Skip to main content
Log in

Low Sensitivity of Fecal Immunochemical Tests (FIT) for Detection of Sessile Serrated Adenomas/Polyps Confirmed Over Clinical Setting, Geography, and FIT System

  • Correspondence
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Cock C, Anwar S, Byrne SE, et al. Low sensitivity of fecal immunochemical tests and blood-based markers of DNA hypermethylation for detection of sessile serrated adenomas/polyps. Dig Dis Sci. 2019. (Epub ahead of print). https://doi.org/10.1007/s10620-019-05569-8.

  2. Young GP, Symonds EL, Allison JE, et al. Advances in fecal occult blood tests: the FIT revolution. Dig Dis Sci. 2015;60:609–622. https://doi.org/10.1007/s10620-014-3445-3.

    Article  PubMed  Google Scholar 

  3. Westwood M, Lang S, Armstrong N, et al. Faecal immunochemical tests (FIT) can help to rule out colorectal cancer in patients presenting in primary care with lower abdominal symptoms: a systematic review conducted to inform new NICE DG30 diagnostic guidance. BMC Med. 2017;15:189. https://doi.org/10.1186/s12916-017-0944-z.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Grobbee EJ, van der Vlugt M, van Vuuren AJ, et al. A randomised comparison of two faecal immunochemical tests in population-based colorectal cancer screening. Gut. 2017;66:1975–1982. https://doi.org/10.1136/gutjnl-2016-311819.

    Article  CAS  PubMed  Google Scholar 

  5. McDonald PJ, Strachan JA, Digby J, et al. Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer. Clin Chem Lab Med. 2011;50:935–940. https://doi.org/10.1515/CCLM.2011.815.

    Article  CAS  PubMed  Google Scholar 

  6. Symonds EL, Osborne JM, Cole SR, et al. Factors affecting faecal immunochemical test positive rates: demographic, pathological, behavioural and environmental variables. J Med Screen. 2015;22:187–193. https://doi.org/10.1177/0969141315584783.

    Article  PubMed  Google Scholar 

  7. Digby J, McDonald PJ, Strachan JA, et al. Deprivation and faecal haemoglobin: implications for bowel cancer screening. J Med Screen. 2014;21:95–97. https://doi.org/10.1177/0969141314535388.

    Article  PubMed  Google Scholar 

  8. Fraser CG, Rubeca T, Rapi S, et al. Faecal haemoglobin concentrations vary with sex and age, but data are not transferable across geography for colorectal cancer screening. Clin Chem Lab Med. 2014;52:1211–1216. https://doi.org/10.1515/cclm-2014-0115.

    Article  CAS  PubMed  Google Scholar 

  9. National Institute for Health and Care Excellence. Quantitative faecal immunochemical tests to guide referral for colorectal cancer in primary care. Diagnostics Guidance [DG30]. July 2017. https://www.nice.org.uk/guidance/dg30.

  10. Digby J, Fraser CG, Carey FA, et al. Faecal haemoglobin concentration is related to severity of colorectal neoplasia. J Clin Pathol. 2013;66:415–419. https://doi.org/10.1136/jclinpath-2013-201445.

    Article  CAS  PubMed  Google Scholar 

  11. Bettington M, Walker N, Rosty C, et al. Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma. Gut. 2017;66:97–106. https://doi.org/10.1136/gutjnl-2015-310456.

    Article  CAS  PubMed  Google Scholar 

  12. Li D, Woolfrey J, Jiang SF, et al. Diagnosis and predictors of sessile serrated adenoma after educational training in a large, community-based, integrated healthcare setting. Gastrointest Endosc. 2018;87:755–765. https://doi.org/10.1016/j.gie.2017.08.012.

    Article  PubMed  Google Scholar 

  13. IJspeert J, de Wit K, van der Vlugt M, et al. Prevalence, distribution and risk of sessile serrated adenomas/polyps at a center with a high adenoma detection rate and experienced pathologists. Endoscopy. 2016;48:740–746. https://doi.org/10.1055/s-0042-105436.

    Article  PubMed  Google Scholar 

  14. Snover D, Ahnen D, Burt R, Odze R. Serrated polyps of the colon and rectum and serrated polyposis. In: Bosman F, et al., eds. World Health Organisation Classification of Tumours of the Digestive System. Lyon: IARC Press; 2010.

    Google Scholar 

  15. Rex DK, Ahnen DJ, Baron JA, et al. Serrated lesions of the colorectum: review and recommendations from an expert panel. Am J Gastroenterol. 2012;107:1315–1329. https://doi.org/10.1038/ajg.2012.161.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Callum G. Fraser.

Ethics declarations

Conflict of interest

CGF undertakes paid consultancy with Kyowa Medex Co., Ltd, Tokyo, Japan, and has received financial assistance with attendance at conferences from Alpha Labs Ltd. All other authors declare that they have no conflicts of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mowat, C., Digby, J., Strachan, J.A. et al. Low Sensitivity of Fecal Immunochemical Tests (FIT) for Detection of Sessile Serrated Adenomas/Polyps Confirmed Over Clinical Setting, Geography, and FIT System. Dig Dis Sci 64, 3024–3026 (2019). https://doi.org/10.1007/s10620-019-05661-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-019-05661-z

Navigation