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Influence of physical activity on active surveillance discontinuation in men with low-risk prostate cancer

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Abstract

Purpose

Epidemiologic data suggest that high levels of physical activity (PA) may reduce the risk of disease progression in men with prostate cancer (PCa), but it is unknown whether PA can delay the requirement for definitive treatment for those on active surveillance (AS). We investigated the influence of PA post-diagnosis on AS discontinuation in men with low-risk disease.

Methods

The effect of PA on the time to AS discontinuation was assessed in 421 patients, of whom 107 underwent additional PCa treatment over a median of 2.5 years.

Results

Using Cox regression models, we found that PA was not significantly associated with time to curative treatment initiation. Prostate-specific antigen (PSA) most proximal to AS initiation (HR, 1.11; 95% CI 1.03 to 1.21) and the number of positive cores (HR, 1.34; 95% CI 1.12 to 1.61) at diagnosis were associated with a significantly increased risk of discontinuing AS.

Conclusion

Our findings suggest that PA during AS for PCa does not significantly influence time to curative treatment.

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Acknowledgments

The authors would like to thank Mr. Alex Zisman and Dr. Isabelle Dore for their assistance in data acquisition and analysis.

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Authors and Affiliations

  1. Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada

    Efthymios Papadopoulos & Daniel Santa Mina

  2. Department of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON, Canada

    Efthymios Papadopoulos, Shabbir M. H. Alibhai & Daniel Santa Mina

  3. Faculty of Medicine, University of Toronto, Toronto, ON, Canada

    Shabbir M. H. Alibhai, George A. Tomlinson, Andrew G. Matthew, Antonio Finelli, John Trachtenberg & Daniel Santa Mina

  4. Department of Medicine, University Health Network, Toronto, ON, Canada

    Shabbir M. H. Alibhai, George A. Tomlinson & Andrew G. Matthew

  5. Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada

    Michael Nesbitt, Antonio Finelli & John Trachtenberg

  6. Institute for Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada

    George A. Tomlinson

Authors
  1. Efthymios Papadopoulos
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  2. Shabbir M. H. Alibhai
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  3. George A. Tomlinson
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  4. Andrew G. Matthew
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  5. Michael Nesbitt
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  6. Antonio Finelli
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  7. John Trachtenberg
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  8. Daniel Santa Mina
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Correspondence to Efthymios Papadopoulos.

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Papadopoulos, E., Alibhai, S.M.H., Tomlinson, G.A. et al. Influence of physical activity on active surveillance discontinuation in men with low-risk prostate cancer. Cancer Causes Control 30, 1009–1012 (2019). https://doi.org/10.1007/s10552-019-01211-0

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  • DOI: https://doi.org/10.1007/s10552-019-01211-0

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