Abstract
Purpose
To report a case of linezolid-induced reversible retinopathy.
Methods
Case report with literature review.
Results
Clinical examination and imaging are presented over a 7-month interval, from initial presentation to subsequent follow-up (6 months after discontinuation of linezolid). The subject was found to have not only an optic neuropathy but also severe reversible photoreceptor dysfunction as demonstrated by electrophysiologic testing. Upon discontinuation of linezolid, not only did the patient’s visual acuity, visual fields, and visual evoked potential significantly improve, but the electroretinogram did as well.
Conclusions
Linezolid has previously been reported to cause a toxic optic neuropathy. Reversible photoreceptor dysfunction on full-field electroretinography has never been reported in conjunction with linezolid toxicity. This novel case suggests that linezolid toxicity should be considered in cases of photoreceptor dysfunction.
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Acknowledgements
We are thankful for the participation of the patient.
Funding
This report was supported by funding from Search for Vision (Chicago, IL), National Eye Institute (Bethesda, MD) R01EY023644, departmental core Grant EY001792, and Research to Prevent Blindness (New York, NY) (departmental support). The funding organizations had no role in the design or conduct of this research.
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Kayliana J. Wesby, MS, assisted in drafting and editing the manuscript. Poulami Borkar, MBBS, assisted in editing the manuscript.
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10633_2019_9725_MOESM1_ESM.jpg
Supplemental Fig. 1. SD-OCT. Bilateral macular OCT reveals drusen. Subfoveally in both eyes, there is vitelliform material. No inter- or subretinal fluid from associated choroidal neovascularization is evident. (JPEG 224 kb)
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Grohmann, S.M., Berman, A. & Grassi, M.A. Linezolid-induced photoreceptor dysfunction masquerading as autoimmune retinopathy. Doc Ophthalmol 140, 77–82 (2020). https://doi.org/10.1007/s10633-019-09725-3
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DOI: https://doi.org/10.1007/s10633-019-09725-3