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Mapping contrast agent uptake and retention in MRI studies of myocardial perfusion: case control study of dogs with Duchenne muscular dystrophy

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Abstract

Myocardial perfusion studies using dynamic contrast-enhanced cardiac magnetic resonance imaging (CMRI) could provide valuable, quantitative information regarding heart physiology in diseases such as Duchenne muscular dystrophy (DMD), that lead to diffuse myocardial damage. The goal of this effort was to develop an intuitive but physiologically meaningful method for quantifying myocardial perfusion by CMRI and to test its ability to detect global myocardial differences in a dog model of DMD. A discrete-time model was developed that parameterizes contrast agent kinetics in terms of an uptake coefficient that describes the forward flux of contrast agent into the tissue, and a retention coefficient that describes the rate of decay in tissue concentration due to contrast agent efflux. This model was tested in 5 dogs with DMD and 6 healthy controls which were imaged using a perfusion sequence on a 3T clinical scanner. CINE and delayed-enhancement CMRI acquisitions were also used to assess cardiac function and the presence of myocardial scar. Among functional parameters measured by CMRI, no significant differences were observed. No myocardial scar was observed. Increased perfusion in DMD was observed with an uptake coefficient of 6.76 ± 2.41 % compared to 2.98 ± 1.46 % in controls (p = 0.03). Additionally, the retention coefficient appeared lower at 82.2 ± 5.8 % in dogs with DMD compared to 90.5 ± 6.6 % in controls (p = 0.12). A discrete-time kinetic model of uptake and retention of contrast agent in perfusion CMRI shows potential for the study of DMD.

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Acknowledgments

We thank Baocheng Chu and Jennifer Totman for technical assistance with MRI; A. Joslyn, E. Zellmer, Jennifer Duncan, DVM, M. Spector, DVM and their team for their care of the dogs. We further thank S. Carbonneau, H. Crawford, B. Larson, K. Carbonneau, J. Vermeulen, and D. Gayle for administrative assistance and manuscript preparation. This work was supported by NIH U54-HD47175; NIH R01-AR056949; and by a Career Development Grant (to Z. Wang) from the Muscular Dystrophy Association (MDA 114979).

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Authors and Affiliations

  1. Department of Radiology, University of Washington, Seattle, WA, 98109, USA

    William S. Kerwin & Anna Naumova

  2. Program in Transplantation Biology, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA

    Rainer Storb & Zejing Wang

  3. Department of Medicine, University of Washington, Seattle, WA, 98195, USA

    Rainer Storb & Zejing Wang

  4. Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA

    Stephen J. Tapscott

  5. Department of Neurology, University of Washington, Seattle, WA, 98195, USA

    Stephen J. Tapscott

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  1. William S. Kerwin
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  2. Anna Naumova
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Correspondence to William S. Kerwin.

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Kerwin, W.S., Naumova, A., Storb, R. et al. Mapping contrast agent uptake and retention in MRI studies of myocardial perfusion: case control study of dogs with Duchenne muscular dystrophy. Int J Cardiovasc Imaging 29, 819–826 (2013). https://doi.org/10.1007/s10554-012-0137-y

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  • DOI: https://doi.org/10.1007/s10554-012-0137-y

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