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Synthetic transformations of sesquiterpene lactones. V.* Synthesis and cytotoxicity of 13-aryl-substituted tourneforin derivatives

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Chemistry of Natural Compounds Aims and scope

13-Aryl-substituted tourneforin derivatives were synthesized via the Heck reaction with aryliodides. The structure of (E)-13-(3,4-dimethoxybenzyl)-eudesma-4(5),11(13)-dien-6α,12-olide was confirmed by an XSA. A study of the cytotoxicity of the synthesized derivatives for CEM-13, MT-4, and U-937 tumor models showed promise for the modification.

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Acknowledgment

The work was supported financially by an Integrated Project of the SB, RAS, with organizations of CIS countries (No. 79).

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Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    E. E. Shulˈts, S. S. Patrushev, A. V. Belovodskii, M. M. Shakirov, T. V. Rybalova & G. A. Tolstikov

  2. Novosibirsk State University, Novosibirsk, Russia

    S. S. Patrushev, A. G. Pokrovskii & M. A. Pokrovskii

  3. International Scientific-Production Holding Fitokhimiya, 100009, Karaganda, Republic of Kazakhstan

    S. M. Adekenov

Authors
  1. E. E. Shulˈts
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  2. S. S. Patrushev
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  3. A. V. Belovodskii
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  4. M. M. Shakirov
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  5. T. V. Rybalova
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  6. A. G. Pokrovskii
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  7. M. A. Pokrovskii
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  8. G. A. Tolstikov
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  9. S. M. Adekenov
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Corresponding author

Correspondence to E. E. Shulˈts.

Additional information

*For No. IV, see Ref. [1].

Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2012, pp. 221–224.

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Shulˈts, E.E., Patrushev, S.S., Belovodskii, A.V. et al. Synthetic transformations of sesquiterpene lactones. V.* Synthesis and cytotoxicity of 13-aryl-substituted tourneforin derivatives. Chem Nat Compd 48, 245–249 (2012). https://doi.org/10.1007/s10600-012-0214-4

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  • DOI: https://doi.org/10.1007/s10600-012-0214-4

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