Abstract
Despite the developments in cancer research over years, cancer is still one of the leading causes of death worldwide. In Brazil, the number of cancer cases for the several next years (2020–2022) is expected to increase up to 625,000. Thus, translational research has been vital to determine the potential risk, prognostic, and predictive biomarkers in cancer. Therefore, Barretos Cancer Hospital implemented a biobank (BB-BCH) in 2006, which is responsible for processing, storage, and provision of biological materials from cancer and non-cancer participants. Hence, this article aimed to describe BB-BCH’s history, experiences, and outcomes and explore its impact on Brazilian translational oncology research scenario. BB-BCH has a multidisciplinary team who are responsible for guaranteeing the quality of all processes as recommended by international guidelines for biobanks. Furthermore, BB-BCH has ample equipment to ensure the quality of all material requested by researchers as genetic material (DNA and RNA) and/or entire biospecimens. From 2006 to 2019, BB-BCH contained 252,069 samples from 44,933 participants, the whole collection is represented by 15 different types of biospecimens collected from them. According to our data, the most collected and stored topography in men is head and neck (29%); in women is breast (28%); and in children is torso and limb (27%) samples. Finally, we supported national and international consortia and projects such as The Cancer Genome Atlas. BB-BCH is a vital knowledge source for scientific community, enabling the development of high-quality studies, with a wide variety of tumor categories and high national representativeness of Brazilian population.
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Availability of data and materials
The datasets generated and/or analyzed during the current study are not publicly available due to it is confidentiality once it involved patients personal information but are available from the corresponding author on reasonable request.
Code Availability
Not Applicable.
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Acknowledgements
The authors are grateful to the Barretos Cancer Hospital, including all departments involved in the creation and collection of specimens, particularly the Pathology Department and Surgical Center, national and international partners, and all participants who agreed to donate their biological samples, enabling the formation of this collection.
Funding
This work was funded by the Financier of Studies and Projects (Finaciadora de Estudos e Projeto do Ministério da Ciência e Tecnologia - FINEP), the Public Ministry of Labor (Ministério Público do Trabalho - MPT), Barretos Cancer Hospital (BCH) and the São Paulo Research Foundation (Fundação de Amparo à Pesquisa do Estado de São Paulo–FAPESP/Protocol 2018/22100-0).
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ACN performed the preparation of tables, figure, gathered data information and wrote the manuscript. CHT gathered information related with biobank data. AGR performed the preparation of tables, figure and wrote the manuscript. GTM, TTK and CDR wrote the manuscript and revised it. VDS pathologist and BB-BCH vice-coordinator supervised the manuscript and its development. ECM and RMR provided advice during the study development and critically reviewed the manuscript. MMCM designed the project, supervised the research development, and wrote all the manuscript. All authors have read and approved the final version of the manuscript.
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Neuber, A.C., Tostes, C.H., Ribeiro, A.G. et al. The biobank of barretos cancer hospital: 14 years of experience in cancer research. Cell Tissue Bank 23, 271–284 (2022). https://doi.org/10.1007/s10561-021-09941-9
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DOI: https://doi.org/10.1007/s10561-021-09941-9