Skip to main content

Advertisement

Log in

Haematological changes in fluorotic adults and children in fluoride endemic regions of Gaya district, Bihar, India

  • Original Paper
  • Published:
Environmental Geochemistry and Health Aims and scope Submit manuscript

Abstract

Groundwater used for drinking and cooking was analysed for fluoride (F), and health surveys were conducted in Bodh Gaya, Amas and Bankebazaar blocks of the Gaya district, Bihar, India. Amas and Bankebazaar blocks were F endemic areas with mean F = 2.36 ± 0.23 mg/L (N = 27). Bodh Gaya was considered as control area with mean F = 0.59 ± 0.03 mg/L (N = 11). Health survey showed that more than 50 % of adults and more than 55 % of children had complaints of gastro-intestinal (GI) disturbances in the F endemic areas, while less than 20 % of adults and less than 10 % of children complained of GI problems in the control areas. Haematological analyses were conducted on age- and sex-matched fluorotic subjects (N = 93) of F endemic areas, and non-fluorotic subjects (N = 52) of control area showed lowered haemoglobin, haematocrit, mean corpuscular volume, mean corpuscular haemoglobin, and mean corpuscular haemoglobin concentration in the fluorotic subjects, suggesting the occurrence of anaemia in the fluorotic subjects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Banu Priya, C. A. Y., Anitha, K., Murali Mohan, E., Pillai, K. S., & Murthy, P. B. (1997). Toxicity of fluoride to diabetic rats. Fluoride, 30(1), 51–58.

    Google Scholar 

  • Burhan, U. (1981). Effect of fluoride on hemoglobin and hematocrit. Fluoride, 14, 38–41.

    Google Scholar 

  • Choubisa, S. L. (1996). Prevalence of fluorosis in some villages of Dungarpur district of Rajasthan. Indian Journal of Environmental Health, 38, 119–126.

    CAS  Google Scholar 

  • Das, T. K., Susheela, A. K., Gupta, I. P., Dasarathy, S., & Tandon, R. K. (1994). Toxic effects of chronic fluoride ingestion on upper gastro-intestinal tract. Journal of Clinical Gastroenterology, 18, 194–199.

    Article  CAS  Google Scholar 

  • Dasarathy, S., Das, T. K., Gupta, I. P., Susheela, A. K., & Tandon, R. K. (1996). Gastroduodenal manifestations in patients with skeletal fluorosis. Journal of Gastroenterology, 31, 333–337.

    Article  CAS  Google Scholar 

  • Eren, E., Ozturk, M., Mumcu, E. F., & Canatan, D. (2005). Fluorosis and its hematological effects. Toxicology and Industrial Health, 21(10), 255–258.

    Article  CAS  Google Scholar 

  • Ersoy, I. H., Alanoglu, E. G., Koroglu, B. K., Varol, S., Akcay, S., Ugan, Y., et al. (2010). Effect of endemic fluorosis on hematological parameters. Biological Trace Element Research, 138(1–3), 22–27.

    Article  CAS  Google Scholar 

  • Fawell, J., Bailey, K., Chilton, J., Dahi, E., Fewtrell, L., & Magara, Y. (2006). Fluoride in drinking-water. London: IWA Publishing.

    Google Scholar 

  • Fowles, J. R., Fairbrother, A., & Kerkvliet, N. I. (1997). Effect of induced hypo- and hyperthyroidism on immune function and plasma biochemistry in mallards. Comparative Biochemistry and Physiology, 118, 213–220.

    CAS  Google Scholar 

  • Gupta, I. P., Das, T. K., Susheela, A. K., Dasarathy, S., & Tandon, R. K. (1992). Alimentary tract and pancreas: Fluoride as possible etiological factor in non-ulcer dyspepsia. Journal of Gastroenterology and Hepatology, 7, 355–359.

    Article  CAS  Google Scholar 

  • Jafarzadeh, A., Poorholami, M., Izadi, N., Nemati, M., & Rezayati, M. (2010). Immunological and haematological changes in patients with hyperthyroidism or hypothyroidism. Clinical and Investigative Medicine, 33(5), E271–E279.

    CAS  Google Scholar 

  • Jaganmohan, P., Narayana Rao, S. V. L., & Sambasiva Rao, K. R. S. (2010). Biochemical and haematological investigation on fluorosis threaten patients at Nellore district, Andhra Pradesh, India. World Journal of Medical Sciences, 5(3), 54–58.

    Google Scholar 

  • Kant, V., Verma, P. K., Pankaj, N. K., Kumar, J., Kusum, Raina, R., & Srivastava, A. K. (2009). Haematological profile of subacute oral toxicity of fluoride and ameliorative efficacy of aluminium sulphate in goats. Toxicology International, 16(1), 31–35.

  • Khandare, A. L., Harikumar, R., & Sivakumar, B. (2005). Severe borne deformities in young children from Vit D deficiency and fluorosis in Bihar-India. Calcified Tissue International, 76, 412–418.

    Article  CAS  Google Scholar 

  • Kumar, T., & Takalkar, A. (2010). Study of the effects of drinking water naturally contaminated with fluorides on the health of children. Biomedical Research, 21, 423–427.

    CAS  Google Scholar 

  • Mohiuddin, S. M., & Reddy, M. V. (1989). Haematological and biochemical studies on fluoride toxicity in sheep. The Indian Veterinary Journal, 66, 1089–1091.

    CAS  Google Scholar 

  • National Research Council (NRC) (2006). Fluoride in drinking-water. A Scientific review of EPA’s standards, Washington, DC.

  • Pillai, K. S., Mathai, A. T., & Deshmukh, P. B. (1988). Effect of subacute dosage of fluoride on male mice. Toxicology Letters, 44, 21–29.

    Article  CAS  Google Scholar 

  • Rajiv Gandhi National Drinking Water Mission (RGNDWM). (1993). Health Aspects (Vol. 1). New Delhi: Ministry of Rural Development.

    Google Scholar 

  • Rao, A. V. B., & Vidyunmala, S. (2010). Cumulative effect of fluoride on hematological indices of mice, mus norvegicus albinus. American-Eurasian Journal of Toxicological Sciences, 2(2), 93–95.

    Google Scholar 

  • Sharma, J. D., Jain, P., & Sohu, D. (2009). Gastric discomforts from fluoride in drinking water in Sanganer Tehsil, Rajasthan, India. Fluoride, 42, 286–291.

    CAS  Google Scholar 

  • Singh, J. L., & Swarup, D. (1994). Fluorosis in buffaloes. The Veterinary Record, 135(11), 260–261.

    Article  CAS  Google Scholar 

  • Susheela, A. K. (1987). Fluorosis in India, the magnitude and severity of the problem. Sci Dev Environ, 147–157.

  • Susheela, A. K. (1995). Epidemiological studies of health risks from drinking water naturally contaminated with fluoride. In: Assessing and managing health risks from drinking water contamination: Approaches and applications: Proceedings of the Rome symposium Vol. 233, pp. 123–134.

  • Susheela, A. K., Das, T. K., Gupta, I. P., Tandon, R. K., Kacker, S. K., Ghosh, P., et al. (1992). Fluoride ingestion and its correlation with gastro-intestinal discomfort. Fluoride, 25, 5–22.

    Google Scholar 

  • Susheela, A. K., & Jain, S. K. (1983). Fluoride-induced hematological changes in rabbits. Bulletin of Environment Contamination and Toxicology, 30, 388–393.

    Article  CAS  Google Scholar 

  • Susheela AK, Jain SK (1986). Erythrocyte membrane abnormality and echinocyte formation. In: Proceedings of the 14th conference of the international society for fluoride research, Japan, Elsevier Publishing House, Amsterdam.

  • Susheela, A. K., Kumar, A., Bhatnagar, M., & Bahadur, R. (1993). Prevalence of endemic fluorosis with gastrointestinal manifestations in people living in some North-Indian villages. Fluoride, 26(2), 97–104.

    Google Scholar 

  • Susheela, A. K., Mondal, N. K., Gupta, R., Ganesh, K., Brahmankar, S., Bhasin, S., et al. (2010). Effective interventional approach to control anaemia in pregnant women. Current Science, 98(10), 1320–1330.

    CAS  Google Scholar 

  • Susheela, A. K., Mondal, N. K., & Singh, A. (2013). Exposure to fluoride in smelter workers in a primary aluminium industry in India. The International Journal of Occupational and Environmental Medicine, 4, 61–72.

    CAS  Google Scholar 

  • Swarup, D., & Singh, Y. P. (1989). Bovine fluorosis in a brick kiln congested zone. Indian Journal of Veterinary Medicine, 9, 12–14.

    Google Scholar 

  • Viswanathan, G., Jaswanth, A., Gopalakrishnan, S., & Siva Ilango, S. (2009). Mapping of fluoride endemic areas and assessment of fluoride exposure. Science of the Total Environment, 407(5), 1579–1587.

    Article  CAS  Google Scholar 

  • Yasmin, S., Monterio, S., Ligimol, P. A., & D’Souza, D. (2011). Fluoride contamination and fluorosis in Gaya Region of Bihar, India. Current Biotica, 5(2), 232–236.

    Google Scholar 

Download references

Acknowledgments

We are grateful to the University Grants Commission (UGC), New Delhi for the financial support under the Major Project Scheme (F. No. 40-399/2011 SR).

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shahla Yasmin.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yasmin, S., Ranjan, S. & D’Souza, D. Haematological changes in fluorotic adults and children in fluoride endemic regions of Gaya district, Bihar, India. Environ Geochem Health 36, 421–425 (2014). https://doi.org/10.1007/s10653-013-9570-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10653-013-9570-7

Keywords

Navigation