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Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency

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Abstract

Excessive fluoride consumption leads to accelerated red blood cell death and anaemia. Whether that increases the haematological alteration in subjects with haematological disorders (iron deficiency, thalassaemia, and G-6-PD deficiency) is still unclear. The fluoride in serum and urine and haematological parameters of students at Mae Tuen School (fluoride endemic area) were analysed and compared to those of students at Baan Yang Poa and Baan Mai Schools (control areas). Iron deficiency, thalassaemia, and G-6-PD deficiency were also diagnosed in these students. The students at Mae Tuen School had significantly (P < 0.001) higher levels of mean fluoride in the serum and urine than those in control areas. In both control and fluoride endemic areas, students with haematological disorders had significantly lower levels of Hb, Hct, MCV, MCH, and MCHC than those without haematological disorders. Moreover, the lowest levels of Hb, MCH, and MCHC were observed in the students with haematological disorders who live in the fluoride endemic area. Thus, the excessive fluoride consumption increased haematological alteration in subjects with iron deficiency, thalassaemia, and G-6-PD deficiency and that may increase the risk of anaemia in these subjects.

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Acknowledgments

The authors thank all students who participated in this study. We gratefully appreciate the help and assistance of Associate Professor Khunchai Ratanastien, Faculty of Associated Medical Sciences, Chiang Mai University and all staff at Baan Yang Poa, Baan Mai and Mae Tuen Schools, Omkoi District, Chiang Mai, Thailand. The authors wish to thank Dr. M. Kevin O Carroll, Professor Emeritus of the University of Mississippi School of Dentistry, USA and Faculty Consultant at Chiang Mai University Faculty of Dentistry, Thailand, for his assistance in the preparation of the manuscript. This study was supported by grants from the Chiang Mai University and the Intercountry Centre for Oral Health, Chiang Mai, Thailand.

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Authors and Affiliations

  1. Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, 110 Intawaroros Road, Chiang Mai, 50200, Thailand

    Sakorn Pornprasert, Fahsai Kantawong, Nattasit Pienthai, Jintana Yanola & Suwit Duangmano

  2. The Dental Research Center, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand

    Phenphichar Wanachantararak

  3. Intercountry Centre for Oral Health, Chiang Mai, Thailand

    Supoj Chamnanprai & Chatpat Kongpan

  4. Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand

    Mujalin Prasannarong

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  1. Sakorn Pornprasert
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  2. Phenphichar Wanachantararak
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  3. Fahsai Kantawong
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  4. Supoj Chamnanprai
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  9. Mujalin Prasannarong
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Correspondence to Sakorn Pornprasert.

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Pornprasert, S., Wanachantararak, P., Kantawong, F. et al. Excessive fluoride consumption increases haematological alteration in subjects with iron deficiency, thalassaemia, and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Environ Geochem Health 39, 751–758 (2017). https://doi.org/10.1007/s10653-016-9845-x

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