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Recreational physical activity and survival in African-American women with ovarian cancer

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Abstract

Purpose

While recreational physical activity (RPA) has been associated with reduced mortality in breast, colorectal, and prostate cancers, evidence for epithelial ovarian cancer (EOC) is limited. Most EOC studies have been in predominantly white populations, although inactivity is more prevalent and survival is poorer among African-American (AA) women. We examined RPA before and after EOC diagnosis and associations with survival among AA women.

Methods

We analyzed data from 264 EOC survivors enrolled in a population-based, case–control study who completed surveys that included questions about pre- and post-diagnosis RPA. Data were collected on RPA frequency, intensity, and duration before diagnosis and approximately 1 year after the baseline interview. We calculated metabolic equivalent of task (MET)-hours/week for pre- and post-diagnosis RPA, and evaluated associations with risk of mortality using Cox proportional hazards models.

Results

RPA before diagnosis was not associated with mortality. Hazard ratios (HRs) for post-diagnosis RPA were < 1.0 but not statistically significant after adjustment for covariates; HRs were 0.94 (95% CI 0.58, 1.54) for > 0–9 MET-hours/week and 0.53 (95% CI 0.21, 1.35) for > 9 MET-hours/week.

Conclusions

Our results suggest that RPA may be inversely associated with mortality among AA women with ovarian cancer, although it is possible that the present study was underpowered to detect an association. There is a clear need for more studies of RPA after diagnosis in EOC survivors with attention to potential differences by race.

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Acknowledgments

We would like to acknowledge the AACES interviewers, Christine Bard, LaTonda Briggs, Whitney Franz (North Carolina), and Robin Gold (Detroit). We also acknowledge the individuals responsible for facilitating case ascertainment across the ten sites including Christie McCullum-Hill (Alabama); the Metropolitan Detroit Cancer Surveillance System staff (Detroit); Rana Bayakly, Vicki Bennett, Judy Andrews, and Debbie Chambers (Georgia); the Louisiana Tumor Registry; Lisa Paddock and Manisha Narang (New Jersey); Diana Slone, Yingli Wolinsky, Steven Waggoner, Anne Heugel, Nancy Fusco, Kelly Ferguson, Peter Rose, Deb Strater, Taryn Ferber, Donna White, Lynn Borzi, Eric Jenison, Nairmeen Haller, Debbie Thomas, Vivian von Gruenigen, Michele McCarroll, Joyce Neading, John Geisler, Stephanie Smiddy, David Cohn, Michele Vaughan, Luis Vaccarello, Elayna Freese, James Pavelka, Pam Plummer, William Nahhas, Ellen Cato, John Moroney, Mark Wysong, Tonia Combs, Marci Bowling, and Brandon Fletcher, (Ohio); Susan Bolick, Donna Acosta, and Catherine Flanagan (South Carolina); Martin Whiteside (Tennessee) and Georgina Armstrong and the Texas Registry, Cancer Epidemiology and Surveillance Branch, Department of State Health Services.

Funding

This study was supported by the National Cancer Institute (R01CA142081). Additional support was provided by the Metropolitan Detroit Cancer Surveillance System with funding from the National Cancer Institute, National Institute of Health, and the Department of Health and Human Services (Contract HHSN261201000028C), and the Epidemiology Research Core, supported in part by the National Cancer Institute (P30CA22453) to the Karmanos Cancer Institute, Wayne State University School of Medicine. The New Jersey State Cancer Registry, Cancer Epidemiology Services, New Jersey Department of Health, is funded by the Surveillance, Epidemiology and End Results (SEER) Program of the National Cancer Institute under Contract HHSN261201300021I, the National Program of Cancer Registries (NPCR), Centers for Disease Control and Prevention under Grant 5U58DP003931-02 as well as the State of New Jersey and the Rutgers Cancer Institute of New Jersey.

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Authors and Affiliations

  1. Department of Public Health Sciences, University of Virginia, PO Box 800765, Charlottesville, VA, 22903, USA

    Sarah E. Abbott, Fabian Camacho, Lauren C. Peres & Joellen M. Schildkraut

  2. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA

    Anthony J. Alberg

  3. Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA

    Elisa V. Bandera & Bo Qin

  4. Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, TX, USA

    Melissa Bondy

  5. Department of Oncology and the Karmanos Cancer Institute Population Studies and Disparities Research Program, Wayne State University, Detroit, MI, USA

    Michele L. Cote & Ann G. Schwartz

  6. Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    Ellen Funkhouser

  7. Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA

    Patricia G. Moorman

  8. Epidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA, USA

    Edward S. Peters

  9. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA

    Jill Barnholtz-Sloan

  10. Department of Medicine, University of Tennessee Medical Center-Knoxville, Knoxville, TN, USA

    Paul Terry

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  1. Sarah E. Abbott
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  2. Fabian Camacho
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  3. Lauren C. Peres
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  11. Bo Qin
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  15. Joellen M. Schildkraut
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Corresponding author

Correspondence to Joellen M. Schildkraut.

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This article does not contain any studies with animals performed by any of the authors.

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All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

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Abbott, S.E., Camacho, F., Peres, L.C. et al. Recreational physical activity and survival in African-American women with ovarian cancer. Cancer Causes Control 29, 77–86 (2018). https://doi.org/10.1007/s10552-017-0986-8

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  • DOI: https://doi.org/10.1007/s10552-017-0986-8

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