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Monocyte counts and prostate cancer outcomes in white and black men: results from the SEARCH database

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Abstract

Purpose

Circulating inflammatory markers may predict prostate cancer (PC) outcomes. For example, a recent study showed that higher peripheral blood monocyte counts were associated with aggressive PC in Asian men undergoing radical prostatectomy (RP). Herein, we investigated whether peripheral monocyte count can predict long-term PC outcomes after RP in black and white men.

Methods

We retrospectively reviewed data on 2345 men undergoing RP from 2000 to 2017 at eight Veterans Affairs hospitals. Data on monocyte count within 6 and 12 months prior to surgery were collected. The study outcomes were biochemical recurrence (BCR), castration-resistant PC (CRPC), metastasis, all-cause mortality (ACM), and PC-specific morality (PCSM). Cox-proportional hazard models were used to assess the associations between pre-operative monocyte count and the above-mentioned outcomes accounting for confounders.

Results

Of 2345 RP patients, 972 (41%) were black and 1373 (59%) were white men. In multivariable analyses, we found no associations between monocyte count and BCR among all men (HR: 1.36, 95%CI 0.90–2.07) or when analyses were stratified by race (HR: 1.30, 95%CI 0.69–2.46, in black men; HR:1.33, 95%CI 0.76–02.33, in white men). Likewise, no overall or race-specific associations were found between monocyte count and CRPC, metastases, ACM, and PCSM, all p ≥ 0.15. Results were similar for monocyte count measured at 12 months prior to RP.

Conclusion

In black and white PC patients undergoing RP, peripheral monocyte count was not associated with long-term PC outcomes. Contrary to what was found in Asian populations, monocyte count was not associated with PC outcomes in this study.

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Funding

This study was supported by the National Institutes of Health; NIH 1R01CA231219-01 (WJA). Adriana Vidal was supported by a Research Scholar Grant, RSG-18–018-01—CPHPS, from the American Cancer Society.

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Authors and Affiliations

  1. Surgery Section, Durham VA Health Care System, Durham, NC, USA

    Azeb Yirga, Taofik Oyekunle, Lauren E. Howard, Amanda M. De Hoedt & Zachary Klaanssen

  2. Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA

    Taofik Oyekunle & Lauren E. Howard

  3. Department of Urology, Diller Family Comprehensive Cancer Center, UCSF Helen, San Francisco, CA, USA

    Matthew R. Cooperberg

  4. Urology Department, University of California San Diego Health System, San Diego, CA, USA

    Christopher J. Kane

  5. Urology Section, Department of Surgery, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA

    William J. Aronson

  6. Department of Urology, UCLA School of Medicine, Los Angeles, CA, USA

    William J. Aronson

  7. Section of Urology, Veterans Affairs Medical Center, Augusta, GA, USA

    Martha K. Terris

  8. Department of Surgery, Section of Urology, Medical College of Georgia, Augusta, GA, USA

    Martha K. Terris

  9. Department of Urology, Oregon Health and Science University Hospital, Portland, OR, USA

    Christopher L. Amling

  10. Institute for Translational Epidemiology and Tisch Cancer Institute, Icahn School of Medicine At Mount Sinai, New York, NY, USA

    Emanuela Taioli

  11. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA

    Jay H. Fowke

  12. Center for Integrated Research On Cancer and Lifestyle, Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, 8631 West 3rd Street Suite 430W, Los Angeles, CA, 90048, USA

    Stephen J. Freedland & Adriana C. Vidal

Authors
  1. Azeb Yirga
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  2. Taofik Oyekunle
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  3. Lauren E. Howard
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  4. Amanda M. De Hoedt
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  5. Matthew R. Cooperberg
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  6. Christopher J. Kane
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  7. William J. Aronson
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  8. Martha K. Terris
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  9. Christopher L. Amling
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  10. Emanuela Taioli
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  11. Jay H. Fowke
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  12. Zachary Klaanssen
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  13. Stephen J. Freedland
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  14. Adriana C. Vidal
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Corresponding author

Correspondence to Adriana C. Vidal.

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Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

The study protocol was approved by the institutional review boards of the Durham VA Health System and Cedars-Sinai Medical Center. Consent was obtained at time of entry to the study.

Research involving human participants and/or animals

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Yirga, A., Oyekunle, T., Howard, L.E. et al. Monocyte counts and prostate cancer outcomes in white and black men: results from the SEARCH database. Cancer Causes Control 32, 189–197 (2021). https://doi.org/10.1007/s10552-020-01373-2

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  • DOI: https://doi.org/10.1007/s10552-020-01373-2

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