Abstract
Repeatability of quantitative assessment of atherosclerotic plaques is important for the accurate detection of high-risk plaques in coronary CT angiography (CTA). We assessed the effect of heart rate (HR) on plaque CT number using a coronary artery model and a cardiac phantom capable of simulating cardiac motion. The coronary artery model with luminal stenosis on a cardiac phantom was imaged with a simulated HR of 0, 50, 60, and 70 beats per minute using a 320-row CT scanner. We reconstructed CT images for cardiac diastolic phases (for 75% R–R interval) using filtered back projection (FBP), hybrid iterative reconstruction (AIDR3D), and model-based iterative reconstruction (FIRST). Two observers measured plaque attenuation in the lesion with 75% stenosis. The coefficient of determination (R2) was obtained to evaluate interobserver agreement. At HR 70, FIRST improved the correlation between two observers compared with FBP and AIDR3D (FIRST: R2 = 0.68, p < 0.05; FBP: R2 = 0.29, p = 0.31; AIDR3D: R2 = 0.22, p = 0.18). These R2 at HR 70 were lower compared with at HR 50 (FIRST: R2 = 0.92, p < 0.05; FBP: R2 = 0.83, p < 0.05; AIDR3D: R2 = 0.87, p < 0.05) and HR 0 (FIRST: R2 = 0.97, p < 0.05; FBP: R2 = 0.89, p < 0.05; AIDR3D: R2 = 0.95, p < 0.05). Higher HR affected plaque measurement repeatability in coronary CTA. FIRST may improve plaque measurement repeatability at the higher HR compared with FBP and AIDR3D.
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Abbreviations
- CTA:
-
Computed tomography angiography
- HU:
-
Hounsfield unit
- IVUS:
-
Intravascular ultrasound
- HR:
-
Heart rate
- BPM:
-
Beats per minute
- FBP:
-
Filtered back projection
- AIDR3D:
-
Adaptive iterative dose reduction 3D
- FIRST:
-
Forward projected model-based iterative reconstruction solution
- ROI:
-
Region of interest
- SD:
-
Standard deviation
- ICC:
-
Intraclass correlation coefficients
- LoA:
-
Limits of agreement
- CAD-RADs:
-
Coronary Artery Disease Reporting and Data System
- MD:
-
Mean difference
- ms:
-
Milliseconds
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Kidoh, M., Utsunomiya, D., Funama, Y. et al. The effect of heart rate on coronary plaque measurements in 320-row coronary CT angiography. Int J Cardiovasc Imaging 34, 1977–1985 (2018). https://doi.org/10.1007/s10554-018-1415-0
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DOI: https://doi.org/10.1007/s10554-018-1415-0