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Linezolid induced retinopathy

  • Clinical Case Report
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Abstract

Purpose

While optic neuropathy is a well-known cause of visual disturbances in linezolid-treated patients, the possibility of linezolid-related retinopathy has not been investigated. Here, we report a case of retinopathy demonstrated by multifocal electroretinogram (mfERG) in a linezolid-treated patient.

Method and results

A 61-year-old man with extensively drug-resistant pulmonary tuberculosis treated with linezolid for 5 months presented with painless loss of vision in both eyes. The patient’s best corrected visual acuity was 20/50 in the right eye and 20/100 in the left eye. Fundus examination revealed mild disc edema, and color vision was defective in both eyes. Humphrey visual field tests showed a superotemporal field defect in the right eye and central and pericentral field defect in the left eye. Optical coherence tomography (OCT) revealed only mild optic disc swelling. In mfERG, central amplitudes were depressed in both eyes. Four months after the cessation of linezolid, visual acuity was restored to 20/20 right eye and 20/25 left eye. The color vision and visual field had improved. The OCT and mfEFG findings improved as well.

Conclusions

Although the clinical features were similar to linezolid-induced optic neuropathy, the mfERG findings suggest the possibility of a retinopathy through cone dysfunction.

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Acknowledgments

This report is supported in part from Soonchunhyang University Research Fund.

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Authors and Affiliations

  1. Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, #170 Jomaru-ro, Wonmi-gu, Bucheon, 420-767, Korea

    Dae Hyun Park, Tae Kwann Park, Young-Hoon Ohn & Jee Ho Chang

  2. Division of Pulmonology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea

    Jong Sook Park

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  1. Dae Hyun Park
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  2. Tae Kwann Park
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Correspondence to Jee Ho Chang.

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Conflict of interest

All authors Dae Hyun Park, Tae Kwann Park, Young-Hoon Ohn, Jong Sook Park, Jee Ho Chang declared that they have no conflict of interest.

Ethical approval

The diagnostic procedures incurred in this case followed usual patient caring situations. No special intervention or test involved this case. Although we did obtain usual clinical consents for the diagnostic test, we don't think this manuscript needs particular statements concerning research ethics.

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Park, D.H., Park, T.K., Ohn, YH. et al. Linezolid induced retinopathy. Doc Ophthalmol 131, 237–244 (2015). https://doi.org/10.1007/s10633-015-9518-6

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  • DOI: https://doi.org/10.1007/s10633-015-9518-6

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