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Imidazolium-Sulfobetaine Based on Betulin with Proliferative Activity for HEK293 and T-Lymphocyte Cells

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Chemistry of Natural Compounds Aims and scope

A betulin derivative with an (imidazolium)butane-1-sulfonate fragment was synthesized and promoted proliferation in vitro of HEK293 and human T-lymphocyte cells, suggesting that this compound had immunostimulant properties.

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Acknowledgment

The work was performed on topics of State Tasks for UfIC, RAS (No. AAAA-A17-117011910025-6 and

No. AAAA-A17-117011910027-0) and IBG, UFRC, RAS (No. AAAA-A16-116020350033-8) using equipment at the Khimiya CUC, UfIC, UFRC, RAS. Biological studies used equipment at Biomika CUC (Division of Biochemical Research Methods and Nanobiotechnology, RCUC Agidel, Ufa) and UNU KODINK.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, 450054, Russia

    N. G. Komissarova, A. V. Orlov & M. S. Yunusov

  2. Neftekhim Pilot Plant Inc., 14 Initsiativnaya St., Ufa, 450065, Russia

    S. N. Dubovitskii

  3. Ufa State Petroleum Technological University, 1 Kosmonavtov St., Ufa, 450062, Russia

    O. V. Shitikova

  4. Institute of Biochemistry and Genetics, Special Structural Subdivision of Ufa Federal Research Center, Russian Academy of Sciences, 71 Prosp. Oktyabrya, Ufa, 450054, Russia

    V. A. Vakhitov, L. F. Zainullina & Yu. V. Vakhitova

Authors
  1. N. G. Komissarova
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  2. S. N. Dubovitskii
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  3. A. V. Orlov
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  4. O. V. Shitikova
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  5. V. A. Vakhitov
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  6. L. F. Zainullina
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  7. Yu. V. Vakhitova
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  8. M. S. Yunusov
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Corresponding author

Correspondence to N. G. Komissarova.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2019, pp. 415–419.

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Komissarova, N.G., Dubovitskii, S.N., Orlov, A.V. et al. Imidazolium-Sulfobetaine Based on Betulin with Proliferative Activity for HEK293 and T-Lymphocyte Cells. Chem Nat Compd 55, 485–489 (2019). https://doi.org/10.1007/s10600-019-02721-8

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  • DOI: https://doi.org/10.1007/s10600-019-02721-8

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