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A review of serial coronary computed tomography angiography (CTA) to assess plaque progression and therapeutic effect of anti-atherosclerotic drugs

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Abstract

Change in coronary artery plaque on serial catheter intravascular ultrasound (IVUS) is an established technique to monitor the therapeutic effect of drugs on coronary atherosclerosis. Recent advances in coronary computed tomography angiography (CTA) now allow for non-invasive assessment of change in coronary plaque. Because coronary CTA is noninvasive, it enables clinical trials with lower-risk populations, higher retention rates, and lower costs. This review presents an overview of serial coronary CTA as a noninvasive imaging technique to gauge the therapeutic effect of anti-atherosclerotic therapies. Furthermore, it reviews the increasing use of serial CTA as an imaging endpoint in completed and ongoing clinical trials.

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Authors and Affiliations

  1. Department of Radiology, Cardiovascular Imaging Research Center, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Boston, MA, 02114, USA

    Jana Taron, Udo Hoffmann & Michael T. Lu

  2. Department for Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany

    Jana Taron

  3. Division of Rheumatology/Immunology/Pulmonology, Emory University School of Medicine, Atlanta, USA

    Saeyun Lee

  4. Cardiovascular Imaging Core Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA

    John Aluru

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  1. Jana Taron
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Correspondence to Jana Taron.

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Conflict of interest

Dr. Lu reported research funding as a co-investigator to MGH from Kowa Company Limited and Medimmune/Astrazeneca and receiving personal fees from PQBypass unrelated to this work. He reports a research grant from the Nvidia Corporation Academic Program. Dr. Hoffmann reported receiving research support on behalf of his institution from Duke University (Abbott), HeartFlow, Kowa Company Limited, and MedImmune/Astrazeneca; and receiving consulting fees from Duke University (NIH), and Recor Medical unrelated to this research. Dr. Taron was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – TA 1438/1-1.

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Taron, J., Lee, S., Aluru, J. et al. A review of serial coronary computed tomography angiography (CTA) to assess plaque progression and therapeutic effect of anti-atherosclerotic drugs. Int J Cardiovasc Imaging 36, 2305–2317 (2020). https://doi.org/10.1007/s10554-020-01793-w

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