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Echocardiographic parameters of left ventricular structure and diastolic function and their relation to coronary artery calcification

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Abstract

Alteration in left ventricular (LV) structure and diastolic function is associated with poor cardiovascular (CV) prognosis. Coronary artery calcium score (CACS) is a reliable marker for coronary artery calcification, predicting adverse CV events. However, evidence is still insufficient to establish the association between alteration in LV structure and diastolic function and CACS. 9053 Korean adults (male: 84.2%, mean age: 42.5 years) were grouped by quartile levels of echocardiographic parameters for LV structure and diastolic function. CACS was detected by multidirectional computed tomography and categorized into CACS > 0 or CACS = 0. Multivariate regression analysis was used to calculate adjusted odd ratios (OR) and 95% confidence interval (CI) for CACS > 0 (adjusted OR [95% CI]) in each quartile group of echocardiographic parameters (reference: quartile 1 group). CACS > 0 was significantly associated with structural parameters above third quartile in LVMI (1.19 [1.00–1.41]), RWT (1.23 [1.03–1.46]) and IVST (1.42 [1.20–1.70]) and fourth quartile in PWT (1.36 [1.14–1.63]). In parameters of diastolic function, septal eʹ velocity ≥ 10.7 cm/s (fourth quartile) was less associated with CACS > 0 than septal eʹ velocity ≤ 7.7 cm/s (first quartile). Additionally, the fourth quartile of E/eʹ was more significantly associated with CACS > 0 than that of first quartile. Echocardiographic parameters close to LV hypertrophy and LV diastolic dysfunction are associated with CACS > 0.

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Acknowledgements

This study was based on medical data collected and arranged by Kangbuk Samsung Cohort Study (KSCS). Therefore, this study could be done by virtue of the labor of all staffs working in KSCS and Total Healthcare Center, Kangbuk Samsung Hospital.

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This research received no grant from any funding agency in the public, commercial or not-for-profit sectors.

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Authors and Affiliations

  1. Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Sung Keun Park

  2. Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Mdicine, 67, Sejong-daero, Jung-gu, Seoul, 04514, Republic of Korea

    Jeong Gyu Kang, Hyo Sun Seok & Ju Young Jung

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  1. Sung Keun Park
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  2. Jeong Gyu Kang
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  3. Hyo Sun Seok
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Correspondence to Ju Young Jung.

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Ethics approvals for the study protocol and analysis of the data were obtained from the institutional review board of Kangbuk Samsung Hospital.

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Park, S.K., Kang, J.G., Seok, H.S. et al. Echocardiographic parameters of left ventricular structure and diastolic function and their relation to coronary artery calcification. Int J Cardiovasc Imaging 37, 2861–2869 (2021). https://doi.org/10.1007/s10554-021-02256-6

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  • DOI: https://doi.org/10.1007/s10554-021-02256-6

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