Abstract
Histopathological examination of brain tissue is required for better understanding of neurodegenerative conditions such as Parkinson’s disease and related disorders. However, patient willingness remains the greatest hurdle hampering participation in brain donation for research. While there is extensive research being conducted on the subject in West, to the best of our knowledge, there are no studies done in this regard in Asia. This cross-sectional survey was conducted on 105 Parkinson’s disease patients to assess their knowledge, beliefs and attitude towards brain donation in an Asian population. The majority of the participants (78%) acknowledged the importance of donation of brain for research, and 70% believed that their donated brain samples would be handled professionally. Fifty percent participants were willing to consider donating their brain for research. Motivating factors for brain donation included altruism (87%) and contribution to advance medical knowledge (80%). Common reasons for unwillingness towards brain donation were stress for family (30%), disfigurement of body (25%), and having a conservative mindset (23%). About one-third of the participants preferred to be approached for brain donation after their first clinic visit. Most patients preferred either their treating neurologists (66%) or research staff (18%) to discuss brain donation with. Participation for brain donation may be increased further with greater patient and public education to overcome misconceptions and change mindsets.
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Acknowledgements
We would like to thank all participants for their contribution, and neurologists from the National Neuroscience Institute, Singapore for referring their patients for the study.
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The research is supported by the Singapore National Research Foundation under its Translational and Clinical Flagship Programme (TCR12dec010) and administered by the Singapore Ministry of Health’s National Medical Research Council.
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Conceptualisation: LCS Tan, SJUA and JYJF; Methodology: LCST, SJUA and JYJF; Statistical Analysis: NSYC and JYJF; Data Curation: JYJF and NSYC; Writing SK, JYJF and NSYC; Review and Editing: LCST, SK, SXMN and NSYC; Supervision: LCST, ASLN, W-LA and K-YT; Recruitment: LCST, ASLN, W-LA, K-YT, SXMN, JYJF and NSYC; Project Administration: LCST, SJUA, JYJF and NSYC; Funding Acquisition: LCST.
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The ethical committee approval was provided by the Singapore Health Services Centralised Institutional Review Board. Informed consent was waived for this study as it did not require collection of personal identifiers, hence involved no more than minimal risk to its participants.
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Khan, S., Foo, J.Y.J., Chia, N.S.Y. et al. Attitudes of Asian Parkinson patients towards brain donation. Cell Tissue Bank 20, 585–590 (2019). https://doi.org/10.1007/s10561-019-09788-1
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DOI: https://doi.org/10.1007/s10561-019-09788-1