y., Tannenbaum, S. R., Wong, W. S. F., & Ong, C. N. (2013). Metabolomics reveals altered metabolic pathways in experimental asthma. American Journal of Respiratory Cell and Molecular Biology, 48(2), 204–211. https://doi.org/10.1165/rcmb.2012-0246OC

    Article  CAS  Google Scholar 

  • Ihrie, M. D., & Bonner, J. C. (2018). The toxicology of engineered nanomaterials in asthma. Current Environmental Health Reports, 5(1), 100–109. https://doi.org/10.1007/s40572-018-0181-4

    Article  CAS  Google Scholar 

  • James, B. N., Oyeniran, C., Sturgill, J. L., Newton, J., Martin, R. K., Bieberich, E., Weigel, C., Maczis, M. A., Palladino, E. N. D., Lownik, J. C., Trudeau, J. B., Cook-Mills, J. M., Wenzel, S., Milstien, S., & Spiegel, S. (2021). Ceramide in apoptosis and oxidative stress in allergic inflammation and asthma. Journal of Allergy and Clinical Immunology, 147(5), 1936. https://doi.org/10.1016/j.jaci.2020.10.024

    Article  CAS  Google Scholar 

  • Kytikova, O. Y., Novgorodtseva, T. P., Denisenko, Y. K., Naumov, D. E., Gvozdenko, T. A., & Perelman, J. M. (2021). Thermosensory transient receptor potential ion channels and asthma. Biomedicines, 9(7), 816. https://doi.org/10.3390/biomedicines9070816

    Article  CAS  Google Scholar 

  • Lejeune, S., Sauvere, M., Chagnon, F., Cisterne, C., Mordacq, C., Thumerelle, C., Ducoin, H., Scalbert, M., Le Mee, A., Amani, M., et al. (2022). Impact of moisture/mould exposure on asthma control in children: The CHAMPIASTHMA study. European Respiratory Journal, 60(66), 2058. https://doi.org/10.1183/13993003.congress-2022.2058

    Article  Google Scholar 

  • Li, N., Georas, S., Alexis, N., Fritz, P., Xia, T., Williams, M., Horner, E., & Nel, A. (2016). A work group report on ultrafine particles (American Academy of Allergy, Asthma & Immunology): Why ambient ultrafine and engineered nanoparticles should receive special attention for possible adverse health outcomes in human subjects. Journal of Allergy and Clinical Immunology, 138(2), 386–396. https://doi.org/10.1016/j.jaci.2016.02.023

    Article  CAS  Google Scholar 

  • Lian, Z., Qi, H., Liu, X., Zhang, Y., Xu, R., Yang, X., Zeng, Y., & Li, J. (2022). Ambient ozone, and urban PM(2.5) co-exposure, aggravate allergic asthma via transient receptor potential vanilloid 1-mediated neurogenic inflammation. Ecotoxicology and Environmental Safety, 243, 114000. https://doi.org/10.1016/j.ecoenv.2022.114000

    Article  CAS  Google Scholar 

  • Liu, X., Zhong, C., Xie, J., Liu, H., Xie, Z., Zhang, S., & Jin, J. (2023). Geographical region traceability of Poria cocos and correlation between environmental factors and biomarkers based on a metabolomic approach. Food Chemistry, 417, 135817–135817. https://doi.org/10.1016/j.foodchem.2023.135817

    Article  CAS  Google Scholar 

  • Liu, Y., Wang, J., Guan, X., Yu, D., Huangfu, M., Dou, T., Zhou, L., Wang, L., Liu, G., Li, X., Zhai, Z., Han, M., Liu, H., & Chen, X. (2021). Mogroside V reduce OVA-induced pulmonary inflammation based on lung and serum metabolomics. Phytomedicine, 91, 153682. https://doi.org/10.1016/j.phymed.2021.153682

    Article  CAS  Google Scholar 

  • Lloyd, C. M., & Hawrylowicz, C. M. (2009). Regulatory T cells in asthma. Immunity, 31(3), 438–449. https://doi.org/10.1016/j.immuni.2009.08.007

    Article  CAS  Google Scholar 

  • Ma, Y., Deng, L., Ma, P., Wu, Y., Yang, X., Xiao, F., & Den, Q. (2021). In vivo respiratory toxicology of cooking oil fumes: Evidence, mechanisms and prevention. Journal of Hazardous Materials, 402, 123455. https://doi.org/10.1016/j.jhazmat.2020.123455

    Article  CAS  Google Scholar 

  • Mendell, M. J., Mirer, A. G., Cheung, K., Tong, M., & Douwes, J. (2011). Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence. Environmental Health Perspectives, 119(6), 748–756. https://doi.org/10.1289/ehp.1002410

    Article  CAS  Google Scholar 

  • Mishra, V., Baranwal, V., Mishra, R. K., Sharma, S., Paul, B., & Pandey, A. C. (2016). Titanium dioxide nanoparticles augment allergic airway inflammation and Socs3 expression via NF-kappa B pathway in murine model of asthma. Biomaterials, 92, 90–102. https://doi.org/10.1016/j.biomaterials.2016.03.016

    Article  CAS  Google Scholar 

  • Murray, C. J. L., Aravkin, A. Y., Zheng, P., Abbafati, C., Abbas, K. M., Abbasi-Kangevari, M., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., Abegaz, K. H., Abolhassani, H., Aboyans, V., Abreu, L. G., Abrigo, M. R. M., Abualhasan, A., Abu-Raddad, L. J., Abushouk, A. I., Adabi, M., & Lim, S. S. (2020). Global burden of 87 risk factors in 204 countries and territories, 1990–2019: A systematic analysis for the global burden of disease study 2019. Lancet, 396(10258), 1223–1249. https://doi.org/10.1016/S0140-6736(20)30752-2

    Article  Google Scholar 

  • Norton, S. K., Wijesinghe, D. S., Dellinger, A., Sturgill, J., Zhou, Z., Barbour, S., Chalfant, C., Conrad, D. H., & Kepley, C. L. (2012). Epoxyeicosatrienoic acids are involved in the C-70 fullerene derivative-induced control of allergic asthma. Journal of Allergy and Clinical Immunology, 130(3), 761. https://doi.org/10.1016/j.jaci.2012.04.023

    Article  CAS  Google Scholar 

  • Oh, J. H., Lee, S. Y., Cho, S. H., Chang, H. S., & Park, C. S. (2019). Novel plasma metabolite markers from arachidonic acid pathway for distinguishing refractory asthma. Journal of Allergy and Clinical Immunology, 143(2), AB298. https://doi.org/10.1016/j.jaci.2018.12.908

    Article  Google Scholar 

  • Paul, W. E., & Zhu, J. (2010). How are T(H)2-type immune responses initiated and amplified? Nature Reviews Immunology, 10(4), 225–235. https://doi.org/10.1038/nri2735

    Article  CAS  Google Scholar 

  • Pavon-Romero, G. F., Haydee Serrano-Perez, N., Garcia-Sanchez, L., Ramirez-Jimenez, F., & Teran, L. M. (2021). Neuroimmune pathophysiology in asthma. Frontiers in Cell and Developmental Biology, 9, 663535. https://doi.org/10.3389/fcell.2021.663535

    Article  Google Scholar 

  • Reinmuth-Selzle, K., Kampf, C. J., Lucas, K., Lang-Yona, N., Froehlich-Nowoisky, J., Shiraiwa, M., Lakey, P. S. J., Lai, S., Liu, F., Kunert, A. T., Ziegler, K., Shen, F., Sgarbanti, R., Weber, B., Bellinghausen, I., Saloga, J., Weller, M. G., Duschl, A., Schuppan, D., & Poeschl, U. (2017). Air pollution and climate change effects on allergies in the Anthropocene: Abundance, interaction, and modification of allergens and adjuvants. Environmental Science and Technology, 51(8), 4119–4141. https://doi.org/10.1021/acs.est.6b04908

    Article  CAS  Google Scholar 

  • Seurat, E., Verdin, A., Cazier, F., Courcot, D., Fitoussi, R., Vie, K., Momas, I., Desauziers, V., Seta, N., & Achard, S. (2021). Influence of the environmental relative humidity on the inflammatory response of skin model after exposure to various environmental pollutants. Environmental Research, 196, 110350. https://doi.org/10.1016/j.envres.2020.110350

    Article  CAS  Google Scholar 

  • Shurin, M. R., Yanamala, N., Kisin, E. R., Tkach, A. V., Shurin, G. V., Murray, A. R., Leonard, H. D., Reynolds, J. S., Gutkin, D. W., Star, A., Fadeel, B., Savolainen, K., Kagan, V. E., & Shvedova, A. A. (2014). Graphene oxide attenuates Th2-type immune responses, but augments airway remodeling and hyperresponsiveness in a murine model of asthma. ACS Nano, 8(6), 5585–5599. https://doi.org/10.1021/nn406454u

    Article  CAS  Google Scholar 

  • Silver, J. D., Sutherland, M. F., Johnston, F. H., Lampugnani, E. R., McCarthy, M. A., Jacobs, S. J., Pezza, A. B., & Newbigin, E. J. (2018). Seasonal asthma in Melbourne, Australia, and some observations on the occurrence of thunderstorm asthma and its predictability. PLoS ONE, 13(4), e0194929. https://doi.org/10.1371/journal.pone.0194929

    Article  CAS  Google Scholar 

  • Song, J., Kang, J., Lin, B., Li, J., Zhu, Y., Du, J., Yang, X., Xi, Z., & Li, R. (2017). Mediating role of TRPV1 ion channels in the co-exposure to PM2.5 and formaldehyde of Balb/c mice asthma model. Scientific Reports, 7, 11926. https://doi.org/10.1038/s41598-017-11833-6

    Article  CAS  Google Scholar 

  • Song, M., Liu, Y., Zhou, J., Shi, H., Su, X., Shao, M., Yang, Y., Wang, X., Zhao, J., Guo, D., Liu, Q., Zhang, L., Zhang, Y., Lv, L., & Li, W. (2023). Potential plasma biomarker panels identification for the diagnosis of first-episode schizophrenia and monitoring antipsychotic monotherapy with the use of metabolomics analyses. Psychiatry Research, 321, 115070. https://doi.org/10.1016/j.psychres.2023.115070

    Article  CAS  Google Scholar 

  • Thompson, E. A., Sayers, B. C., Glista-Baker, E. E., Shipkowski, K. A., Ihrie, M. D., Duke, K. S., Taylor, A. J., & Bonner, J. C. (2015). Role of signal transducer and activator of transcription 1 in murine allergen-induced airway remodeling and exacerbation by carbon nanotubes. American Journal of Respiratory Cell and Molecular Biology, 53(5), 625–636. https://doi.org/10.1165/rcmb.2014-0221OC

    Article  CAS  Google Scholar 

  • Thomson, N. C., Chaudhuri, R., Spears, M., Messow, C. M., Jelinsky, S., Miele, G., Nocka, K., Takahashi, E., Hilmi, O. J., Shepherd, M. C., Miller, D. K., & McSharry, C. (2014). Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking. Allergy, 69(4), 527–536. https://doi.org/10.1111/all.12376

    Article  CAS  Google Scholar 

  • Tuzova, M., Jean, J. C., Hughey, R. P., Brown, L. A. S., Cruikshank, W. W., Hiratake, J., & Joyce-Brady, M. (2014). Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma. Frontiers in Pharmacology, 5, 179. https://doi.org/10.3389/fphar.2014.00179

    Article  CAS  Google Scholar 

  • Voisin, T., & Chiu, I. M. (2018). Molecular link between itch and atopic dermatitis. Proceedings of the National Academy of Sciences of the United States of America, 115(51), 12851–12853. https://doi.org/10.1073/pnas.1818879115

    Article  CAS  Google Scholar 

  • Wang, M., & Deng, R. (2022). Effects of carbon black nanoparticles and high humidity on the lung metabolome in Balb/c mice with established allergic asthma. Environmental Science and Pollution Research, 29(43), 65100–65111. https://doi.org/10.1007/s11356-022-20349-0

    Article  CAS  Google Scholar 

  • Wang, M., Yao, G., Sun, Y., Yang, Y., & Deng, R. (2023). Exposure to construction dust and health impacts—A review. Chemosphere, 311, 136990. https://doi.org/10.1016/j.chemosphere.2022.136990

    Article  CAS  Google Scholar 

  • Wang, S., Tang, K., Lu, Y., Tian, Z., Huang, Z., Wang, M., Zhao, J., & Xie, J. (2021). Revealing the role of glycerophospholipid metabolism in asthma through plasma lipidomics. Clinica Chimica Acta, 513, 34–42. https://doi.org/10.1016/j.cca.2020.11.026

    Article  CAS  Google Scholar 

  • Wang, Z., Gao, S., Xie, J., & Li, R. (2019). Identification of multiple dysregulated metabolic pathways by GC-MS-based profiling of lung tissue in mice with PM2.5-induced asthma. Chemosphere, 220, 1–10. https://doi.org/10.1016/j.chemosphere.2018.12.092

    Article  CAS  Google Scholar 

  • Wright, R. J., Hsu, H. H. L., Chiu, Y. H. M., Coull, B. A., Simon, M. C., Hudda, N., Schwartz, J., Kloog, I., & Durant, J. L. (2021). Prenatal ambient ultrafine particle exposure and childhood asthma in the Northeastern United States. American Journal of Respiratory and Critical Care Medicine, 204(7), 788–796. https://doi.org/10.1164/rccm.202010-3743OC

    Article  CAS  Google Scholar 

  • Wu, Y., Duan, J., Li, B., Liu, H., & Chen, M. (2020). Exposure to formaldehyde at low temperatures aggravates allergic asthma involved in transient receptor potential ion channel. Environmental Toxicology and Pharmacology, 80, 103469. https://doi.org/10.1016/j.etap.2020.103469

    Article  CAS  Google Scholar 

  • Xu, M., Zhang, Y., Wang, M., Zhang, H., Chen, Y., Adcock, I. M., Chung, K. F., Mo, J., Zhang, Y., & Li, F. (2019). TRPV1 and TRPA1 in lung inflammation and airway hyperresponsiveness induced by fine particulate matter (PM2.5). Oxidative Medicine and Cellular Longevity, 2019, 7450151. https://doi.org/10.1155/2019/7450151

    Article  CAS  Google Scholar 

  • Xu, S., Panettieri, R. A., & Jude, J. (2022). Metabolomics in asthma: A platform for discovery. Molecular Aspects of Medicine, 85, 100990. https://doi.org/10.1016/j.mam.2021.100990

    Article  CAS  Google Scholar 

  • Yang, O., Lei, C., Chao, X., Xinjie, Z., & Zhenze, C. (2021). Liquid chromatography. Mass spectrometry-based metabolomics study of the efficacy of Chinese medicine asthma-relieving decoction on respiratory syncytial virus infection. Chinese Journal of Chromatography, 39(3), 281–290. https://doi.org/10.3724/SP.J.1123.2020.06013

    Article  CAS  Google Scholar 

  • Yi, M., Zhang, C., Zhang, Z., Yi, P., Xu, P., Huang, J., & Peng, W. (2020). Integrated metabolomic and lipidomic analysis reveals the neuroprotective mechanisms of Bushen Tiansui formula in an A beta 1–42-induced rat model of Alzheimer’s disease. Oxidative Medicine and Cellular Longevity, 2020, 5243453. https://doi.org/10.1155/2020/5243453

    Article  CAS  Google Scholar 

  • Yu, M., Jia, H. M., Cui, F. X., Yang, Y., Zhao, Y., Yang, M. H., & Zou, Z. M. (2017). The effect of Chinese herbal medicine formula mKG on allergic asthma by regulating lung and plasma metabolic alternations. International Journal of Molecular Sciences, 18(3), 602. https://doi.org/10.3390/ijms18030602

    Article  CAS  Google Scholar 

  • Zhang, Y., Hu, Z., Ye, M., Pan, Y., Chen, J., Luo, Y., Zhang, Y., He, L., & Wang, J. (2007). Effect of poly(ethylene glycol)-block-polylactide nanoparticles on hepatic cells of mouse: Low cytotoxicity, but efflux of the nanoparticles by ATP-binding cassette transporters. European Journal of Pharmaceutics and Biopharmaceutics, 66(2), 268–280. https://doi.org/10.1016/j.ejpb.2006.11.003

    Article  CAS  Google Scholar 

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (42207486) and China Postdoctoral Science Foundation (2021M700580).

Funding

This work was supported by the National Natural Science Foundation of China (42207486) and China Postdoctoral Science Foundation (2021M700580).

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Authors and Affiliations

  1. Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), School of Civil Engineering, Chongqing University, Chongqing, 400045, China

    Rui Deng & Mingpu Wang

  2. The Center for Clinical Molecular Medical Detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China

    Jia Li

  3. Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China

    Haiping Wu

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  1. Rui Deng
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Rui Deng was involved in Conceptualization, Methodology, Investigation, Funding acquisition, and Writing — original draft. Jia Li contributed to Validation and Writing — review & editing. Haiping Wu was involved in Methodology and Writing — review & editing. Mingpu Wang was involved in Investigation, Data curation, and Software.

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Deng, R., Li, J., Wu, H. et al. Mechanistic insight into the adjuvant effect of co-exposure to ultrafine carbon black and high humidity on allergic asthma. Environ Geochem Health 45, 9653–9667 (2023). https://doi.org/10.1007/s10653-023-01764-9

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  • DOI: https://doi.org/10.1007/s10653-023-01764-9

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